Buy Bromazolam Pellets 3mg

Product Overview

Bromazolam (CAS 71368-80-4) supplies researchers with a high-purity triazolobenzodiazepine reference standard for forensic toxicology analytical method development, GABA-A receptor binding studies, and designer benzodiazepine structure-activity relationship research within controlled laboratory environments. Researchers looking to buy bromazolamfor laboratory applications will find UltraRawz’s HPLC-verified material suitable for LC-MS/MS MRM method development and validation, in-vitro GABA-A receptor subtype binding affinity profiling, metabolite identification studies using human liver microsome preparations, and multi-compound forensic benzodiazepine screening panel construction. Bromazolam has emerged as one of the most frequently detected designer benzodiazepines in European and North American forensic submissions since 2020, generating significant demand for authenticated reference standards from toxicology laboratories developing and validating screening methodologies for clinical and postmortem case work. For research use only. Not for human or veterinary use. Not for clinical, diagnostic, or consumptive applications.

Bromazolam is structurally related to alprazolam — sharing the triazolo ring fusion at the 1,2-position and 2-chlorophenyl substituent at C-5 — but substitutes a bromine atom at the C-8 position rather than alprazolam’s fluorine at C-8. This bromine substitution confers a distinctive mass spectrometric signature: the characteristic ⁷⁹Br/⁸¹Br isotope doublet pattern (approximately 1:1 M/M+2 ratio) visible in both full-scan MS and product ion spectra provides an unambiguous analytical marker for bromine-containing compounds that distinguishes bromazolam from structurally related non-brominated triazolobenzodiazepines. This isotope pattern is exploited in published forensic method development for rapid library-based identification of bromazolam in complex biological matrices. Bromazolam for sale at UltraRawz ships worldwide with discreet packaging and same-day order processing from US and Netherlands warehouses.

Each batch of bromazolam research compound at ultrarawz.com/shop is HPLC-verified at ≥98% purity with batch-specific COA documentation including NMR identity confirmation. Related triazolobenzodiazepine and designer benzodiazepine reference compounds at UltraRawz include clonazolam, flualprazolam, flunitrazolam, etizolam, diclazepam, flubromazepam, and flubromazolam — browse the complete benzodiazepine research panel at ultrarawz.com — Benzodiazepines.

Chemical Identity & Classification

Bromazolam carries CAS number 71368-80-4, molecular formula C₁₇H₁₄BrClN₄, and molecular weight 414.68 g/mol. Systematic IUPAC designation: 8-bromo-1-methyl-6-(2-chlorophenyl)-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine. Laboratory synonyms: XLI-268, bromazolam. Structural classification: triazolobenzodiazepine — triazolo ring fusion at 1,2-position, 2-chlorophenyl at C-5, bromine at C-8, methyl at N-1. The dual halogenation (Br at C-8, Cl on 2-phenyl) produces the diagnostic bromine isotope doublet pattern in MS spectra and distinct ¹H NMR aromatic proton patterns. Protonated molecular ion [M+H]⁺: m/z 415/417 (⁷⁹Br/⁸¹Br doublet, ~1:1 ratio). PubChem CID: 12673845. ChemSpider ID: 10597018.

Chemical & Physical Characteristics

Bromazolam manifests as white to off-white crystalline powder with melting point approximately 215–218°C. DMSO solubility: ≥5 mg/mL. Methanol and ethanol: soluble. Aqueous solubility: sparingly soluble (high logP, ~4.0 calculated — among the more lipophilic designer benzodiazepines). UV absorption: ~230–240 nm (triazolobenzodiazepine chromophore). The high lipophilicity relative to alprazolam (logP ~2.1) produces measurably different plasma protein binding behavior — an important variable in forensic pharmacokinetics research. Hygroscopicity: low to moderate — less hygroscopic than cathinone HCl salts but store with desiccant as standard practice. Amber glass storage recommended — benzodiazepine photostability varies by substitution; bromine-containing compounds may show UV-induced radical chemistry. For LC-MS/MS work, prepare 1 mM stock solutions in methanol or acidified acetonitrile.

Purity & Analytical Verification

Production lots certify ≥98% purity by gradient HPLC (C18 reverse-phase, acetonitrile/0.1% formic acid gradient, UV 230 nm, area normalization). Identity confirmed by: ¹H NMR (CDCl₃) showing characteristic triazolo CH at δ ~9.0–9.2 ppm, 2-chlorophenyl aromatic protons at δ 7.3–7.6 ppm, and C-8 position without aromatic proton (confirming bromine at C-8, distinguished from alprazolam which has H at C-8 and F at ring). MS: protonated molecular ion [M+H]⁺ at m/z 415/417 with ~1:1 ⁷⁹Br/⁸¹Br isotope ratio — diagnostic bromine signature. LC-MS/MS MRM quantifier: 415→313 (loss of 102, CHBrN₂); qualifier: 415→277. GC-MS: derivatization with TMS recommended. Karl Fischer water content: <1.0% w/w. COA available on request at support@ultrarawz.com.

Quality Control & Batch Integrity

Each production batch undergoes multi-stage quality verification: HPLC purity assessment, ¹H NMR identity confirmation (triazolo CH and aromatic pattern verification), MS bromine isotope ratio verification (⁷⁹Br/⁸¹Br ~1:1 confirmed), Karl Fischer water content, and visual appearance assessment. Bromine isotope ratio verification is a batch-specific release criterion — confirmed isotope pattern provides additional identity confidence beyond standard HPLC purity data. Batch-specific lot numbers enable full traceability. Retained reference samples support stability monitoring and reanalysis capability.

