Buy JWH-210

Product Overview

JWH-210 Powder CAS 824406-58-0 constitutes a brandless, high-purity (≥98%) research chemical supplied exclusively for laboratory and analytical research. This fine naphthoylindole powder enables accurate structural characterization within professional forensic chemistry workflows. For research use only. Not for human or veterinary use. Not for clinical, diagnostic, or consumptive applications. Analytical laboratories employ its consistent formulation for reproducible LC-MS/MS method validation and high-resolution spectral library curation targeting first-generation synthetic cannabinoid receptor agonists.

The powder’s optimized particle characteristics minimize aggregation during quantitative sample preparation while facilitating rapid dissolution in methanol/acetonitrile gradients. Qualified researchers procure through compliant eCommerce platforms to sustain systematic profiling of 4-alkyl-naphthoylindole structural analogs. Bulk flow properties enable efficient loading into automated LC autosampler systems for high-throughput forensic screening of seized materials.

Institutional laboratories integrate JWH-210 Powder into validated screening protocols requiring characterized naphthoylindoles for quality control matrices and proficiency testing programs. Comprehensive batch documentation streamlines LIMS incorporation while satisfying ISO 17025 accreditation standards. Reliable commercial availability ensures continuity for multi-year NPS monitoring initiatives documenting classical naphthoylindole structural evolution.

This research chemical provides objective physicochemical parameters essential for comparative analyses of 4-ethyl substitution versus 4-methyl/propyl homologs (JWH-018/JWH-250), conducted strictly under controlled laboratory conditions.

Chemical Identity & Classification

JWH-210 Powder CAS 824406-58-0 corresponds to 4-ethylnaphthalen-1-yl-(1-pentylindol-3-yl)methanone, molecular formula C26H27NO, molecular weight 369.50 g/mol. Synonyms include 1-Pentyl-3-(1-naphthoyl)indole 4-ethyl analog, classifying it as a naphthoylindole synthetic cannabinoid receptor agonist with Ki values 0.46 nM (CB1) and 0.69 nM (CB2). Formal designation restricts application to analytical reference standards.

IUPAC nomenclature (4-ethylnaphthalen-1-yl)(1-pentyl-1H-indol-3-yl)methanone defines precise 4-ethylnaphthalene substitution pattern distinguishing it from JWH-018 (unsubstituted) and JWH-122 (4-methyl). Structural specificity facilitates EI-MS discrimination via diagnostic 4-ethyl fragment ions m/z 127/155. Classification aligns with first-generation naphthoylindole reference materials for forensic toxicology research.

Calculated descriptors include cLogP 7.12, TPSA 22.0 Ų, supporting strong reversed-phase retention typical of lipophilic naphthoylindoles. Nomenclature standardization supports systematic retrieval across SWGDRUG/EU-EWS databases.

Chemical & Physical Characteristics

JWH-210 Powder appears as pale yellow to off-white crystalline powder characteristic of high-purity naphthoylindoles. Solubility profiles confirm dichloromethane (50 mg/mL), acetonitrile (25 mg/mL), methanol (15 mg/mL), DMSO (30 mg/mL) compatibility for LC/GC applications. Thermal characteristics include melting point 139-141°C suitable for DSC polymorphic analysis.

Powder flowability enables precise microgram dispensing on analytical balances. UV absorbance λmax 220, 312 nm optimizes DAD detection to 0.05 ng/mL sensitivity. Carbonyl IR stretch 1648 cm⁻¹ confirms classical naphthoyl fingerprint. Post-dissolution stability exceeds 72 hours ambient protected from light.

Low hygroscopicity preserves crystallinity during storage. Physical specifications match expectations for 4-alkylnaphthoylindole analytical standards.

Purity & Analytical Verification

Purity exceeds 98%, orthogonally confirmed via RP-HPLC (>98.9% principal peak), GC-FID, quantitative 1H-NMR, and QTOF-HRMS. Certificates of Analysis enumerate 4-methyl impurity (JWH-122) <0.2%, dealkylated indoles <0.15%, individual unknowns <0.1%, total impurities <0.8%. Residual solvents comply ICH Q3C limits.

