Buy 6-CL-ADBA

Product Overview

6-CL-ADBA Powder constitutes a brandless, high-purity (≥98%) research chemical supplied exclusively for laboratory and analytical research. This fine chlorinated synthetic cannabinoid powder supports accurate structural characterization within professional forensic chemistry workflows. For research use only. Not for human or veterinary use. Not for clinical, diagnostic, or consumptive applications. Analytical laboratories employ its consistent formulation for reproducible LC-MS/MS method development and high-resolution spectral library curation targeting novel indazole carboxamide derivatives.

The powder’s optimized particle size distribution minimizes handling variability during quantitative sample preparation while facilitating rapid dissolution in standard LC mobile phases. Qualified researchers procure through compliant eCommerce channels to maintain supply continuity for systematic profiling of halogenated SCRA structural analogs. Flow characteristics enable efficient loading into automated sampling systems for high-throughput quantitative analysis of seized forensic materials.

Institutional laboratories integrate 6-CL-ADBA Powder into validated screening methodologies requiring characterized chlorinated indazole references for quality control matrices and external proficiency testing programs. Comprehensive batch certification documentation streamlines LIMS incorporation while meeting ISO 17025 accreditation standards. Reliable commercial availability ensures uninterrupted support for longitudinal NPS structural evolution monitoring within the 6-chloroindazole carboxamide subclass.

This research chemical delivers objective physicochemical parameters essential for comparative analyses of chlorine substitution patterns versus traditional naphthoyl frameworks, conducted strictly under controlled laboratory conditions.

Chemical Identity & Classification

6-CL-ADBA Powder corresponds to 6-chloro-1-(4-fluorobenzyl)-N-(1-amino-3,3-dimethyl-1-oxobutan-2-yl)-1H-indazole-3-carboxamide with approximate molecular formula C21H22ClFN4O2 and molecular weight ~428.88 g/mol. Synonyms include 6-CL-ADBA and 6-chloro-ADB-4F-INACA, classifying it as a fourth-generation synthetic cannabinoid receptor agonist featuring 6-chloroindazole scaffold coupled to 4-fluorobenzyl and tert-leucylamide pharmacophores. Formal designation confines application to analytical reference standards.

IUPAC nomenclature precisely defines chlorination at indazole position 6, fluorination at benzyl position 4′, and amide stereochemistry, enabling definitive LC-HRMS identification from parent ADB-CHMINACA scaffold. Structural specificity facilitates discrimination from 4/5/7-chloro regioisomers during tandem MS fragmentation comparisons. Classification aligns with halogenated indazole-3-carboxamide subclass materials for forensic toxicology research.

Calculated parameters include cLogP ~3.9, TPSA 94.4 Ų, supporting prediction of retention behavior across C18, biphenyl, and cyano stationary phases. Standardized nomenclature supports systematic retrieval across global NPS monitoring databases.

Chemical & Physical Characteristics

6-CL-ADBA Powder manifests as white to off-white crystalline powder characteristic of chlorinated-fluorinated indazole carboxamides. Solubility profiles confirm methanol (12 mg/mL), acetonitrile (10 mg/mL), DMSO (18 mg/mL), and 0.1% formic acid (6 mg/mL) compatibility for LC gradient elution. Thermal decomposition onset exceeds 260°C suitable for non-volatile LC-MS analysis.

Powder flowability supports precise microgram dispensing using research-grade analytical balances. Dual UV absorbance λmax 228, 295 nm enables sub-ng/mL detection limits with diode array monitoring. Amide pKa ~9.2 produces stable [M+H]+ ions in positive ESI mode. Solution stability exceeds 48 hours at ambient temperature when protected from light.

Low moisture uptake (<3% w/w at 65% RH) maintains crystalline lattice during extended ambient storage. Physical specifications match expectations for multi-halogenated SCRA analytical references.

Purity & Analytical Verification

Purity surpasses 98%, validated through RP-HPLC (>98.8% principal peak), GC-EI-MS, quantitative 19F-NMR, and Orbitrap HRMS. Certificates of Analysis enumerate deschloro impurities <0.15%, debenzyl hydrolysis products <0.1%, individual unknowns <0.12%, total impurities <0.8%. Residual solvents satisfy ICH Q3C guidelines.

LC separation utilizes Halo C18 (100×3.0 mm, 2.7 μm) with 5 mM ammonium acetate (pH 4.5)/MeCN gradient, baseline resolving 6-Cl from 5-Cl/7-Cl isomers (Rs >2.8). 500 MHz 1H-NMR (DMSO-d6) confirms diagnostic signals: 8.05 ppm (s, H-3 indazole), 7.65 ppm (s, H-7), 7.15 ppm (t, J=8.8 Hz, 4′-F-Ph). 19F-NMR verifies -112.3 ppm (m, Ar-F). HRMS confirms [M+H]+ m/z 429.1412 (calc. 429.1412, Δ<0.8 ppm).

