Buy Etizolam Pure

Product Overview

Etizolam (CAS 40054-69-1) supplies researchers with a high-purity thienodiazepine reference standard for forensic toxicology analytical method development, GABA-A receptor binding studies, and comparative benzodiazepine pharmacology research within controlled laboratory environments. Researchers looking to buy etizolam for laboratory applications will find UltraRawz’s HPLC-verified material suitable for LC-MS/MS MRM method development, in-vitro plasma stability assays, human liver microsome (HLM) metabolite identification studies, and multi-compound forensic screening panel validation. Etizolam is structurally classified as a thienodiazepine rather than a classical benzodiazepine — its thiophene ring replaces the benzene ring of the standard benzodiazepine scaffold — making it an important comparative reference compound in SAR studies examining how ring system modification affects GABA-A receptor subtype selectivity and pharmacokinetic profiles. For research use only. Not for human or veterinary use. Not for clinical, diagnostic, or consumptive applications.

In published CNS pharmacology research, etizolam is characterized as a full agonist at GABA-A receptor benzodiazepine binding sites, with documented anxiolytic, sedative, and muscle-relaxant properties in in-vitro and animal model research contexts. Its intermediate-acting pharmacokinetic profile (in-vitro half-life approximately 6–8 hours) and thienodiazepine scaffold make it a distinctive reference compound for researchers studying the pharmacological divergence between thieno- and classical benzodiazepine compound classes. Etizolam appears in forensic toxicology case literature and NPS monitoring reports across multiple jurisdictions, driving sustained demand for authenticated analytical reference standards from research laboratories developing validated screening methodologies. Etizolam for sale at UltraRawz ships worldwide with discreet packaging from US and Netherlands warehouses.

Etizolam is listed in the Cayman Chemical analytical reference standards catalog (CAS 40054-69-1), referenced in published forensic method validation literature, and regularly included in multi-compound benzodiazepine screening panels alongside structurally related compounds including bromazolam, clonazolam, flualprazolam, and diclazepam — all of which are available at ultrarawz.com/shop — Benzodiazepines category. Each batch of etizolam research chemical from UltraRawz is batch-certified at ≥98% purity with full COA documentation available on request.

Chemical Identity & Classification

Etizolam carries CAS number 40054-69-1, molecular formula C₁₇H₁₅ClN₄S, and molecular weight 342.84 g/mol. Systematic IUPAC designation: 4-(2-chlorophenyl)-2-ethyl-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine. Laboratory synonyms include Y-7131, AHR-3219, and Etilaam (pharmaceutical preparation in Japan and India, where it has approved medical uses). Structurally classified as a thienotriazolodiazepine — featuring a thiophene ring fused with a triazolo ring and diazepine scaffold — etizolam is distinguished from classical benzodiazepines by the thieno rather than benzo ring system. This structural feature produces distinct HPLC retention behavior and unique NMR thiophene proton signals enabling definitive structural confirmation. PubChem CID: 2764781. ChemSpider ID: 2046783.

Chemical & Physical Characteristics

Etizolam manifests as white to off-white crystalline powder with a melting point of approximately 147–148°C. DMSO solubility: ≥10 mg/mL. Methanol and ethanol: soluble. Aqueous solubility: sparingly soluble at physiological pH (logP 3.5 calculated, conferring high lipophilicity). UV absorption: characteristic absorption at approximately 230–240 nm arising from the thienotriazolodiazepine chromophore. The compound is not supplied as a salt form in standard research grade material — the free base is the predominant form. Hygroscopicity: moderate — store with desiccant. Thermal stability: stable under recommended cold storage conditions. Photosensitivity: protect from UV light; amber glass storage vials recommended. For HPLC stock solution preparation, 10 mM DMSO stock solutions are standard; final DMSO concentration in assay media should not exceed 0.1%.

Purity & Analytical Verification

Production lots certify ≥98% purity by gradient HPLC (C18 reverse-phase column, acetonitrile/ammonium formate buffer gradient, UV detection at 230 nm, area normalization method). Identity confirmed by ¹H NMR (CDCl₃) showing characteristic thiophene ring signals at δ 7.0–7.2 ppm that distinguish etizolam from classical benzodiazepines with comparable molecular weights — a key spectroscopic differentiator in multi-compound NMR library matching. LC-MS/MS identity: protonated molecular ion [M+H]⁺ at m/z 343; MRM quantifier transition 343→314 (loss of 29 Da, ethyl group fragment); qualifier transition 343→296. Karl Fischer water content: <1.0% w/w. Batch-specific COA includes HPLC chromatogram, NMR spectral data, and MS fragmentation confirmation. COA available on request via support@ultrarawz.com.

Quality Control & Batch Integrity

Each production batch undergoes multi-stage quality verification: HPLC purity assessment (area normalization), ¹H NMR identity confirmation (thiophene ring signal verification), LC-MS/MS molecular ion and fragment confirmation, Karl Fischer water content determination, and visual appearance inspection. Batch-specific lot numbers enable full traceability. Retained reference samples per batch support stability monitoring. Thermal stability data confirms compound integrity under -20°C desiccated storage. Photostability testing confirms UV degradation susceptibility, supporting amber glass container specification for all storage and handling operations.

