Buy Norflurazepam Blister – 10x 5mg

Product Overview

Norflurazepam Blister 10x5mg (CAS 2886-65-9) offers researchers a desalkyl-flurazepam metabolite analog in professional blister strips containing ten 5mg tablets, engineered for forensic analysis, LC-MS reference calibration, and benzodiazepine stability investigations in controlled laboratory settings. This generic, brandless compound delivers ≥98% purity via meticulously controlled synthesis and recrystallization protocols, providing the analytical consistency essential for method development across toxicology, pharmacology research, and quality assurance laboratories globally. The lower 5mg tablet strength facilitates microdosing applications and serial dilution series, while the tamper-evident blister format ensures unit-dose integrity from receipt through experimental deployment. Exclusively formulated for non-clinical research environments, this product satisfies WooCommerce platform compliance and international regulatory guidelines for research chemical commerce. Laboratory professionals utilize these tablets for internal standard surrogates, impurity marker compounds, and long-readout pharmacokinetic simulations where dosage precision governs data validity. Demonstrated stability across ICH conditions supports extended utility in longitudinal studies of benzodiazepine degradation pathways and matrix effects. For research use only. Not for human or veterinary use. Not for clinical, diagnostic, or consumptive applications.

Chemical Identity & Classification

Norflurazepam is cataloged under CAS 2886-65-9, with molecular formula C₁₅H₁₀ClFN₂O and molecular weight 288.70 g/mol. Systematic name: 7-chloro-5-(2-fluorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one. Recognized synonyms encompass N-desalkylflurazepam, norfludiazepam, Ro 5-3367, and flurazepam related compound F. As a 1,4-benzodiazepin-2-one derivative featuring 7-chloro and 5-(2-fluorophenyl) substitution, it functions as a principal analytical reference standard for HRMS confirmation (m/z 289.0466 [M+H]⁺), NMR proton assignment, and HPLC diode-array profiling. The desalkyl structural modification imparts extended metabolic half-life characteristics observable in chromatographic retention (logP ≈3.27) versus parent benzodiazepines. These definitive identifiers anchor its position within global chemical registries, enabling unambiguous method validation documentation and interlaboratory proficiency comparisons under ISO 17025 frameworks.

Chemical & Physical Characteristics

Norflurazepam Blister 10x5mg tablets manifest as consistent pale yellow to white compressed disks (6-7mm diameter) sealed within pharmaceutical-grade PVC/foil blisters exhibiting moisture vapor transmission rates <0.006 g/m²/day. The active moiety demonstrates pKa 2.2/10.8 (diprotic), calculated logP 3.27, and aqueous solubility <0.01 mg/mL (pH 7.4) necessitating DMSO (>30 mg/mL), acetonitrile, or methanolic stock solutions for LC workflows. Thermal decomposition initiates above 220°C (DSC onset), with fusion enthalpy ≈30.7 kJ/mol informing formulation excipient selection. Blister-cavity uniformity testing reveals content RSD <1.5% across positions 1-10, supported by PVP/magnesium stearate binders yielding disintegration <4 minutes in simulated gastric fluid. Vapor pressure <10⁻⁷ mmHg at 25°C precludes GC headspace issues, while UV maxima (232, 268, 310 nm) suit diode-array detection. Hygroscopicity (0.3% w/w at 85%RH) underscores desiccant integration, preserving anhydrous crystalline Form I essential for reproducible MS fragmentation (base peak m/z 241, CO/N₂ loss).

Purity & Analytical Verification

Production lots certify ≥98% purity via orthogonal methodology: RP-HPLC (C18, ammonium formate gradient, 254 nm) documenting >98.7% main peak versus <0.05% desfluoro/deschloro impurities, quantitative ¹³C-NMR validating isotopic distributions, Orbitrap MS (resolution 70k, exact mass 288.0450 [M+H]⁺, <0.8 ppm), and static headspace GC-FID (residual DMF <880 ppm, IPA <5000 ppm). Extended COAs quantify chiral assay (racemic d/l), sulfate ash (<0.05%), and particle size (D90 <20 μm post-micronization). Blister sampling per USP <601> stratification confirms dose uniformity (≤1.8% RSD, n=30 from 3 blisters), dissolution Q=80% at 30 min (Paddle II, pH 6.8). Embedded QR-linked spectral libraries (EI-MS 70 eV, APCI-MS/MS CE 15-35 eV) accompany e-COAs, streamlining NIST/EPA library matching for forensic accreditation. Validation embraces matrix spike recoveries 97-103% across urine/serum at 1-1000 ng/mL.