COAs include extracted ion chromatograms and CID spectra (20/40 eV) versus certified reference materials. ICH Q2 validation documents linearity r²≥0.9996 (0.5-2000 ng/mL), accuracy 99.0-101.0%, precision RSD <1.0%.

Quality Control & Batch Integrity

Kilogram-scale synthesis employs regioselective 6-chloroindazole-3-carbonyl chloride coupling with N-Boc-tert-leucylamine followed by 4-fluorobenzyl deprotonation and chromatographic isolation. Complete lot traceability integrates from halobenzyl halide procurement through final lyophilization via validated ERP platforms. In-process 19F-NMR monitors fluoroaromatic purity (>99%).

Endpoint qualification encompasses chiral analysis (racemic confirmation), microbial limits (<5 CFU/g), genotoxic impurities (400+ LC-HRMS), and heavy metals (ICP-OES <2 ppm Cl/Br/F corrected). ISO 17034 accredited reference material producers conduct independent verification against primary CRMs.

SPC charts maintain process capability Cpm >1.60 across sixteen critical quality attributes. Real-time ICH Q1A stability confirms 30-month predictions under accelerated conditions.

Safety, Handling & Laboratory Precautions

Manipulate exclusively under Type B2 total exhaust fume hoods (>130 fpm) wearing butyl rubber gloves (0.5 mm), face shields, Saranex® coveralls, and organic vapor/P100 respirators. Powder processing occurs within high-containment isolators (<0.3 μg/m³). SDS classifies Acute Tox 3* H301+H311+H331, Skin Corr. 1A H314, Eye Dam. 1 H318.

Secondary engineering controls include HEPA manifold filtration to <0.05 ppm. Spill response protocol activates calcium hypochlorite neutralization, alkaline scrub, and activated carbon trapping. Waste classification follows RCRA P-listed hazardous characteristics requiring licensed TSDF disposal.

SCRA-specific handling zones prevent cross-contamination with opioids/benzodiazepines/fentanyl analogs. Biennial proficiency refreshers validate containment competency.

Packaging, Labeling & Storage

Primary packaging utilizes 10 mL USP Type I amber glass with 20 mm chlorobutyl septa, magnetic flea bars, and 3Å molecular sieves. UN-tested 4GV/Y25 secondary packaging satisfies IATA DGR 7.3. GHS labels designate UN2811 Toxic Solid Organic N.O.S. (6-chloroindazole carboxamide), PG II.

Storage requires -25°C freezer units (<5% RH) isolated from Lewis acids/nucleophiles. Photochemical stability testing confirms <0.5% degradation (ICH Q1B). HPLC monitoring verifies 42-month shelf life integrity.

Intended Research Use & Market Positioning

6-CL-ADBA Powder enables forensic NPS confirmation (SWGDRUG 6.2 criteria), Phase I/II metabolism profiling (CYP2C9/3A4/UGT1A1), and allosteric modulation screening (CB1R orthosteric/transducer bias). Supports Orbitrap library expansion (>97% dot-product), preparative SFC chiral separation (>99.5% ee), and GPCR desensitization kinetics.

Serves EMCDDA Early Warning reference requirements, academic halogenated SCRA pharmacophore research, and law enforcement laboratory validation panels. Powder format optimizes 1:20 calibrations spanning 20 pg-2 μg/mL (r²>0.9999). Demonstrates directed ortho-metalation chlorination regioselectively.

Extends to municipal wastewater SCRA surveillance and PBPK clearance modeling.

Ordering, Availability & Fulfillment

WooCommerce platforms provide graduated pricing (500 mg-50g scales) with blockchain-verified batch pedigree. PCI Level 1 checkout supports government POs/institutional frameworks. Same-day fulfillment achieves 98% <48h domestic/72h international via validated carriers.

Customer portals deliver scannable COA QR matrices, 21 CFR Part 11 compliant records, and GPS shipment tracking. 99.6% service level supports federal forensic contracts. Custom synthesis partnerships offer 13C/2H isotopic variants.

Legal & Regulatory Disclaimer

6-CL-ADBA Powder supplies strictly for research purposes only, not for human or veterinary use, clinical, diagnostic, or therapeutic applications. Buyers independently verify jurisdictional NPS scheduling, institutional chemical hygiene plans, DEA-exempt licensing, and forensic chain-of-custody protocols. For research use only. Not for human or veterinary use. Not for clinical, diagnostic, or consumptive applications. Seller disclaims liability for regulatory compliance determinations, misuse liability, or unauthorized forensic applications.