Product Overview

S-23 powder is a brandless research-grade compound chemically identified as (S)-3-(4-chloro-3-fluorophenoxy)-N-(4-cyano-3-(trifluoromethyl)phenyl)-2-hydroxy-2-methylpropanamide, provided exclusively for analytical and laboratory investigative purposes. It serves qualified research institutions, pharmaceutical R&D laboratories, and analytical facilities needing a verified SARM analog for in vitro receptor binding assays, chromatographic profiling, and structural characterization studies. Each batch is manufactured to meet or exceed ≥98% purity standards, supported by comprehensive analytical documentation including certificates of analysis (COAs) for seamless laboratory integration.

As an unbranded generic reagent, S-23 powder is positioned strictly for non-clinical research workflows such as method development, quantitative analysis, and reference standard preparation. No implications for biological testing, therapeutic applications, administration routes, or performance outcomes are made or supported. For research use only. Not for human or veterinary use. Not for clinical, diagnostic, or consumptive applications.

Chemical Identity & Classification

S-23 powder is classified as a nonsteroidal selective androgen receptor modulator (SARM) research chemical, utilized as an analytical reference in pharmacology and receptor studies. Its specific stereochemistry and functional groups make it valuable for structural analog research in controlled laboratory settings.

Key identifiers include:

• Synonyms: S-23; (2S)-N-[4-cyano-3-(trifluoromethyl)phenyl]-3-[4-chloro-3-fluorophenoxy]-2-hydroxy-2-methyl-propanamide

• CAS number: 1010396-29-8

• Molecular formula: C18H13ClF4N2O3

• Molecular weight: 416.76 g/mol

These specifications facilitate precise cataloging in laboratory information management systems (LIMS), spectroscopic library matching, and accurate documentation for research protocols and publications.

Chemical & Physical Characteristics

S-23 powder typically appears as a white to off-white crystalline solid, optimized for stability and handling in powdered analytical form. The fine particle size distribution supports accurate gravimetric dispensing, dissolution, and preparation of stock solutions or calibration standards under inert laboratory conditions.

Solubility characteristics include high compatibility with polar aprotic solvents like DMSO (≥20 mg/mL), DMF, and ethanol, with moderate solubility in aqueous buffers when cosolvent systems are employed. Limited water solubility aligns with its lipophilic profile, necessitating empirical solubility testing for specific assay conditions. Thermal stability permits room-temperature manipulations, though characterization of hygroscopicity and polymorphism is recommended for long-term storage planning. Researchers should document batch-specific physical properties to ensure method reproducibility across experiments.

Purity & Analytical Verification

Guaranteed ≥98% purity through multi-method verification including reverse-phase high-performance liquid chromatography (HPLC), chiral HPLC for enantiomeric excess, liquid chromatography-mass spectrometry (LC-MS), and proton nuclear magnetic resonance (1H-NMR) spectroscopy. These orthogonal techniques confirm chemical identity, quantify isomeric purity, profile organic impurities, and detect residual solvents to research-grade specifications. UV absorbance (εmax ~280 nm) provides additional quantification orthogonal to mass-based methods.

Batch-specific COAs detail peak purity ratios (>99% main peak area), mass spectral fragmentation patterns matching reference libraries, and NMR integration values confirming structural integrity. Availability of these documents supports in-house method validation, proficiency testing, and accreditation requirements for analytical laboratories. Third-party retesting services can be engaged for independent confirmation in collaborative or high-stakes research programs. Integration with electronic laboratory notebooks (ELNs) streamlines data management from receipt through experimental execution.

Quality Control & Batch Integrity

Manufacturing follows stringent batch-controlled protocols with unique alphanumeric lot numbering etched on primary containers and mirrored across all documentation for end-to-end traceability. Release criteria encompass incoming raw material CoAs, in-process controls for reaction completion and intermediate isolation, final API characterization, and accelerated stability testing simulating distribution conditions.​

Internal quality unit independence ensures unbiased release decisions, with statistical process control (SPC) monitoring key quality attributes like polymorphic form and particle size distribution. Retained reference standards per lot enable bridge-testing across production campaigns, critical for longitudinal studies spanning multiple years. Optional pharmacopeial-grade testing against USP/EP monographs for related substances further bolsters documentation suitability for grant applications or technology transfer scenarios. This comprehensive framework minimizes supply chain risks while maximizing experimental confidence for institutional purchasers.

