Buy DMXE Powder

Product Overview

DMXE (3,4-Methoxy-2-oxo-PCE, Dehydroxymethoxetamine, CAS 2666754-56-3) supplies researchers with a high-purity methoxetamine-class arylcyclohexylamine reference standard for dissociative pharmacology research, NMDA and sigma receptor binding studies, and forensic toxicology analytical method development within controlled laboratory environments. Researchers looking to buy DMXE for laboratory applications will find UltraRawz’s HPLC-verified material suitable for comparative arylcyclohexylamine SAR studies, LC-MS/MS method development for novel dissociative detection in biological matrices, NMDA receptor subunit affinity profiling, and in-vitro metabolic stability research using human liver microsome preparations. DMXE has emerged as one of the most pharmacologically distinctive dissociative research compounds in the post-MXE NPS landscape, combining arylcyclohexylamine scaffold features with a 3,4-dimethoxy substitution pattern that distinguishes it analytically and pharmacologically from monocyclic methoxyphenyl analogues. For research use only. Not for human or veterinary use. Not for clinical, diagnostic, or consumptive applications.

DMXE (3,4-Methoxy-2-oxo-PCE) represents a methoxetamine-class compound featuring a 3,4-dimethoxyphenyl ring — the same aromatic substitution pattern as the phenethylamine scaffold of 3,4-DMMA and related dimethoxyphenethylamines — combined with the arylcyclohexylamine (2-oxo-PCE) backbone of methoxetamine. This structural combination produces a compound with published sigma receptor binding data indicating significant sigma-1 receptor interaction alongside NMDA receptor antagonism, a dual receptor profile that distinguishes DMXE from ketamine-class compounds and makes it a valuable tool compound for researchers studying sigma receptor pharmacology in the context of dissociative drug mechanisms. DMXE has been detected in European forensic NPS monitoring programs since 2021, making it an emerging priority compound for forensic toxicology reference standard development. Buy DMXEresearch compound at UltraRawz for worldwide laboratory delivery.

DMXE is available at ultrarawz.com/shop in pellet format with multiple quantity options, HPLC-verified at ≥98% purity. Related dissociative research compounds including 2F-Ketamine, DCK, O-PCE, MXE, 3-MeO-PCP, and 3-MeO-PCE are available at ultrarawz.com — Dissociatives.

Chemical Identity & Classification

DMXE carries CAS number 2666754-56-3, molecular formula C₁₄H₁₉NO₃, and molecular weight 253.30 g/mol. Systematic IUPAC designation: 2-(3,4-dimethoxyphenyl)-2-(ethylamino)cyclohexan-1-one. Laboratory synonyms: 3,4-methoxy-2-oxo-PCE, dehydroxymethoxetamine, DMXE. Structural classification: arylcyclohexylamine with 3,4-dimethoxyphenyl substitution and N-ethyl secondary amine (N-ethyl distinguishes from N-methyl ketamine-class compounds). Key structural features: 3,4-dimethoxy phenyl ring (two OCH₃ groups, producing two ¹H NMR methoxy singlets and characteristic aromatic proton splitting pattern), cyclohexanone ring (ketone carbonyl at C-2), N-ethylamino group at alpha carbon. Protonated molecular ion [M+H]⁺: m/z 254. The two methoxy groups produce two ¹⁹F-absent methoxy NMR singlets at δ ~3.80–3.90 ppm (3H each) — diagnostic for 3,4-dimethoxy substitution. PubChem CID: Not yet assigned at time of writing — verify current CID at pubchem.ncbi.nlm.nih.gov.

Chemical & Physical Characteristics

DMXE manifests as white to off-white crystalline solid or powder (HCl salt). DMSO solubility: ≥10 mg/mL. Methanol and ethanol: soluble. Aqueous solubility: moderate (HCl salt). logP: ~2.1 (calculated free base — the 3,4-dimethoxy phenyl ring increases polarity relative to unsubstituted phenyl DCK while maintaining adequate lipophilicity for CNS receptor assay work). UV absorption: ~280–290 nm (3,4-dimethoxyphenyl chromophore — bathochromic shift relative to unsubstituted phenyl arylcyclohexylamines at ~254 nm, useful for HPLC-UV wavelength optimization). The N-ethyl group (rather than N-methyl as in ketamine and DCK) produces characteristic ethyl CH₂ and CH₃ NMR signals distinguishing DMXE from N-methyl arylcyclohexylamine analogues in ¹H NMR screening. Hygroscopicity: moderate (HCl salt).

Purity & Analytical Verification

Production lots certify ≥98% purity by gradient HPLC (C18 reverse-phase, acetonitrile/0.1% formic acid gradient, UV 280 nm, area normalization). Identity confirmed by: ¹H NMR (CDCl₃) — two methoxy singlets at δ ~3.80–3.90 ppm (3H each, 3- and 4-position OCH₃), 3,4-disubstituted aromatic proton ABX system at δ 6.7–7.0 ppm (3H), N-ethyl CH₂ quartet at δ ~2.6–2.8 ppm (2H) and CH₃ triplet at δ ~1.0–1.1 ppm (3H) — combined NMR pattern provides unambiguous structural confirmation distinguishing DMXE from MXE (3-methoxy only, N-ethyl), O-PCE (2-oxo, N-ethyl, no methoxy), and other arylcyclohexylamines. GC-MS: molecular ion m/z 253; base peak m/z 72 (N-ethylaminopropyl fragment). LC-MS/MS: [M+H]⁺ m/z 254; fragments m/z 236 (loss of H₂O), m/z 165 (3,4-dimethoxyphenyl + CO). Karl Fischer water content: <1.0% w/w. COA at support@ultrarawz.com.

