Buy O-DSMT Pellets 50mg

Product Overview

O-DSMT (O-Desmethyltramadol, CAS 73986-53-5) supplies researchers with a high-purity tramadol active metabolite reference standard for opioid receptor pharmacology research, tramadol metabolite identification studies, and forensic toxicology analytical method development within controlled laboratory environments. Researchers looking to buy O-DSMT for laboratory applications will find UltraRawz’s HPLC-verified material suitable for μ-opioid receptor binding affinity studies, tramadol Phase I metabolic pathway characterization using human liver microsome preparations, LC-MS/MS method development for opioid metabolite detection in biological matrices, and serotonin/norepinephrine reuptake inhibition comparative profiling. O-DSMT is the primary active metabolite responsible for the μ-opioid receptor-mediated pharmacological activity of tramadol in published pharmacokinetic and receptor binding literature, making it an indispensable reference compound for research programs investigating tramadol’s mechanism of action, metabolite pharmacology, and forensic case interpretation. For research use only. Not for human or veterinary use. Not for clinical, diagnostic, or consumptive applications.

O-DSMT (O-desmethyltramadol) is produced in vivo through CYP2D6-mediated O-demethylation of tramadol — the primary Phase I biotransformation responsible for converting the relatively weak μ-opioid agonist tramadol into the potent metabolite O-DSMT, which exhibits approximately 200-fold higher μ-opioid receptor affinity than the parent compound in published radioligand displacement studies. This dramatic potency difference between tramadol and O-DSMT has significant implications for forensic toxicological case interpretation, particularly in cases involving CYP2D6 ultrarapid metabolizers, and makes O-DSMT a critical reference standard for forensic laboratories performing tramadol case work. Additionally, O-DSMT has been encountered as a standalone NPS compound in forensic submissions independent of tramadol, further expanding its relevance as an analytical reference standard. O-DSMT for sale at UltraRawz ships worldwide with discreet packaging from our US and Netherlands warehouses.

O-DSMT is available at ultrarawz.com/shop in powder and pellet formats across multiple quantities, HPLC-verified at ≥98% purity with batch-specific COA documentation. Related opioid and opioid receptor research compounds available at UltraRawz include tramadol, U-47700, U-48800, AH-7921, and AP-237 — browse at ultrarawz.com — Opioids.

Chemical Identity & Classification

O-DSMT carries CAS number 73986-53-5, molecular formula C₁₅H₂₃NO₂, and molecular weight 253.34 g/mol. Systematic IUPAC designation: (1R,2R)-2-[(dimethylamino)methyl]-1-(3-hydroxyphenyl)cyclohexan-1-ol. Laboratory synonyms: O-desmethyltramadol, (+)-O-desmethyltramadol (active enantiomer), M1 metabolite of tramadol. Structural classification: phenylcyclohexanol opioid — 3-hydroxyphenyl group (free phenol) at C-1, dimethylaminomethyl side chain at C-2, tertiary alcohol at C-1. The free 3-hydroxyphenyl group (versus tramadol’s 3-methoxyphenyl) is the structural distinction from tramadol produced by CYP2D6 O-demethylation — this phenol group is pharmacologically critical for high-affinity μ-opioid receptor binding and also provides a diagnostic NMR signal (phenolic OH broad singlet) and distinct HPLC behavior relative to the methoxy-bearing parent. Protonated molecular ion [M+H]⁺: m/z 254. PubChem CID: 5464813.

