Product Overview

SR-9011 powder is a brandless, high-purity research compound chemically designated as 3-[[[(4-chlorophenyl)methyl][(5-nitro-2-thienyl)methyl]amino]methyl]-N-pentyl-1-pyrrolidinecarboxamide, supplied exclusively for analytical laboratory and investigative research purposes. It is provided to qualified laboratories, academic institutions, and R&D facilities needing a verified REV-ERB agonist reference material for in vitro assays, chromatographic characterization, and receptor binding studies. Manufactured to ≥98% purity specifications, each batch undergoes rigorous analytical confirmation with full documentation support for laboratory integration.

This generic powder form is unbranded and positioned strictly as a research reagent, suitable for non-clinical applications such as nuclear receptor profiling or circadian rhythm model development in controlled environments. No associations with therapeutic outcomes, administration protocols, or biological testing beyond pure analytical contexts are implied or supported. For research use only. Not for human or veterinary use. Not for clinical, diagnostic, or consumptive applications.

Chemical Identity & Classification

SR-9011 is classified as a synthetic REV-ERBα/β agonist research chemical, serving as an analytical reference standard in nuclear receptor and chronobiology studies. It functions within laboratory frameworks exploring gene regulation mechanisms without clinical implications.

Key identifiers include:

• Synonyms: SR9011; SR-9011; 3-[[[(4-chlorophenyl)methyl][(5-nitro-2-thienyl)methyl]amino]methyl]-N-pentyl-1-pyrrolidinecarboxamide

• CAS number: 1379686-29-9

• Molecular formula: C23H31ClN4O3S

• Molecular weight: 479.04 g/mol

These details ensure accurate inventory management, spectroscopic matching, and protocol documentation in professional research settings.

Chemical & Physical Characteristics

SR-9011 powder typically appears as a white to beige crystalline solid, consistent with its formulation for stability in analytical storage and handling. The fine powder morphology supports precise gravimetric preparation, dissolution, and aliquoting for laboratory stock solutions or calibration standards.​

Solubility profiles include good compatibility with DMSO (up to 30 mg/mL), DMF, and ethanol, facilitating preparation in common organic media used for cell-free assays or chromatographic mobile phases. Aqueous solubility is limited, as expected for this lipophilic structure, requiring empirical verification for specific method conditions. Physical stability under inert conditions minimizes degradation risks during extended storage.

Purity & Analytical Verification

This SR-9011 powder meets or exceeds ≥98% purity, confirmed through validated methods such as high-performance liquid chromatography (HPLC ≥98%), liquid chromatography-mass spectrometry (LC-MS), nuclear magnetic resonance (NMR), and UV-Vis spectroscopy (λmax 325 nm). These techniques quantify main component levels, detect process impurities, and verify structural identity against reference spectra.

Lot-specific certificates of analysis (COAs) report detailed chromatograms, mass spectra, and purity metrics, enabling seamless incorporation into quality-controlled workflows. Researchers can cross-validate COA data with in-house instrumentation to establish method suitability for quantitative applications like dose-response curves or impurity profiling. Independent third-party testing may supplement internal assays for heightened assurance in multi-site collaborations.

Quality Control & Batch Integrity

Batch production assigns unique lot identifiers to every powder release, creating an unbroken chain of custody from synthesis through final packaging and distribution. Comprehensive QC encompasses raw material incoming inspection, in-process monitoring, final purity/identity release testing, and stability-indicating assessments to confirm shelf-life integrity.​

Third-party analytical laboratories provide orthogonal verification where protocol demands, ensuring objectivity in critical parameters like enantiomeric purity or isotopic distribution if applicable. Retained reference samples per lot support retrospective re-analysis, fostering trust in long-term experimental reproducibility across serial purchases. This disciplined approach aligns with GLP-like standards suitable for grant-funded or regulatory-adjacent research programs.

Safety, Handling & Laboratory Precautions

SR-9011 powder requires manipulation solely by trained chemists in certified fume hoods or biosafety cabinets to control potential dust generation and vapor exposure. Essential PPE includes chemical-resistant gloves (nitrile), full-face shields, impermeable lab coats, and optional respiratory protection based on airborne concentration risk assessments.​

Prior review of the Material Safety Data Sheet (MSDS/SDS) is mandatory, detailing GHS classifications, incompatibility lists (e.g., strong acids/bases), and emergency decontamination steps. Institutional chemical hygiene plans dictate secondary containment, spill mitigation, and hazardous waste segregation; no toxicological endpoints, exposure limits, or medical countermeasures are addressed here.

Packaging, Labeling & Storage

Dispensed into amber glass vials or polyethylene containers with PTFE-lined caps, engineered for low-permeation protection against moisture ingress, photodegradation, and oxidative stress. Each unit bears compliant labels with product nomenclature, CAS registry, lot code, purity declaration, UN hazard class if applicable, and NFPA ratings for rapid identification.​

Optimal storage employs -20°C freezers under desiccated, nitrogen-purged headspaces, minimizing hydrolytic or thermal decomposition pathways. Ambient excursions should be brief; always prioritize batch COA-specified excursions and requalification thresholds to maintain analytical fidelity over project timelines.

Intended Research Use & Market Positioning

SR-9011 powder targets chronobiology labs, nuclear receptor pharmacology groups, and metabolic research facilities developing REV-ERB-targeted assays or circadian oscillator models. It supports applications in gene reporter systems, high-throughput screening platforms, and quantitative structure-activity relationship (QSAR) analyses for agonist optimization.

Marketed exclusively as a laboratory reagent, it carries no suitability for human/animal models, diagnostic panels, or therapeutic lead progression. For research use only. Not for human or veterinary use. Not for clinical, diagnostic, or consumptive applications.

Ordering, Availability & Fulfillment

Stocked for immediate purchase through compliant eCommerce interfaces with real-time inventory visibility and lot-select options for preferred release dates. Secure payment processing integrates with global gateways, followed by insulated, tamper-evident packaging and carrier-tracked dispatch.​

Dedicated support facilitates COA/SDS digital delivery, bulk quote generation, and non-clinical technical consultations to streamline procurement for high-volume or recurrent orders. Fulfillment prioritizes FIFO rotation to deliver freshest material, minimizing age-related variability risks.

Legal & Regulatory Disclaimer

SR-9011 powder constitutes a research chemical for bona fide laboratory investigations, devoid of any food, drug, cosmetic, or supplement designations under prevailing regulations. No IND filings, NDA pathways, or clinical trial endorsements apply. Acquirers bear sole accountability for jurisdictional conformity in procurement, possession, manipulation, and disposition.

For research use only. Not for human or veterinary use. Not for clinical, diagnostic, or consumptive applications.