Safety, Handling & Laboratory Precautions

Handle exclusively within a properly ventilated fume hood or laminar flow cabinet. Required PPE: nitrile gloves (double-glove for powder handling), lab coat, safety glasses, and N95 respirator when weighing to prevent inhalation of fine particulates. GABA-A agonist compounds require particular attention to dermal absorption risk — ensure glove integrity throughout all handling operations. Anti-static weighing vessels recommended for accurate sub-milligram measurements. Spill containment: absorb with inert material, collect in sealed container, dispose per institutional chemical waste procedures. Emergency: if skin contact, wash thoroughly with soap and water; if eye contact, flush with water for 15 minutes and seek medical attention. Maintain compound log documenting lot number, date received, date opened, quantity used — required for research traceability and audit compliance.

Packaging, Labeling & Storage

Etizolam research chemical is supplied in sealed amber glass vials with inert closures and desiccant packs, in discreet external packaging suitable for laboratory receipt. Labels specify compound name, CAS 40054-69-1, lot number, purity, and research use notice. Recommended storage: -20°C long-term; ≤25°C short-term (active use, max 2 weeks, desiccated, sealed). Amber glass vials protect against UV photodegradation. Avoid polystyrene containers. Under recommended conditions, stability maintained for the lot expiry period stated on the COA.

Intended Research Use & Market Positioning

Etizolam research chemical is positioned as a primary reference standard for: forensic toxicology laboratories developing validated LC-MS/MS screening methods for thienodiazepine detection in biological matrices; GABA-A receptor subtype binding affinity studies examining the pharmacological impact of thieno versus benzo ring system differences; in-vitro metabolite identification programs characterizing etizolam Phase I and II biotransformation pathways using HLM and recombinant CYP enzyme preparations; plasma protein binding characterization studies; and comparative pharmacokinetic profiling programs examining structural determinants of intermediate-acting thienodiazepine half-life profiles. Browse related benzodiazepine and thienodiazepine reference compounds at ultrarawz.com — Benzodiazepines.

Ordering, Availability & Fulfillment

Etizolam research chemical is available in multiple formats and quantities — see product variants above for current options and pricing. Payment methods include Bitcoin (BTC), bank transfer, Interac E-Transfer (Canada), Apple Pay (US), Zelle (US), Chime (US), Revolut (Europe), and gift cards — full details at ultrarawz.com/payment. Orders processed same day with discreet, secure packaging. Worldwide shipping from US and Netherlands warehouses. Typical delivery: 2–5 business days (US/EU); 5–10 business days international. Bulk institutional pricing and COA pre-purchase requests: support@ultrarawz.com or WhatsApp +1 (567) 457-7456. Track at ultrarawz.com/track-order.

Legal & Regulatory Disclaimer

Etizolam (CAS 40054-69-1) is supplied strictly for laboratory research purposes only. Not for human or veterinary use. Not for clinical, diagnostic, or consumptive applications. Legal status varies by jurisdiction: etizolam is not federally scheduled under the US Controlled Substances Act but is controlled in several US states (Alabama, Arkansas, Florida, Georgia, Indiana, Louisiana, Mississippi, Texas, Virginia). It has approved pharmaceutical use in Japan and India. Purchasers are solely responsible for verifying and complying with all applicable regulations prior to ordering. UltraRawz supplies this compound exclusively to qualified research professionals.

Frequently Asked Questions

Q: What makes etizolam a thienodiazepine rather than a benzodiazepine?
A: Etizolam incorporates a thiophene ring (containing sulfur) in place of the benzene ring found in classical benzodiazepines. This structural difference produces distinct HPLC retention behavior, unique NMR thiophene signals, and measurable differences in GABA-A receptor subtype selectivity — making etizolam a valuable comparative reference compound in SAR research.

Q: What LC-MS/MS transitions are used for etizolam?
A: MRM quantifier: 343→314 (loss of 29 Da ethyl fragment); qualifier: 343→296. These published transitions are widely used in validated forensic screening methods for etizolam in urine and blood matrices.

Q: What purity does UltraRawz etizolam achieve?
A: ≥98% by HPLC area normalization. Batch-specific COA available on request with HPLC chromatogram and NMR identity data.

Q: Is etizolam legal to purchase for research?
A: Etizolam is not federally controlled in the US but is controlled in several states. Legal status varies internationally. Purchasers are responsible for verifying regulations in their jurisdiction before ordering.

Q: What storage conditions are required?
A: -20°C long-term in amber glass with desiccant. ≤25°C short-term (max 2 weeks, sealed, desiccated). Protect from UV light.

Q: Can I get a COA before purchasing?
A: Yes. Contact support@ultrarawz.com to request COA documentation for the current lot prior to purchase.

Q: What related compounds does UltraRawz carry?
A: We carry a full range of benzodiazepine and thienodiazepine research compounds including bromazolam, clonazolam, flualprazolam, diclazepam, flubromazepam, and flubromazolam. Browse at ultrarawz.com — Benzodiazepines.