Chemical & Physical Characteristics

O-DSMT manifests as white to off-white crystalline powder (HCl salt). DMSO solubility: ≥10 mg/mL. Methanol and ethanol: soluble. Aqueous solubility: good (HCl salt, tertiary amine and phenol moieties contribute to water compatibility). logP: ~1.4 (calculated free base — lower than tramadol ~2.0, reflecting phenol vs methoxy substitution). UV absorption: ~270–275 nm (3-hydroxyphenyl chromophore — slightly red-shifted vs tramadol at ~270 nm due to phenol vs methoxy UV perturbation, useful for HPLC-UV wavelength optimization). The free phenol in O-DSMT is susceptible to oxidative degradation — avoid prolonged exposure to atmospheric oxygen, strong oxidizing agents, or alkaline pH conditions which accelerate phenol autoxidation. Hygroscopicity: moderate (HCl salt). Supplied as racemate unless otherwise specified — the (+)-enantiomer (1R,2R) is the primary pharmacologically active form in published receptor binding literature.

Purity & Analytical Verification

Production lots certify ≥98% purity by gradient HPLC (C18 reverse-phase, acetonitrile/0.1% formic acid gradient, UV 270 nm, area normalization). Identity confirmed by: ¹H NMR (CDCl₃ or D₂O HCl salt) — 3-hydroxyphenyl aromatic protons at δ 6.7–7.2 ppm (4H, monosubstituted + para-OH pattern, distinguished from tramadol 3-methoxyphenyl 4H pattern with methoxy singlet at δ ~3.8 ppm); absence of methoxy singlet confirms O-demethylation product identity versus parent tramadol. LC-MS/MS: [M+H]⁺ m/z 254; MRM quantifier 254→58 (dimethylaminomethyl fragment, loss of 196 Da); qualifier 254→42 (trimethylamine fragment). GC-MS: requires TMS or acetyl derivatization of phenol for optimized GC performance; derivatized molecular ion diagnostic. Karl Fischer water content: <1.0% w/w. COA at support@ultrarawz.com.

Quality Control & Batch Integrity

Each production batch undergoes multi-stage quality verification: HPLC purity, ¹H NMR identity confirmation (3-hydroxyphenyl aromatic pattern verification and absence of methoxy singlet — confirming O-desmethyl product vs unreacted tramadol), LC-MS/MS molecular ion and key fragment confirmation, Karl Fischer water content, and visual appearance. The absence of methoxy NMR signal is a specific release criterion confirming complete O-demethylation identity. Phenolic compound oxidative stability monitored in stability studies. Retained reference samples per batch support reanalysis. Lot numbers enable full traceability for published research citation requirements.

Safety, Handling & Laboratory Precautions

Handle exclusively within a properly ventilated fume hood. Required PPE: nitrile gloves (double-glove), lab coat, safety glasses, N95 respirator when handling powder. μ-Opioid receptor agonist — highest priority dermal absorption prevention among compounds in this catalog; double-glove protocol mandatory, verify integrity before and during all handling. Anti-static weighing vessels for accurate sub-mg measurements. Minimize oxygen exposure in solution — phenol functional group susceptible to autoxidation; prepare aqueous stock solutions fresh and use same session where possible. Spill: absorb with inert material, sealed container, institutional chemical waste disposal following opioid handling protocols applicable to your institution. Emergency: if skin contact, wash immediately and thoroughly with soap and water; if eye contact, flush 15 minutes, seek medical attention immediately; if significant inhalation exposure, seek medical attention.

Packaging, Labeling & Storage

O-DSMT is supplied in sealed amber glass vials with inert closures and desiccant packs, in discreet external packaging. Labels specify compound name, CAS 73986-53-5, lot number, purity, and research use notice. Recommended storage: -20°C long-term; ≤4°C (refrigerator) short-term active use — phenolic compounds benefit from refrigerator rather than room temperature short-term storage to minimize oxidative degradation. Amber glass protects phenol from UV-catalyzed oxidation. Minimize headspace oxygen after opening — N₂ purge recommended for batches used over extended periods. Do not store in polystyrene. Under recommended conditions, integrity maintained for lot expiry period on COA.

