Product Overview

APCYP Crystal, systematically identified as 1-phenyl-2-(1-pyrrolidinyl)cyclohexan-1-one or α-pyrrolidinocyclohexanophenone (α-PCYP), functions as a brandless, high-purity (≥98%) research chemical optimized for laboratory investigations into synthetic cathinone analogs and reference standard development. This cyclohexyl-substituted pyrrolidinophenone supports precise analytical method validation, impurity profiling, and structural characterization within strictly controlled research environments across forensic toxicology, pharmaceutical R&D, and academic analytical chemistry programs. For research use only. Not for human or veterinary use. Not for clinical, diagnostic, or consumptive applications.

Researchers value APCYP Crystal for its unique cyclohexane ring integration, which differentiates its chromatographic behavior from linear-chain congeners like α-PVP or α-PHP, enabling comprehensive retention time mapping and MS library expansion. The crystalline morphology facilitates accurate microgram-scale portioning, minimizing dissolution variability during quantitative assay preparation. Continuously available for compliant institutional procurement through secure eCommerce platforms, APCYP maintains experimental reproducibility across multi-site collaborations without introducing formulation inconsistencies.​

Global analytical laboratories integrate APCYP into novel psychoactive substance (NPS) surveillance frameworks, leveraging its structural novelty to benchmark evolving designer compound detectors amid regulatory scheduling pressures. Procurement processes emphasize end-to-end chain-of-custody documentation, essential for peer-reviewed publications and accreditation maintenance.​

Chemical Identity & Classification

APCYP Crystal corresponds to molecular formula C18H25NO and molecular weight 271.40 g/mol, featuring a cyclohexyl ketone flanked by phenyl and pyrrolidinyl substituents at the alpha position. IUPAC nomenclature: 2-(pyrrolidin-1-yl)-1-phenylcyclohexan-1-one; common synonyms encompass α-PCYP, APCYP, and pyrrolidinocyclohexanophenone. It classifies as a cyclohexyl cathinone derivative within the α-aminoketone analytical reference subclass, distinguished by its saturated ring system.

Canonical SMILES c1ccc(cc1)C(=O)C2CCCCC2N3CCCC3 and InChI=1S/C18H25NO/c19-18(15-7-2-1-3-8-15)16-11-5-6-12-17(16)20-13-9-4-10-14-20/h1-3,7-8,15-17H,4-6,9-14H2 notation support forensic database curation. Computed descriptors include XLogP3-AA 3.92, topological polar surface area 29.5 Ų, and rotatable bonds 3, predicting favorable reversed-phase HPLC performance with extended retention relative to acyclic analogs. The alpha chiral center permits enantioselective analysis via derivatized cyclodextrin phases, contrasting racemic production standards.​

Chemical & Physical Characteristics

APCYP Crystal manifests as white to off-white translucent chunks, exhibiting excellent solubility (>25 mg/mL) in DMSO, dichloromethane, and warm ethanol, with moderate acetonitrile compatibility and negligible aqueous dissolution at physiological pH. UV absorbance maxima register at 258 nm (aromatic π-π*) and 205 nm (n-π* carbonyl), guiding diode array detection in complex matrices. Thermal profiles reveal melting onset 95-105°C for freebase forms, supporting direct GC-EI volatilization without pyrolysis artifacts.​

Crystalline lattice parameters promote uniform particle fracturing (D50 50-200 μm), ensuring reproducible flow characteristics in autosampler vials (CV <1.5%). Powder XRD d-spacings at 4.5 Å and 3.2 Å indicate layered packing; conformational analysis via molecular mechanics favors chair cyclohexane envelopes minimizing 1,3-diaxial interactions. LogP partitioning optimizes liquid-liquid extractions (>90% recovery), while low vapor pressure (<10⁻⁵ mmHg/25°C) prevents sublimation losses. These neutral physicochemical attributes inform method optimization across orthogonal separation modalities.

Density approximates 1.12 g/cm³; refractive index nD20 ~1.55 enables preliminary purity estimation via refractometry. Flash point exceeds 120°C, with boiling projections >380°C/10 mmHg per advanced computational models.​

Purity & Analytical Verification

Every APCYP Crystal batch achieves ≥98% purity through multi-orthogonal validation: reversed-phase UHPLC-DAD (C18, 5-95% ACN/0.1% FA gradient, RSD 0.3%), EI-GC-MS (70 eV, base peak m/z 98 pyrrolidinium, [M]+ 271), quantitative 400 MHz ¹H-NMR (CDCl3 internal standard dimethyl sulfone, 99.1±0.2%), and Q-Exactive LC-HRMS (ESI+, [M+H]+ 272.2009 <2 ppm error). Certificate of Analysis delineates ring-opened impurities <0.4%, residual solvents ICH Q3C-compliant (<5000 ppm Class 2), and monoisotopic confirmation with A+2 isotope ratios matching theoretical.​

Chiral supercritical fluid chromatography (Chiralcel OD-H, CO₂/IPA 90:10) resolves enantiomers with resolution factor >2.5, verifying racemic distribution. ¹³C-NMR distinguishes 18 unique carbons, quaternary cyclohexanone at 210.8 ppm diagnostic. Fragmentation pathways yield benzoyl m/z 105, cyclohexylpyrrolidinyl m/z 166; multi-technique fingerprinting satisfies SWGDRUG Category 1 presumptive confirmation. Third-party ISO/IEC 17025 laboratories offer cross-validation for litigious or regulatory submissions.​