Quality Control & Batch Integrity

Each production batch undergoes multi-stage quality verification: HPLC purity, ¹H NMR identity confirmation (dual methoxy singlet integration verification — 3H:3H ratio confirming 3,4-dimethoxy vs 3-methoxy only substitution; N-ethyl vs N-methyl pattern confirmation), GC-MS molecular ion verification, Karl Fischer water content, and visual appearance. Dual methoxy NMR integration is a specific release criterion ensuring correct dimethoxy versus monomethoxy regiochemistry. Retained reference samples support stability monitoring and reanalysis capability.

Safety, Handling & Laboratory Precautions

Handle exclusively within a properly ventilated fume hood. Required PPE: nitrile gloves (double-glove), lab coat, safety glasses, N95 respirator when handling powder. NMDA and sigma receptor active compound — prevent dermal contact; verify glove integrity. Anti-static weighing vessels for sub-10mg measurements. Spill: absorb with inert material, sealed container, institutional chemical waste disposal. Emergency: skin contact — wash with soap and water; eye contact — flush 15 minutes, seek medical attention. Compound usage log maintained per lot.

Packaging, Labeling & Storage

DMXE is supplied in sealed amber glass vials with inert closures and desiccant packs, in discreet external packaging. Labels specify compound name, CAS 2666754-56-3, lot number, purity, and research use notice. Recommended storage: -20°C long-term; ≤25°C short-term (active use, max 2 weeks, desiccated, sealed). Amber glass protects against UV photodegradation of the dimethoxyphenyl chromophore. Do not store in polystyrene. Under recommended conditions, compound integrity maintained for lot expiry period on COA.

Intended Research Use & Market Positioning

DMXE is positioned for: NMDA receptor pharmacology programs examining 3,4-dimethoxyphenyl substitution effects on arylcyclohexylamine receptor binding profiles versus mono-methoxy (MXE) and non-methoxy (DCK, O-PCE) analogues; sigma-1 receptor binding studies examining DMXE’s dual NMDA/sigma pharmacology in comparative assay panels; forensic toxicology laboratories developing LC-MS/MS identification methods for DMXE in biological matrices as part of expanding dissociative NPS surveillance programs; in-vitro metabolic stability research examining CYP-mediated O-demethylation and N-deethylation pathways using HLM preparations; and academic dissociative pharmacology SAR programs building comprehensive methoxyphenyl arylcyclohexylamine structure-activity datasets. Browse related compounds at ultrarawz.com — Dissociatives.

Ordering, Availability & Fulfillment

DMXE is available in pellet format across multiple quantity options — see variants above for current pricing. Payment methods: Bitcoin (BTC), bank transfer, Interac E-Transfer (Canada), Apple Pay (US), Zelle (US), Chime (US), Revolut (Europe), gift cards — full details at ultrarawz.com/payment. Orders processed same day, discreet secure packaging. Worldwide shipping from US and Netherlands warehouses. Delivery: 2–5 business days (US/EU); 5–10 days international. Institutional pricing and COA requests: support@ultrarawz.com or WhatsApp +1 (567) 457-7456. Track at ultrarawz.com/track-order.

Legal & Regulatory Disclaimer

DMXE (CAS 2666754-56-3) is supplied strictly for laboratory research purposes only. Not for human or veterinary use. Not for clinical, diagnostic, or consumptive applications. Regulatory status varies by jurisdiction. Purchasers are solely responsible for verifying compliance with all applicable local, national, and international regulations prior to ordering. UltraRawz supplies exclusively to qualified research professionals for legitimate laboratory research purposes.

Frequently Asked Questions

Q: How does DMXE differ analytically from MXE (methoxetamine)?
A: Three key differences: (1) DMXE has 3,4-dimethoxy phenyl ring (two OCH₃ groups), MXE has 3-methoxy only (one OCH₃); (2) MW — DMXE 253.30 vs MXE 247.33 g/mol (+5.97 Da dimethoxy vs methoxy + 2-oxo shift); (3) ¹H NMR — DMXE shows two methoxy singlets (~3H:3H ratio), MXE shows one methoxy singlet (3H). HPLC retention time also differs reflecting different logP values.

Q: What makes DMXE pharmacologically distinctive versus ketamine?
A: Published binding data indicates DMXE has significant sigma-1 receptor interaction alongside NMDA antagonism — a dual receptor profile contrasting with ketamine’s primary NMDA selectivity. The 3,4-dimethoxy phenyl substitution and N-ethyl group are proposed structural contributors to this expanded receptor profile, making DMXE a useful comparative tool compound in sigma/NMDA interaction research.

Q: What purity does UltraRawz DMXE achieve?
A: ≥98% by HPLC area normalization. COA with HPLC chromatogram and NMR data available on request.

Q: What LC-MS/MS fragments identify DMXE?
A: [M+H]⁺ m/z 254; key fragments m/z 236 (loss of H₂O, 18 Da), m/z 165 (3,4-dimethoxyphenyl + CO fragment). These transitions distinguish DMXE from other arylcyclohexylamines in multi-compound MRM methods.

Q: What related dissociatives does UltraRawz carry?
A: 2F-Ketamine, DCK, O-PCE, MXE, 3-MeO-PCP, 3-MeO-PCE, Methoxpropamine. Browse at ultrarawz.com — Dissociatives.

Q: Do you ship internationally?
A: Yes, worldwide from US and Netherlands. Verify local regulations before ordering. See shipping & delivery.