Intended Research Use & Market Positioning

O-DSMT research compound is positioned for: forensic toxicology laboratories developing and validating LC-MS/MS methods for simultaneous tramadol and O-DSMT quantitation in blood, urine, and hair matrices for clinical and postmortem case work; μ-opioid receptor binding studies examining the pharmacological basis for O-DSMT’s high-affinity receptor interaction versus tramadol’s low-affinity profile; CYP2D6 phenotyping research using tramadol-to-O-DSMT metabolic ratio as a CYP2D6 activity marker in metabolic phenotyping programs; forensic NPS case work where O-DSMT has been detected as a standalone compound requiring reference standard authentication; and academic opioid pharmacology programs studying phenylcyclohexanol opioid structure-activity relationships. Browse related opioid reference compounds at ultrarawz.com — Opioids.

Ordering, Availability & Fulfillment

O-DSMT is available in powder and pellet formats across multiple quantities — see variants above for current pricing. Payment methods: Bitcoin (BTC), bank transfer, Interac E-Transfer (Canada), Apple Pay (US), Zelle (US), Chime (US), Revolut (Europe), gift cards — full details at ultrarawz.com/payment. Orders processed same day, discreet secure packaging. Worldwide shipping from US and Netherlands warehouses. Delivery: 2–5 business days (US/EU); 5–10 days international. Institutional pricing and COA requests: support@ultrarawz.com or WhatsApp +1 (567) 457-7456. Track at ultrarawz.com/track-order.

Legal & Regulatory Disclaimer

O-DSMT (CAS 73986-53-5) is supplied strictly for laboratory research purposes only. Not for human or veterinary use. Not for clinical, diagnostic, or consumptive applications. O-DSMT regulatory status varies by jurisdiction — in the United States, O-DSMT is not separately scheduled federally under the CSA but may be subject to analogue act provisions depending on application; tramadol itself is Schedule IV. Regulatory status varies internationally. Purchasers are solely responsible for verifying compliance with all applicable local, national, and international regulations prior to ordering. UltraRawz supplies exclusively to qualified research professionals for legitimate laboratory research purposes.

Frequently Asked Questions

Q: What is the pharmacological relationship between O-DSMT and tramadol?
A: O-DSMT is the primary active metabolite of tramadol produced via CYP2D6-mediated O-demethylation. Published radioligand binding studies show O-DSMT has approximately 200-fold higher μ-opioid receptor affinity than tramadol — meaning the analgesic activity of tramadol is largely mediated through O-DSMT formation. This makes O-DSMT an essential paired reference standard for any tramadol pharmacology or forensic case work.

Q: How does ¹H NMR distinguish O-DSMT from tramadol?
A: Tramadol has a 3-methoxyphenyl ring — its ¹H NMR shows a methoxy singlet at δ ~3.8 ppm (3H, OCH₃). O-DSMT has a 3-hydroxyphenyl ring — no methoxy singlet present, replaced by a broad phenolic OH signal. This single NMR difference is diagnostic and unambiguous for confirming O-demethylation identity.

Q: What purity does UltraRawz O-DSMT achieve?
A: ≥98% by HPLC area normalization. COA with HPLC chromatogram and NMR data available on request.

Q: Why does O-DSMT require refrigerator short-term storage rather than room temperature?
A: The free phenol group in O-DSMT is susceptible to autoxidation at room temperature over days to weeks. Refrigerator storage (≤4°C) significantly slows oxidative degradation rates compared to the ≤25°C standard short-term recommendation used for non-phenolic compounds.

Q: Is O-DSMT supplied as the racemate or single enantiomer?
A: Supplied as racemate unless otherwise specified. The (+)-(1R,2R) enantiomer is the primary pharmacologically active form — chiral HPLC separation is possible for stereoselective pharmacological research requiring individual enantiomers.

Q: What related opioid compounds does UltraRawz carry?
A: Tramadol, U-47700, U-48800, AH-7921, AP-237 and others. Browse at ultrarawz.com — Opioids.

Q: Do you ship internationally?
A: Yes, worldwide from US and Netherlands. Purchasers must verify local regulations before ordering. See shipping & delivery.