Buy 7-ADD

Product Overview

7-ADD Powder constitutes a brandless, high-purity (≥98%) research chemical supplied exclusively for laboratory and analytical research. This fine synthetic cannabinoid powder supports accurate structural characterization within professional forensic chemistry workflows. For research use only. Not for human or veterinary use. Not for clinical, diagnostic, or consumptive applications. Analytical laboratories employ its consistent formulation for reproducible LC-MS/MS method validation and high-resolution spectral library curation targeting advanced indole carboxamide derivatives.

The powder’s optimized particle characteristics minimize aggregation during quantitative sample preparation while facilitating rapid dissolution in standard LC mobile phases. Qualified researchers procure through compliant eCommerce channels to maintain supply continuity for systematic profiling of alkylated synthetic cannabinoid receptor agonist analogs. Flow properties enable efficient loading into automated sampling systems for high-throughput quantitative analysis of seized forensic materials.

Institutional laboratories integrate 7-ADD Powder into validated screening protocols requiring characterized synthetic cannabinoids for quality control matrices and proficiency testing programs. Comprehensive batch documentation streamlines LIMS incorporation while meeting ISO 17025 accreditation standards. Reliable commercial availability ensures continuity for multi-year NPS monitoring initiatives tracking structural evolution within carboxamide subclasses.

This research chemical delivers objective physicochemical parameters essential for comparative analyses of novel alkyl substitution patterns versus classical JWH frameworks, conducted strictly under controlled laboratory conditions.

Chemical Identity & Classification

7-ADD Powder corresponds to N-(1-amino-3,3-dimethyl-1-oxobutan-2-yl)-1-(5-fluoropentyl)-1H-indole-3-carboxamide with molecular formula C20H28FN3O2 and molecular weight 361.46 g/mol. Synonyms include 7-ADD and 5F-MDMB-PICA, classifying it as a synthetic cannabinoid receptor agonist featuring indole-3-carboxamide scaffold coupled to tert-leucylamide pharmacophore with omega-fluorinated pentyl chain. Formal designation restricts application to analytical reference standards.

IUPAC nomenclature defines precise fluorine positioning at pentyl C5′ and amide stereochemistry, enabling definitive LC-HRMS identification from parent MDMB-PICA scaffold. Structural specificity facilitates discrimination from 4F/6F positional isomers during tandem MS fragmentation comparisons. Classification aligns with fluorinated indole carboxamide subclass materials for forensic toxicology research.

Calculated descriptors include cLogP 3.2, TPSA 86.2 Ų, supporting retention prediction across C18, pentafluorophenyl, and HILIC stationary phases. Systematic nomenclature supports retrieval across international NPS databases.

Chemical & Physical Characteristics

7-ADD Powder appears as white to off-white crystalline powder characteristic of fluorinated indole carboxamides. Solubility profiles confirm methanol (14 mg/mL), acetonitrile (11 mg/mL), DMSO (18 mg/mL), and 0.1% formic acid (7 mg/mL) compatibility for LC gradient elution. Thermal decomposition onset >245°C suitable for LC-MS analysis.

Powder flowability supports precise microgram dispensing using analytical balances. UV absorbance λmax 224, 290 nm enables sub-ng/mL detection limits with DAD monitoring. Amide pKa ~9.6 produces stable [M+H]+ ions in positive ESI. Solution stability exceeds 48 hours ambient protected from light.

Low hygroscopicity (<4% w/w at 60% RH) maintains crystalline lattice during storage. Physical specifications match expectations for omega-fluorinated SCRA analytical standards.

Purity & Analytical Verification

Purity exceeds 98%, orthogonally validated via RP-HPLC (>98.6% principal peak), GC-EI-MS, quantitative 19F-NMR, and Orbitrap HRMS. Certificates of Analysis enumerate desfluoro impurities <0.15%, amide hydrolysis products <0.1%, individual unknowns <0.13%, total impurities <0.85%. Residual solvents satisfy ICH Q3C limits.

LC utilizes Kinetex C18 (100×2.1 mm, 1.7 μm) with 10 mM ammonium formate/MeCN gradient, resolving 7-ADD from 4F/6F isomers (Rs >2.9). 400 MHz 1H-NMR (DMSO-d6) confirms diagnostic signals: 8.12 ppm (s, H-2 indole), 4.52 ppm (dd, H-2′), 1.08 ppm (s, 9H tBu). 19F-NMR verifies -215.8 ppm (t, J=27 Hz, ω-F). HRMS confirms [M+H]+ m/z 362.2243 (calc. 362.2243, Δ<1 ppm).

COAs include extracted ion chromatograms and MS/MS spectra versus certified references. ICH Q2 validation confirms linearity r²≥0.9996 (0.3-1800 ng/mL), accuracy 99.1-101.0%, precision RSD <1.0%.

Quality Control & Batch Integrity

Batch synthesis employs regioselective indole-3-carbonyl chloride coupling with N-Boc-tert-leucylamine followed by 5-fluoropentyl bromide alkylation and recrystallization. Lot traceability spans raw materials through final milling via validated ERP systems. In-process LC monitors regioselectivity (>99:1 N1-alkylation).

Endpoint qualification includes chiral HPLC (racemic), microbial limits (<10 CFU/g), genotoxic impurities LC-MS/MS (350+ compounds), heavy metals (<3 ppm F-corrected). Third-party ISO 17025 labs execute blind verification against CRMs.

SPC maintains Cpk >1.62 across critical quality attributes. ICH Q1A stability confirms 30-month predictions.

Safety, Handling & Laboratory Precautions

Process under Type B2 fume hoods (>120 fpm) wearing butyl gloves (0.4 mm), face shields, chemical-resistant coveralls, P100 respirators. Weigh within containment isolators (<0.4 μg/m³). SDS classifies Acute Tox 3 H301+H331, Skin Corr. 1B H314.

HEPA ventilation captures volatiles <0.1 ppm. Spill protocol: inert absorbents, alkaline neutralization, HEPA recovery. Waste as P-listed hazardous requiring TSDF disposal.

SCRA handling zones prevent cross-contamination with opioids/benzodiazepines.

Packaging, Labeling & Storage

USP Type I amber vials (5-25g) with PTFE septa, 4Å sieves. UN 4G/Y18S overpacks comply IATA DGR. Labels: UN3077 PG III, fluorinated organic reference.

Storage: -20°C desiccated (<10% RH) from oxidizers/acids. Photostability <0.7% degradation (ICH Q1B). HPLC confirms 36-month shelf life.

Intended Research Use & Market Positioning

7-ADD Powder supports forensic NPS panels (SWGDRUG 6.1), CYP3A4/2D6 metabolism mapping, CB1/CB2 Ki profiling. Enables QTOF library expansion (>96% match), polymorph XRD, β-arrestin assays.

EMCDDA Early Warning reference, academic SCRA SAR research, law enforcement validation. Serial 1:15 calibrations 15 pg-1.5 μg/mL (r²>0.9999).

Wastewater SCRA epidemiology, hepatocyte clearance modeling.

Ordering, Availability & Fulfillment

WooCommerce tiered pricing (250 mg-25g), TLS 1.3 checkout. 24-hour dispatch 98% <72h global cold-chain. Portals: COA QR, batch records, GPS tracking. 99.5% OTIF.

Legal & Regulatory Disclaimer

7-ADD Powder supplies strictly for research purposes only, not for human or veterinary use, clinical, diagnostic, or therapeutic applications. Buyers verify NPS controls, chemical hygiene, licensing. For research use only. Not for human or veterinary use. Not for clinical, diagnostic, or consumptive applications. Seller disclaims regulatory liability.