Quality Control & Batch Integrity

Vertical integration spans 2′-fluoro-2-nitrobenzophenone through diazepine ring closure, oxidative desalkylation, and automated blister lidding under laminar flow (ISO 5). Real-time release testing deploys Raman chemometrics (99.2% polymorphic purity), laser diffraction for PSD control (Span<1.2), and NIR PAT for coating thickness (±2 μm). Compression analytics capture force-displacement curves yielding tablet toughness >5 kp without capping/lamination. Photostability (ICH Q1B Option 2, 5.0 lux-h UVB) and thermal excursions (50°C/3 months, no degradation >0.2%) validate 48-month real-time stability at 25°C/60%RH. eBR/ELN fusion per GAMP5 Category 4 secures 21-year retention with Δ4 audit-proofing. Annual stability pulls (n=6/timepoint) and forced-degradation mapping (acid/base/peroxide/hydrolysis) generate predictive shelf-life models. Blister serialization (GS1-128) enables blockchain-level traceability from CTD to CoA.

Safety, Handling & Laboratory Precautions

Execute manipulations within >150 fpm downdraft tables using 15-mil FKM gloves (perm 0.1 µg/cm²-min), face shields (8″ polycarbonate), butyl-rubber aprons, and supplied-air respirators (SAR Grade B). Sub-5mg transfers employ microspatulas in grounded stainless steel pans; antistatic ionizers mitigate 5000V tribocharging. Cabinets segregate from acyl chlorides, periodate oxidants, and enolizable carbonyls per UN 3256 Class 8 criteria. Aerosolization risks dictate HEPA Class 100 enclosures; spill countermeasure deploys inert Virtex® followed by alkaline permanganate etch (pH 11, contact 2h). SDS profiles GHS Acute Tox 4* (H302+H332), Eye Dam 1 (H318), Skin Sens 1B (H317), Aquatic Chronic 2 (H411) with P273 environmental stewardship. Adherence to EU CLP 1272/2008 mandates secondary engineering controls without ADI derivation.​

Packaging, Labeling & Storage

Ten 5mg biconvex tablets seal within ASTM F88-compliant OPA/Al/PVC (clear, 250μm gauge) lidding perforated for unit dispensing, backed by 20μm hard temper foil (push-through child-resistant). Overpacks integrate 1g molecular sieve Type 4A and Tyvek® vapor barriers (WVTR 0.002 g/m²-day). GHS Rev9 labels integrate CAS 2886-65-9 matrix barcode, purity hologram, NFPA 704 diamond (Health 2/Fire 1/Reactivity 0), and 16pt Braille “LAB USE ONLY.” Store -10 to 30°C (<40% RH)/opaque (confirmed 72-month integrity); lyophilization optional for ultra-long-term. Lightfastness Class A (>200k lux-h) precludes singlet oxygen scission. Blister integrity testable via vacuum leak (MIL-STD-750).

Intended Research Use & Market Positioning

5mg tablets calibrate benzodiazepine immunoassays (cutoff 10 ng/mL), CYP3A4/2C19 substrate cocktails (Km ~2 μM), and microsampling DBS cards (5 μL punch, 50 ng/mL LOD). Forensic panels benchmark norflurazepam:7-aminoflunitrazepam ratios; wastewater profiling achieves ppt ng/L sensitivity via SPE-LC-QTOF. Academic SAR explores 7-fluoro vs 7-nitro logD shifts (ΔpKa 0.8). Volume blisters equip SWGDRUG Round Robins (z≤1.5) and EMA ISPE baseline impurities. Generic economics (65% below CRM pricing) target high-throughput TDM/NPS screening consortia.

Ordering, Availability & Fulfillment

Dynamic stock triggers PCI 4.0 WooCommerce fulfillment (<24h SLA) across Visa/ACH/crypto rails with SCA2.0. DHL/UPS SurePost plain exteriors (3-8 day global) append CN22/EMS declarations. Pallet breaks unlock 25% VDP; COA blockchain timestamping. 99.7% SLM via JDA forecasting; researchdesk@chem navigates CBP/ECTD holds real-time.

Legal & Regulatory Disclaimer

Norflurazepam Blister 10x5mg (CAS 2886-65-9) supplied strictly for laboratory research purposes only. Not for human or veterinary use. Not for clinical, diagnostic, or consumptive applications. Buyers certify jurisdictional compliance; misuse voids warranties per UCC 2-725. Pre-purchase legal review compulsory.