Product Overview

SR-9009 powder, commonly known as Stenabolic, is a brandless research-grade compound chemically identified as ethyl 3-[[[(4-chlorophenyl)methyl][(5-nitro-2-thienyl)methyl]amino]methyl]-1-pyrrolidinecarboxylate, provided exclusively for analytical laboratory and investigative research purposes. It serves qualified research institutions, pharmaceutical R&D laboratories, and analytical facilities needing a verified REV-ERB agonist analog for in vitro binding studies, chromatographic method development, and structural characterization workflows. Each batch is manufactured to meet or exceed ≥98% purity standards, supported by comprehensive analytical verification including certificates of analysis (COAs) for laboratory quality integration.

As an unbranded generic reagent, SR-9009 powder (Stenabolic) is positioned strictly for non-clinical research applications such as nuclear receptor profiling, circadian rhythm model characterization, and quantitative analytical method validation. No implications for biological testing, therapeutic applications, or administration protocols are intended or supported. For research use only. Not for human or veterinary use. Not for clinical, diagnostic, or consumptive applications.

Chemical Identity & Classification

SR-9009 powder (Stenabolic) is classified as a synthetic REV-ERBα/β agonist research chemical, serving as an analytical reference standard in chronobiology, nuclear receptor pharmacology, and metabolic pathway investigations. Its substituted pyrrolidinecarboxylate structure with nitrothiophene and chlorophenyl moieties distinguishes it within REV-ERB modulator analog series for laboratory structural studies.

Key identifiers include:

• Synonyms: SR9009; SR-9009; Stenabolic; REV-ERB Agonist II

• CAS number: 1379686-30-2

• Molecular formula: C20H24ClN3O4S

• Molecular weight: 437.94 g/mol

These specifications facilitate precise cataloging in laboratory information management systems (LIMS), mass spectral library matching, and standardized documentation across collaborative research protocols.

Chemical & Physical Characteristics

SR-9009 powder (Stenabolic) typically appears as a white to off-white crystalline solid, optimized for analytical stability and handling in powder form. The fine crystalline morphology supports accurate gravimetric dispensing, dissolution into stock solutions, and aliquoting for high-throughput screening or calibration standards under controlled laboratory conditions.​

Solubility profiles demonstrate excellent compatibility with DMSO (>25 mg/mL, 575.42 mM with sonication), ethanol (up to 20 mg/mL), and DMF, enabling versatile formulation for cell-free assays, reporter gene systems, or liquid chromatography applications. Aqueous solubility remains limited due to its lipophilic character, requiring cosolvent strategies for buffered systems; empirical profiling under specific ionic strength and pH conditions is recommended. Melting point ranges 79-81°C with predicted boiling point 547.2°C and density 1.327 g/cm³ inform thermal handling parameters. Physical stability under desiccated conditions minimizes degradation during extended storage.

Purity & Analytical Verification

Guaranteed ≥98% purity through orthogonal methods including high-performance liquid chromatography (HPLC), liquid chromatography-mass spectrometry (LC-MS), nuclear magnetic resonance (NMR) spectroscopy, and UV-Vis analysis. These techniques confirm chemical identity via molecular ion matching, quantify synthetic impurities and degradation products, assess polymorphic form consistency, and verify solvates or hydrates against reference standards.

Batch-specific COAs detail peak purity ratios, mass fragmentation patterns, proton NMR chemical shift assignments, and residual solvent headspace GC compliant with ICH Q3C limits. Documentation supports method validation, instrument qualification, and data integrity requirements in professional research environments. Availability of raw spectral datasets enables custom re-quantification and facilitates electronic laboratory notebook integration for reproducible workflows. Third-party orthogonal testing provides additional verification for multi-site collaborations or proficiency demonstrations.

Quality Control & Batch Integrity

Batch-controlled manufacturing assigns unique alphanumeric lot codes across primary containers, analytical records, and shipping manifests, establishing complete end-to-end traceability. Quality protocols encompass vendor-audited raw materials, in-process reaction monitoring via TLC/HPLC, intermediate isolation purity checks, final API release testing, and forced degradation studies per ICH Q1B guidelines simulating light, heat, humidity, acid/base, and oxidative stress.​

Statistical process control maintains critical quality attribute consistency including enantiomeric purity (where applicable), particle size distribution (D50 <10 μm), and moisture content (<1% KF). Retained engineering batches bridge production campaigns, essential for longitudinal metabolic or circadian studies spanning multiple years. Internal quality units exercise independence in release authority, with optional compendial IR/UV spectral matching against pharmacopeial references enhancing documentation suitability for institutional grants or CRO transfers.

