Buy 2F-Ketamine Crystal Chunks

Product Overview

2F-Ketamine (2-Fluorodeschloroketamine, 2-FDCK, CAS 111982-49-1) supplies researchers with a high-purity fluorinated arylcyclohexylamine reference standard for dissociative pharmacology research, NMDA receptor antagonist binding studies, and forensic toxicology analytical method development within controlled laboratory environments. Researchers looking to buy 2F-ketamine for laboratory applications will find UltraRawz’s HPLC-verified material suitable for NMDA receptor subunit binding affinity profiling, comparative arylcyclohexylamine SAR studies, LC-MS/MS analytical method development for fluorinated dissociative detection in biological matrices, and in-vitro metabolite identification studies using human liver microsome preparations. 2-FDCK has become one of the most frequently detected novel dissociative compounds in European and North American forensic submissions over the past five years, generating significant demand for authenticated reference standards from toxicology laboratories developing validated screening methodologies. For research use only. Not for human or veterinary use. Not for clinical, diagnostic, or consumptive applications.

2F-Ketamine (2-FDCK) is structurally related to ketamine — sharing the arylcyclohexylamine scaffold and 2-position ortho-substitution on the phenyl ring — but substitutes a fluorine atom for ketamine’s chlorine at the 2-position. This halogen exchange (Cl → F) reduces molecular weight by approximately 18 Da (ketamine MW 237.73 vs 2-FDCK MW 219.26 g/mol) and profoundly alters several analytical characteristics: the absence of the ⁷⁹Cl/⁸¹Cl isotope doublet in 2-FDCK MS spectra (which is present in ketamine), the appearance of a ¹⁹F NMR signal for definitive identity confirmation, and measurably different HPLC retention time reflecting altered logP. These analytical differences make ketamine/2-FDCK discrimination a routine challenge in forensic NPS screening programs that rely on authentic reference standards. 2F-ketamine for sale at UltraRawz ships worldwide with discreet packaging and same-day order processing from US and Netherlands warehouses.

Each batch of 2F-ketamine research compound at ultrarawz.com/shop is HPLC-verified at ≥98% purity with batch-specific COA documentation. Related dissociative research compounds available at UltraRawz include DCK (deschloroketamine), O-PCE (2-oxo-PCE), DMXE, MXE, and 3-MeO-PCE — browse the complete dissociative research catalog at ultrarawz.com — Dissociatives.

Chemical Identity & Classification

2F-Ketamine carries CAS number 111982-49-1, molecular formula C₁₃H₁₆FNO, and molecular weight 219.26 g/mol. Systematic IUPAC designation: 2-(2-fluorophenyl)-2-(methylamino)cyclohexan-1-one. Laboratory synonyms: 2-fluorodeschloroketamine, 2-FDCK, fluoroketamine, 2-FK. Structural classification: arylcyclohexylamine dissociative — cyclohexanone scaffold with N-methyl secondary amine and 2-fluorophenyl group at the alpha carbon (C-2). The 2-fluorophenyl substitution (ortho-fluorine) is the defining structural feature, producing ¹⁹F NMR diagnostic signal at approximately δ -118 to -120 ppm (CDCl₃) for unambiguous identity confirmation. Compound exists as a racemic mixture of R and S enantiomers at the C-2 chiral center. Protonated molecular ion [M+H]⁺: m/z 220. PubChem CID: 155903. No chlorine isotope doublet in MS spectra — distinguishing feature from ketamine (m/z 238/240 doublet).

Chemical & Physical Characteristics

2F-Ketamine manifests as white to off-white crystalline powder (hydrochloride salt or free base depending on format). DMSO solubility: ≥10 mg/mL. Methanol and ethanol: freely soluble. Aqueous solubility: moderate (HCl salt form). logP: ~2.2 (calculated free base — similar to ketamine logP ~2.2, fluorine partially compensating for absent chlorine in lipophilicity contribution). UV absorption: ~270 nm (arylcyclohexylamine chromophore with fluorophenyl contribution). The fluorine atom at the 2-position contributes to ¹⁹F NMR characterization — a particularly valuable analytical tool for identity confirmation given that no other endogenous or common matrix component produces signals in the ¹⁹F chemical shift range. Hygroscopicity: moderate (HCl salt form). Melting point: ~225–228°C (HCl salt).

Purity & Analytical Verification

Production lots certify ≥98% purity by gradient HPLC (C18 reverse-phase, acetonitrile/0.1% formic acid gradient, UV 270 nm, area normalization). Identity confirmed by: ¹H NMR (CDCl₃) — 2-fluorophenyl ortho-substitution aromatic pattern at δ 6.9–7.3 ppm with characteristic F-H coupling constants (³J(HF) ~8–9 Hz) distinguishing from 2-chlorophenyl ketamine pattern. ¹⁹F NMR: signal at δ ~-118 to -120 ppm confirming 2-fluorophenyl substitution — unambiguous identity marker absent in all non-fluorinated arylcyclohexylamine analogues. GC-MS: molecular ion at m/z 219 (no chlorine isotope doublet — immediate visual distinction from ketamine m/z 237/239). LC-MS/MS: [M+H]⁺ m/z 220; characteristic fragments m/z 202 (loss of H₂O, 18 Da) and m/z 163 (loss of methylamine + H₂O). Karl Fischer water content: <1.0% w/w. COA available at support@ultrarawz.com.

Quality Control & Batch Integrity

Each production batch undergoes multi-stage quality verification: HPLC purity assessment, ¹H and ¹⁹F NMR identity confirmation (fluorophenyl coupling constant and ¹⁹F chemical shift verification), GC-MS molecular ion confirmation (absence of chlorine isotope doublet verified), Karl Fischer water content, and visual appearance inspection. The ¹⁹F NMR chemical shift verification is a batch-specific release criterion providing identity confidence independent of MS data. Batch-specific lot numbers enable full traceability. Retained reference samples support stability monitoring and reanalysis capability.