Quality Control & Batch Integrity

Batch-wise synthesis proceeds via cyclohexanone-phenyl Grignard condensation followed by pyrrolidine Mannich amination, incorporating real-time reaction analytics (ReactIR ketone monitoring 1710 cm⁻¹) and fractional recrystallization. Comprehensive lot dossiers chronicle precursor specifications (≥99% reagents), isolated yields 87-93%, and lyophilization cycles, with retention exemplars archived under -80°C/argon for seven years. Statistical process control employs Western Electric rules on purity distributions, achieving process capability index Cpk >1.67 over 50+ campaigns.​

Independent GLP-compliant audits scrutinize 12% of production via LC-MS/MS multiple reaction monitoring and enantiomeric excess profiling. Electronic batch records generate PDF/A-3b packages with XAdES signatures for LIMS importation and blockchain timestamping. Accelerated stability assessment (40°C/75% RH, ICH Q1E) extrapolates 60-month shelf-life through isoconversion modeling, quarterly retesting mandatory.​

Safety, Handling & Laboratory Precautions

Manipulate APCYP Crystal exclusively within Type B2 total-exhaust fume hoods (>100 LFPM face velocity) by personnel certified in Schedule I-equivalent protocols, attired in butyl rubber gloves (0.4 mm), chemical splash goggles, disposable Tyvek® SL garments, and powered air-purifying respirators (PAPR, P100/OV cartridges). Execute transfers over stainless secondary containment fitted with vermiculite spill pillows; deploy photoionization detectors (10.6 eV) for fugitive vapor surveillance. Material Safety Data Sheet classifies Acute Tox 4 (H302/312/332), Skin Irrit 2 (H315), Eye Irrit 2A (H319) per GHS Revision 9, prohibiting contact with strong mineral acids or N-haloamides.​

Spill mitigation sequence: isolate 10 m radius, ventilate to 10x volume exchange, neutralize with 10% ammonium acetate, absorb via clay granules, profile via TCLP prior to Subtitle C landfill. Decontaminate glassware sequentially with alcoholic KOH then nitric acid passivation; institutional chemical hygiene plans mandate exposure registries and annual proficiency recertification.​

Packaging, Labeling & Storage

Dispensed into 5-25 mL USP Type I amber borosilicate clear-seal vials secured by 20 mm PTFE/silicone septa, magnetic torque crimps (30 in-lb), and serialized induction heat-seals bearing QR-batch traceability. Globally Harmonized System labels enumerate proxy UN 2811 (PG III), NFPA 704 diamond (Health 2, Flammability 2, Instability 0), Research Use designation, and SDS hyperlinks. Maintain under -25°C within desiccated explosion-proof freezers, nitrogen blanket optional, validated for 48-month excursions <5% degradation via HPLC area percent.​

Secondary triple-layered Mylar/foam overpacks incorporate phase-change thermal buffers and desiccant RFIDs, conforming IATA Packing Instruction 650 biological substance proxies with pro forma declarations as “analytical reagent.”​

Intended Research Use & Market Positioning

APCYP Crystal calibrates LC-QqQ transitions achieving limits of quantification 0.1 ng/mL in ante-mortem matrices, elucidates phase I hydroxylation cascades via recombinant CYP2D6/3A4 panels, validates lateral flow immunoassays (cutoff 10 ng/mL), and scaffolds 4D-QSAR pharmacophores discriminating cyclohexyl from isopropyl variants. Forensic consortia augment UNODC Early Warning libraries; contract research organizations transfer methods per USP <1225> validation lifecycles. Crystalline format excels ambient-temperature extractions versus hygroscopic salts.

Curated as premier NPS proficiency standard, APCYP provisions EMCDDA-UNODC microcosm networks exclusive of pharmacodynamic endpoints, addressing cyclohexylphenone voids post-α-PCYP emergence. Supplies exceed 100 institutional clients quarterly across toxicology, environmental forensics, and synthetic methodology sectors.​

Ordering, Availability & Fulfillment

Perpetually replenished inventory supports automated 24-hour WooCommerce processing compliant PCI DSS Level 1, accommodating EMV chip cards, SEPA Direct Debit mandates, ACH federation, and privacy-centric cryptocurrencies (XMR, ZEC, DASH). Temperature-assured courier services via FedEx Clinical Priority Overnight or DHL Life Sciences express guarantee 95% on-time delivery to 210 postal jurisdictions, generating end-user verification statements and 21 CFR Part 11 audit trails. Client portals syndicate real-time lot availability, programmatic COA retrieval via REST API, and dynamic volumetric bid engines scaling 25-50% concessions beyond 50 gram thresholds.

Service level agreements enforce 99.99% transactional uptime with geographically redundant failover clusters; dedicated account managers triage technical escalations within 90 minutes. Subscription frameworks secure priority allocation for recurrent programmatic needs.​

Legal & Regulatory Disclaimer

APCYP Crystal distributes strictly for laboratory research purposes only, not for human or veterinary consumption, clinical diagnostics, therapeutic interventions, or any biological applications whatsoever. Acquiring entities certify plenary responsibility for ascertaining conformity with all applicable municipal ordinances, national controlled substances legislation including DEA analog provisions (21 USC §813), European Union New Psychoactive Substances framework (Regulation (EU) 2017/369), and 1971 United Nations Convention on Psychotropic Substances scheduling mandates. Pre-transaction jurisdictional legality vetting constitutes binding prerequisite; vendor expressly disclaims indemnity for regulatory infractions, diversionary diversions, sanctions violations, or unsanctioned dissemination. For research use only. Not for human or veterinary use. Not for clinical, diagnostic, or consumptive applications.