Safety, Handling & Laboratory Precautions

Handle exclusively within a properly ventilated fume hood or biosafety cabinet. Required PPE: nitrile gloves (double-glove), lab coat, safety glasses, N95 respirator when handling powder. GABA-A agonist — high lipophilicity increases potential for dermal absorption versus more polar benzodiazepine analogues; verify glove integrity throughout all handling. Anti-static weighing vessels recommended for sub-milligram accuracy. Avoid contact with strong reducing agents that may reduce or cleave the C-Br bond. Spill: absorb with inert material, collect in sealed container, dispose per institutional chemical waste procedures. Emergency: skin contact — wash with soap and water; eye contact — flush 15 minutes, seek medical attention. Maintain compound usage log with lot number, date received, quantities dispensed.

Packaging, Labeling & Storage

Bromazolam research compound is supplied in sealed amber glass vials with inert closures and desiccant packs, in discreet external packaging. Labels specify compound name, CAS 71368-80-4, lot number, purity, and research use notice. Recommended storage: -20°C long-term; ≤25°C short-term (active use, max 2 weeks, desiccated, sealed). Amber glass mandatory — bromine-containing benzodiazepine analogues may show UV-induced radical degradation pathways under prolonged light exposure. Under recommended conditions, compound integrity maintained for the lot expiry period stated on the COA.

Intended Research Use & Market Positioning

Bromazolam research compound is positioned for: forensic toxicology laboratories developing and validating LC-MS/MS identification methods for bromazolam detection in urine, blood, hair, and postmortem matrices; GABA-A receptor subtype binding affinity studies comparing bromine versus fluorine substitution effects at C-8 of the triazolobenzodiazepine scaffold; in-vitro metabolite identification programs characterizing bromazolam Phase I biotransformation using HLM and recombinant CYP3A4 enzyme systems; multi-compound designer benzodiazepine screening panel construction for clinical and forensic NPS surveillance programs; and comparative SAR studies examining C-8 halogen substitution effects on triazolobenzodiazepine receptor selectivity and pharmacokinetic profiles. Browse related compounds at ultrarawz.com — Benzodiazepines.

Ordering, Availability & Fulfillment

Bromazolam research compound is available in multiple formats and quantities — see product variants above for current pricing. Payment methods: Bitcoin (BTC), bank transfer, Interac E-Transfer (Canada), Apple Pay (US), Zelle (US), Chime (US), Revolut (Europe), gift cards — full details at ultrarawz.com/payment. Orders processed same day with discreet, secure packaging. Worldwide shipping from US and Netherlands warehouses. Delivery: 2–5 business days (US/EU); 5–10 business days international. Institutional pricing and COA requests: support@ultrarawz.com or WhatsApp +1 (567) 457-7456. Track at ultrarawz.com/track-order.

Legal & Regulatory Disclaimer

Bromazolam (CAS 71368-80-4) is supplied strictly for laboratory research purposes only. Not for human or veterinary use. Not for clinical, diagnostic, or consumptive applications. Regulatory status varies by jurisdiction — bromazolam is controlled in several countries and US states. Purchasers are solely responsible for verifying and complying with all applicable regulations prior to ordering. UltraRawz supplies this compound exclusively to qualified research professionals for legitimate laboratory research purposes.

Frequently Asked Questions

Q: How does the bromine isotope pattern help identify bromazolam?
A: Bromine has two naturally occurring isotopes (⁷⁹Br and ⁸¹Br) in approximately 1:1 abundance ratio. This produces a characteristic M/M+2 doublet pattern in full-scan MS spectra at m/z 415/417 that is immediately recognizable and unambiguous — no non-brominated compound can produce this pattern. It allows rapid presumptive identification of bromazolam from full-scan data before MRM confirmation.

Q: What is the structural relationship between bromazolam and alprazolam?
A: Both are triazolobenzodiazepines with triazolo ring fusion at the 1,2-position and 2-chlorophenyl at C-5. The key difference: alprazolam has no halogen at C-8, while bromazolam has bromine at C-8. This C-8 bromine substitution is responsible for the higher molecular weight (414.68 vs 308.76 g/mol) and the distinctive MS isotope pattern.

Q: What purity does UltraRawz bromazolam achieve?
A: ≥98% by HPLC area normalization. Batch-specific COA with HPLC chromatogram, NMR data, and bromine isotope ratio confirmation available on request.

Q: What LC-MS/MS transitions are used for bromazolam?
A: MRM quantifier: 415→313; qualifier: 415→277. Monitor both ⁷⁹Br and ⁸¹Br isotopologue pairs for additional confirmation confidence in method validation work.

Q: Can I get a COA before purchasing?
A: Yes. Email support@ultrarawz.com to request current lot COA documentation.

Q: What related benzodiazepines does UltraRawz carry?
A: Full designer benzodiazepine panel including clonazolam, flualprazolam, flunitrazolam, etizolam, diclazepam, flubromazepam, flubromazolam, and norflurazepam. Browse at ultrarawz.com — Benzodiazepines.

Q: Do you ship internationally?
A: Yes, worldwide from US and Netherlands. Purchasers must verify local regulations before ordering. See shipping & delivery.