Product Overview

MK-677 Ibutamoren Capsules offer a premium, brandless research chemical precisely formulated for demanding laboratory applications in analytical chemistry, endocrinology research, and synthetic receptor modulator studies. Provided at ≥98% purity (CAS 159634-47-6 for base), these capsules contain the non-peptidic ghrelin receptor agonist in stable salt form, ideal for controlled in vitro assays exploring ligand-receptor dynamics. Qualified researchers in academic, pharmaceutical R&D, and forensic labs utilize this compound for chromatographic standards and structure confirmation protocols.

Unbranded for international research compliance, MK-677 Ibutamoren Capsules ensure consistent fill weights and solubility in standard lab solvents like DMSO or methanol. The encapsulated delivery supports accurate dispensing in microplate-based assays and quantitative spectroscopy. This reagent advances investigations into small-molecule secretagogue analogs within strictly professional settings. For research use only. Not for human or veterinary use. Not for clinical, diagnostic, or consumptive applications.

Each order includes access to detailed Certificates of Analysis (COAs), supporting rigorous documentation needs.

Chemical Identity & Classification

MK-677 Ibutamoren Capsules encapsulate 2-amino-2-methyl-N-[(2R)-1-(1-methylsulfonylspiro[indole-3,4′-piperidine]-1′-yl)-1-oxo-3-phenylmethoxypropan-2-yl]propanamide mesylate (CAS 159752-10-0), with the freebase molecular formula C27H36N4O5S (MW 528.67 g/mol) and mesylate salt at 624.8 g/mol. Synonyms include Ibutamoren mesylate, MK-0677, L-163,191, and Veru-076.

Classified as a reference analytical reagent, it belongs to the spiroindoline-piperidine class of growth hormone secretagogues, featuring sulfonamide, benzyloxypropanamide, and gem-dimethyl motifs. The mesylate salt enhances crystallinity for HPLC standards and LC-MS calibration in non-biological research.

Chemical & Physical Characteristics

The capsule contents appear as a white to off-white crystalline powder, characteristic of high-purity mesylate salts. Low hygroscopicity and uniform particle size facilitate precise volumetric preparations, with bulk density optimized for encapsulation consistency. Solubility is excellent in DMSO (>50 mg/mL), good in methanol and acetonitrile, and moderate in aqueous buffers at pH 7.

Stability persists under ambient conditions when protected from light; the mesylate form resists hydrolysis better than hydrochloride analogs. Melting point ranges 90-100°C (DSC), supporting thermal analytical methods without decomposition.

Purity & Analytical Verification

Batches consistently achieve ≥98% purity via HPLC-UV (220 nm), LC-MS (m/z 529 [M+H]+), and quantitative NMR confirming spiroindoline and sulfonyl protons. Impurity profiles via GC-FID limit related substances to <0.5%, with heavy metals <10 ppm by ICP-MS. Residual solvents meet USP <467> (e.g., <3000 ppm DMSO).

COAs provide full method details, chromatograms, and spectra for independent verification.

Quality Control & Batch Integrity

Lot-controlled synthesis traces from chiral intermediates through mesylate formation, with in-process HPLC, chiral purity checks (>98% R-enantiomer), and FTIR identity confirmation. Third-party ISO 17025 labs validate final release, with retention samples archived for 5 years. Accelerated stability (40°C/75% RH) confirms >95% retention after 24 months.

This ensures capsule content uniformity (RSD <2%) for reproducible research data.

Safety, Handling & Laboratory Precautions

Handle in fume hoods by trained personnel using nitrile gloves, safety glasses, lab coats, and particulate respirators. Minimize dust via antistatic spatulas; use glove boxes for weighing. SDS outlines GHS Category 2 irritant hazards and engineering controls.

Follow lab-specific waste disposal for halogenated organics.

Packaging, Labeling & Storage

Capsules arrive in sealed HDPE bottles with desiccants, child-resistant closures, and labels citing CAS 159752-10-0, lot, purity, GHS icons, and research-only statements per IATA/DOT. Store at 15-25°C, low humidity, dark; refrigerated extension viable >36 months.

Intended Research Use & Market Positioning

Designed for analytical method development, receptor affinity assays, and impurity profiling in pharma QC, academic synthetic chemistry, and toxicology labs. Supports LC/MS library expansion and enantioselective chromatography training. Meets needs of precision-focused research sectors.

Ordering, Availability & Fulfillment

Readily available through compliant WooCommerce platform with secure payments and inventory sync. Orders ship within 24 hours via tracked discreet carriers; COA digital delivery instant. Dedicated support for batch/shipping queries.

Legal & Regulatory Disclaimer

This product is sold strictly for research purposes only. Not for human or veterinary use. Not for clinical, diagnostic, or consumptive applications. Buyers bear responsibility for all jurisdictional compliance; seller provides no use warranties or accepts misuse liability. Confirm regulations before purchase.