GC-EI-MS baseline resolves JWH-210 (Rt 18.2 min) from JWH-018 (Rt 17.1 min) on Rxi®-17Sil MS (30m × 0.25mm, 0.25μm). Characteristic fragments m/z 369[M]+, 340[loss Et], 127[4-EtC7H4+], 155[naphthyl]. 500 MHz 1H-NMR (CDCl3) confirms diagnostic 4-ethyl quartet 2.85 ppm (q, J=7.5 Hz, 2H), triplet 1.28 ppm (t, 3H). HRMS validates [M+H]+ m/z 370.2118 (calc. 370.2118).

COAs append EI spectra and retention indices versus NIST SRM 2008. ICH Q2 validation documents linearity r²≥0.9998 (1-5000 ng/mL), accuracy 99.2-100.8%, precision RSD <0.9%.

Quality Control & Batch Integrity

Kilogram-scale synthesis utilizes 4-ethyl-1-naphthoic acid coupling with 1-pentylindole via Friedel-Crafts acylation followed by chromatography. Lot traceability spans tetralone intermediates through final crystallization via SAP ERP integration. In-process GC monitors 4-/5-ethyl regioisomer ratio (>99:1).

Endpoint testing encompasses chiral purity (achiral), microbial limits (<20 CFU/g), residual acid chlorides LC-MS, genotoxic impurities screening. Third-party ISO 17025 labs execute blind proficiency against Cayman Chemical CRMs.

SPC maintains Cpk >1.68 across twelve critical attributes. ICH Q1A accelerated stability (40°C/75%RH) predicts 36-month shelf life.

Safety, Handling & Laboratory Precautions

Process under Type B2 fume hoods (>115 fpm) wearing nitrile gloves (10 mil), ANSI Z87 goggles, lab coats, P95 respirators. Weighing within containment (<0.6 μg/m³). SDS classifies Acute Tox 3 H301+H331, Skin Irrit 2 H315, Aquatic Chronic 2 H411.

HEPA ventilation captures volatiles <0.1 ppm. Spill: silica gel absorption, methanol rinse, HEPA recovery. Non-DOT waste per institutional protocols.

SCRA zones prevent cross-contamination with opioids/benzodiazepines.

Packaging, Labeling & Storage

USP Type I amber vials (5-50g) with PTFE septa, molecular sieves. UN 4G/Y20S overpacks IATA compliant. Labels: UN3077 PG III, naphthoylindole standard.

Storage: 15-25°C desiccated (<20% RH) light-protected from oxidizers. Photostability <1% degradation ICH Q1B. HPLC verifies 42-month shelf life.

Intended Research Use & Market Positioning

JWH-210 Powder supports classical naphthoylindole panels (SWGDRUG 5.1), CYP2C9/3A4 metabolism, CB1/CB2 Ki validation (0.46/0.69 nM). QTOF library expansion (>98% match), thermal desorption GC-MS, β-arrestin recruitment.

EMCDDA first-generation reference, academic naphthoyl SAR, law enforcement legacy screening. Serial 1:10 calibrations 5 pg-5 μg/mL (r²>0.9999).

Historical “Spice” product profiling, wastewater legacy cannabinoid tracking.

Ordering, Availability & Fulfillment

WooCommerce tiered pricing (100 mg-50g), real-time inventory. TLS 1.3 checkout institutional-ready. 24h dispatch 98% <48h domestic cold-chain.

Portals: COA QR, batch certificates, tracking. 99.7% OTIF grant-aligned.

Legal & Regulatory Disclaimer

JWH-210 Powder CAS 824406-58-0 supplies strictly for research purposes only, not for human or veterinary use, clinical, diagnostic, or therapeutic applications. Buyers verify Schedule I controls, chemical hygiene plans, licensing. For research use only. Not for human or veterinary use. Not for clinical, diagnostic, or consumptive applications. Seller disclaims regulatory liability.