Safety, Handling & Laboratory Precautions

Manipulation of S-23 powder demands certified chemical fume hoods or gloveboxes operated by personnel trained in potent compound handling to preclude aerosol generation or dermal transfer. Mandatory PPE comprises double-layered nitrile gloves, chemical splash goggles, disposable lab coats with closed toes, and powered air-purifying respirators (PAPRs) for dusty operations exceeding action levels. Engineering controls like high-efficiency particulate air (HEPA) filtration and negative pressure enclosures form the primary containment barrier.​

Pre-use consultation of the Safety Data Sheet (SDS) delineates GHS hazard pictograms, precautionary statements, physical/chemical hazards (flammability, reactivity), and environmental release prevention strategies. Spill response protocols integrate absorbent neutralization followed by HEPA vacuuming, with decontamination using 70% isopropanol wipes. Waste classification adheres to RCRA hazardous waste regulations; no occupational exposure limits, toxicological reference doses, or medical surveillance recommendations are provided or implied. Institutional chemical hygiene plans govern all deviations from standard operating procedures.

Packaging, Labeling & Storage

Primary containment utilizes amber borosilicate glass vials with PTFE-faced silicone septa and crimped aluminum seals, providing multi-layered protection against hydrolytic degradation, photolytic cleavage, and oxidative side-chain reactions. Secondary overpack employs desiccated HDPE tubs with tamper-evident induction seals for bulk transport resilience. Labeling complies with GHS/CLP standards, featuring product identifier, UN number (if applicable), hazard statements, supplemental EUH warnings, and QR-coded lot lookup for instant digital COA access.​

Recommended storage at -20°C under anhydrous argon headspace preserves chiral integrity and prevents epimerization over multi-year horizons. Photoprotective secondary wrapping mitigates singlet oxygen sensitization pathways. Real-time stability monitoring via differential scanning calorimetry (DSC) informs requalification schedules; excursions to ambient conditions require stability-indicating reassay prior to use. Segregate from incompatibles including strong Lewis acids, hypochlorite bleaches, and metal reductants to preclude exothermic decompositions.

Intended Research Use & Market Positioning

S-23 powder supports advanced applications in androgen receptor pharmacophore modeling, allosteric modulator screening cascades, tissue-selective ligand SAR optimization, and quantitative bioanalytical LC-MS/MS method validation across preclinical discovery pipelines. High potency enables sub-micromolar calibration ranges in fluorescence polarization binding displacement assays and surface plasmon resonance (SPR) kinetic profiling of receptor-ligand complexes.

Positioned exclusively as an analytical reference material, it carries zero designation for in vivo models, human subject research, veterinary formulations, diagnostic reagents, or therapeutic candidates. For research use only. Not for human or veterinary use. Not for clinical, diagnostic, or consumptive applications.

Ordering, Availability & Fulfillment

Immediate availability through validated eCommerce platform with tiered pricing for single-gram through kilogram scales, supporting academic, CRO, and biotech procurement workflows. Checkout integrates PCI-DSS Level 1 compliant gateways, electronic signatures for controlled substance declarations, and automated export control screening. Fulfillment dispatches within 24 business hours via temperature-controlled carriers with end-to-end chain-of-custody documentation and real-time GPS tracking.​

Value-added services encompass custom aliquoting into autosampler-ready matrices, 13C-isotopologue pairing for MRM transitions, sterile filtration into amber autosampler vials, and scheduled replenishment programs keyed to consumption forecasts. Technical account managers provide non-regulatory guidance on solubilization protocols, counterion selection for salt screening, and orthogonal analytical recommendations. Priority allocation reserves freshest lots for standing orders, minimizing potency variance across campaign-spanning experiments.

Legal & Regulatory Disclaimer

S-23 powder qualifies solely as a research chemical absent any FDA/EMA approvals, GRAS status, food additive petitions, or IND-enabling toxicology packages. No representations exist regarding current Good Manufacturing Practice (cGMP) compliance, clinical grade sterility assurance levels (SAL 10^-6), or pharmaceutical excipient compatibility. Acquirers affirm institutional authority, end-use legitimacy, and full jurisdictional compliance encompassing DEA scheduling, EU REACH registrations, and customs import authorizations as applicable.

For research use only. Not for human or veterinary use. Not for clinical, diagnostic, or consumptive applications.