Safety, Handling & Laboratory Precautions

Handle exclusively within a properly ventilated fume hood or biosafety cabinet. Required PPE: nitrile gloves (double-glove), lab coat, safety glasses, N95 respirator when handling powder. NMDA receptor antagonist — prevent dermal absorption; verify glove integrity. Anti-static weighing vessels recommended for sub-10mg measurements. Spill: absorb with inert material, collect in sealed container, dispose per institutional chemical waste procedures. Emergency: skin contact — wash with soap and water; eye contact — flush 15 minutes, seek medical attention. Do not eat, drink, or smoke when handling. Maintain compound usage log for traceability. Note: as a racemic mixture, enantiomeric separation is possible on chiral HPLC columns for researchers requiring enantioselective pharmacological data.

Packaging, Labeling & Storage

2F-Ketamine research compound is supplied in sealed amber glass vials with inert closures and desiccant packs, in discreet external packaging. Labels specify compound name, CAS 111982-49-1, lot number, purity, and research use notice. Recommended storage: -20°C long-term; ≤25°C short-term (active use, max 2 weeks, desiccated, sealed). Amber glass protects against UV photodegradation of the fluorophenyl chromophore. Do not store in polystyrene containers. Under recommended conditions, compound integrity maintained for the lot expiry period stated on the COA.

Intended Research Use & Market Positioning

2F-Ketamine research compound is positioned for: forensic toxicology laboratories developing LC-MS/MS identification methods for 2-FDCK detection and discrimination from ketamine in blood, urine, hair, and biological matrices; NMDA receptor subunit binding affinity studies comparing fluorine versus chlorine 2-position substitution effects on arylcyclohexylamine receptor interactions; in-vitro metabolite identification programs characterizing 2-FDCK Phase I biotransformation pathways using HLM and recombinant CYP3A4/2B6 enzyme systems; comparative arylcyclohexylamine SAR programs examining the pharmacological and physicochemical consequences of halogen exchange at the 2-phenyl position; and academic dissociative pharmacology programs studying NMDA receptor antagonism mechanisms using structurally defined reference tool compounds. Browse related dissociative research compounds at ultrarawz.com — Dissociatives.

Ordering, Availability & Fulfillment

2F-Ketamine research compound is available in multiple formats and quantities — see product variants above for current pricing. Payment methods: Bitcoin (BTC), bank transfer, Interac E-Transfer (Canada), Apple Pay (US), Zelle (US), Chime (US), Revolut (Europe), gift cards — full details at ultrarawz.com/payment. Orders processed same day with discreet, secure packaging. Worldwide shipping from US and Netherlands warehouses via DHL Express and FedEx. Delivery: 2–5 business days (US/EU); 5–10 business days international. Institutional pricing and COA requests: support@ultrarawz.comor WhatsApp +1 (567) 457-7456. Track at ultrarawz.com/track-order.

Legal & Regulatory Disclaimer

2F-Ketamine (2-FDCK, CAS 111982-49-1) is supplied strictly for laboratory research purposes only. Not for human or veterinary use. Not for clinical, diagnostic, or consumptive applications. Regulatory status varies by jurisdiction — 2-FDCK is controlled in several countries and US states. Note that ketamine itself is a Schedule III controlled substance in the US; the scheduling status of structurally related fluorinated analogues varies and purchasers must independently verify applicable regulations. Purchasers are solely responsible for compliance with all applicable local, national, and international regulations prior to ordering. UltraRawz supplies this compound exclusively to qualified research professionals for legitimate laboratory research purposes.

Frequently Asked Questions

Q: What is the key analytical difference between 2F-ketamine and ketamine?
A: Three main differences: (1) MW — 2-FDCK 219.26 vs ketamine 237.73 g/mol (–18 Da, F replaces Cl); (2) MS isotope pattern — 2-FDCK shows single molecular ion at m/z 219 (no isotope doublet), ketamine shows ⁷⁹Cl/⁸¹Cl doublet at m/z 237/239; (3) ¹⁹F NMR — 2-FDCK produces signal at δ ~-118 ppm absent in ketamine spectra.

Q: Can the ¹⁹F NMR signal alone confirm 2F-ketamine identity?
A: Yes — the ¹⁹F NMR signal at δ ~-118 to -120 ppm is an unambiguous marker for 2-fluorophenyl substitution that no non-fluorinated compound can produce. Combined with ¹H NMR arylcyclohexylamine scaffold signals, it provides complete structural confirmation independent of mass spectrometric data.

Q: What purity does UltraRawz 2F-ketamine achieve?
A: ≥98% by HPLC area normalization. Batch-specific COA with HPLC chromatogram, NMR, and ¹⁹F NMR data available on request.

Q: What LC-MS/MS transitions identify 2F-ketamine?
A: [M+H]⁺ m/z 220; fragments m/z 202 (loss of H₂O), m/z 163 (loss of methylamine + H₂O). These transitions are documented in published forensic NPS screening method papers.

Q: Is 2F-ketamine a racemic mixture?
A: Yes — supplied as racemate (R and S enantiomers). Enantiomeric separation is possible using chiral HPLC columns for researchers requiring enantioselective pharmacological or metabolic data.

Q: What related dissociatives does UltraRawz carry?
A: Full dissociative research panel including DCK (deschloroketamine), O-PCE, DMXE, MXE, and 3-MeO-PCE. Browse at ultrarawz.com — Dissociatives.

Q: Do you ship internationally?
A: Yes, worldwide from US and Netherlands warehouses. Purchasers must verify local regulations before ordering. See shipping & delivery.