Safety, Handling & Laboratory Precautions

SR-9009 powder (Stenabolic) demands certified fume hood or glovebox manipulation by trained synthetic chemists to preclude aerosol formation, dermal penetration, or inhalation exposure. Essential PPE comprises 15-mil nitrile gloves, chemical splash goggles (ANSI Z87+), Tyvek gowns, and P100-filtered half-face respirators for transfers exceeding milligram scales. Local exhaust maintains airborne particulates below internal action levels with HEPA filtration as secondary containment.​

Pre-use Safety Data Sheet (SDS) consultation details GHS classifications (H302, H312, H332, H360), reactivity hazards with strong oxidizers/nucleophiles, and spill mitigation integrating diatomaceous earth absorption followed by methanol extraction. Hazardous waste streams classify per RCRA F-list criteria with incineration validation; no occupational exposure limits, ADI values, or antidote protocols are specified or implied. Institutional chemical hygiene programs govern all procedural deviations and exposure incident responses.

Packaging, Labeling & Storage

Primary containment employs amber USP Type I glass vials with PTFE/silicone septa and crimp seals, providing inert barrier protection against moisture permeation, photodegradation of nitroaromatic chromophores, and oxidative thioether metabolism. Secondary overwrap utilizes desiccated foil pouches with oxygen absorbers for bulk transit resilience. GHS-compliant labels encode IUPAC nomenclature, CAS identifier, lot/NFPA ratings, supplemental P- and H-statements, and QR-linked digital COA portals.​

Refrigerated storage (2-8°C, <30% RH) under nitrogen headspace preserves integrity over 24-36 months; -20°C extends beyond-project utility. Photoprotective secondary containers mitigate singlet oxygen pathways. HPLC stability-indicating assays monitor active content quarterly, dictating requalification schedules. Segregate from alkalies, reducing sugars, and transition metals precluding complexation or precipitation.

Intended Research Use & Market Positioning

SR-9009 powder (Stenabolic) enables REV-ERB pharmacodynamic modeling, circadian oscillator disruption studies, mitochondrial biogenesis pathway interrogation, and high-content metabolic flux screening in preclinical discovery platforms. Nanomolar potency supports TR-FRET coactivator recruitment assays, Bmal1 promoter luciferase reporting, and quantitative PCR validation of clock gene oscillations (Per2, Cry1) in synchronized cell models.

Designated solely as analytical reference material, it excludes applicability to animal models, human trials, veterinary therapeutics, diagnostic development, or IND-enabling packages. For research use only. Not for human or veterinary use. Not for clinical, diagnostic, or consumptive applications.

Ordering, Availability & Fulfillment

Immediate procurement via secure eCommerce with tiered milligram-to-gram scaling accommodates academic proof-of-concept through biotech optimization phases. PCI-compliant checkout orchestrates global payments, automated export screening per Wassenaar controls, and digital chain-of-custody manifests. Cold-chain fulfillment (2-8°C) utilizes insulated carriers with real-time temperature dataloggers and RFID tracking.​

Ancillary services encompass autosampler-ready aliquoting, deuterium-labeled internal standard pairing for LC-MS quantitation, and custom salt form screening panels. Account managers deliver non-GxP solubilization guidance, counterion stability rankings, and orthogonal analytics recommendations. FIFO lot rotation ensures campaign-fresh material, stabilizing potency specifications across serial orders.

Legal & Regulatory Disclaimer

SR-9009 powder (Stenabolic) qualifies exclusively as research chemical absent FDA/EMA approvals, dietary ingredient notifications, novel food authorizations, or cGMP manufacturing declarations. No claims address pyrogenicity, bioburden limits, or elemental impurities per ICH Q3D. Acquirers certify institutional authorization, legitimate research intent, and jurisdictional compliance encompassing DEA analogs, EU novel substance notifications, and TSCA positive listings where applicable.

For research use only. Not for human or veterinary use. Not for clinical, diagnostic, or consumptive applications.