Buy 5BR-ADB-INACA Powder

Product Overview

5BR-ADB-INACA Powder serves as a brandless, high-purity (≥98%) research chemical designated exclusively for laboratory and analytical research. This fine synthetic cannabinoid powder enables accurate characterization studies within professional forensic and analytical chemistry workflows. For research use only. Not for human or veterinary use. Not for clinical, diagnostic, or consumptive applications. Research laboratories utilize its consistent formulation for reproducible LC-MS/MS method validation and HRMS library development targeting novel indazole carboxamide structures.

The powder’s optimized particle characteristics minimize aggregation during sample preparation while supporting rapid dissolution in methanol/acetonitrile gradients. Qualified analytical chemists procure through compliant eCommerce platforms to sustain systematic profiling of brominated synthetic cannabinoid receptor agonist (SCRA) analogs. Bulk handling properties facilitate efficient aliquoting into LC autosampler vials for high-throughput screening of seized materials and reference standard certification.

Institutional forensic laboratories integrate 5BR-ADB-INACA Powder into validated screening protocols requiring characterized SCRAs for quality control matrices and proficiency testing programs. Comprehensive batch documentation streamlines incorporation into laboratory information management systems while satisfying ISO 17025 accreditation requirements. Steady commercial availability ensures continuity for multi-year NPS monitoring initiatives tracking structural evolution within indazole-3-carboxamide subclasses.

This research chemical provides neutral structural data essential for comparative analyses of 5-bromo-indazole substitution patterns versus traditional naphthoylindole frameworks, conducted strictly under controlled laboratory conditions.

Chemical Identity & Classification

5BR-ADB-INACA Powder corresponds to N-(1-amino-3,3-dimethyl-1-oxobutan-2-yl)-5-bromo-1H-indazole-3-carboxamide, with molecular formula C14H17BrN4O2 and molecular weight 353.22 g/mol. Synonyms include ADB-5Br-INACA and 5-bromo-ADB-INACA, classifying it as a third-generation synthetic cannabinoid receptor agonist featuring 5-bromoindazole-3-carboxamide scaffold coupled to tert-leucine amide pharmacophore. Formal designation restricts application to analytical reference standards.

IUPAC nomenclature precisely defines bromination at indazole position 5 and amide stereochemistry at C2′, enabling unambiguous LC-HRMS identification from ADB-INACA parent scaffold. This structural specificity facilitates discrimination from 4/6/7-bromo regioisomers during EI-MS fragmentation pattern comparisons. Classification aligns with indazole carboxamide subclass reference materials employed in forensic toxicology and designer drug research.

Calculated physicochemical parameters include cLogP 2.8, TPSA 94.4 Ų, and four H-bond donors, predicting moderate retention across C18/HILIC stationary phases. Synonym standardization supports systematic retrieval across global NPS databases while maintaining research-only classification boundaries.

Chemical & Physical Characteristics

5BR-ADB-INACA Powder appears as white to off-white crystalline powder typical of brominated indazole carboxamides. Solubility profiles confirm methanol (>10 mg/mL), acetonitrile (8 mg/mL), DMSO (15 mg/mL), and 0.1% formic acid (5 mg/mL) compatibility, enabling diverse LC gradient compositions. Thermal stability registers decomposition onset >250°C suitable for non-volatile analyte profiling.

Powder flowability supports quantitative microgram transfers using analytical balances. Principal UV absorbance λmax 225, 292 nm optimizes DAD detection limits to 0.1 ng/mL sensitivity. Amide pKa ~9.5 facilitates positive ESI ionization with abundant [M+H]+ formation. Post-dissolution solutions maintain stability >24 hours at ambient temperature protected from light.

Low hygroscopicity (<5% w/w at 60% RH) preserves lattice integrity during extended storage. Physical specifications systematically match expectations for 5-halogenated indazole-3-carboxamide analytical standards.

Purity & Analytical Verification

Purity exceeds 98%, orthogonally validated via RP-HPLC (>98.5% principal peak), GC-EI-MS, quantitative 1H-NMR, and QTOF-HRMS. Certificates of Analysis enumerate process-related desbromo impurities <0.2%, indazole hydrolysis products <0.1%, individual unknowns <0.15%, total impurities <1.0%. Residual solvents comply with ICH Q3C limits.

LC method employs Kinetex C18 (100×2.1 mm, 1.7 μm) with 10 mM ammonium formate (pH 3.0)/MeCN gradient, resolving 5Br-ADB-INACA from ADB-INACA (Rt Δt=0.45 min, Rs=3.2) and regioisomeric impurities. 400 MHz 1H-NMR (DMSO-d6) confirms diagnostic 7.8 ppm (d, J=2.0 Hz, H-4 indazole), 7.5 ppm (dd, H-6), 1.05 ppm (s, 9H tBu). HRMS validates [M+H]+ m/z 354.0608 (calc. 354.0608, Δ<1 ppm).

COAs append extracted ion chromatograms and MS/MS spectra (CE 20/35/50 eV) versus Cayman Chemical reference standard. ICH Q2 validation confirms linearity r²≥0.9995 (1-1000 ng/mL), accuracy 98.8-101.2% recovery, precision RSD <1.2%.

Quality Control & Batch Integrity

Multi-kilogram batch synthesis utilizes regioselective 5-bromoindazole-3-carbonyl chloride coupling with tert-leucylamide under Schotten-Baumann conditions, followed by recrystallization from IPA/water. Lot traceability spans starting material CoAs through final milling via SAP-integrated ERP systems. In-process HPLC monitors regioselectivity (>98:2 5Br:7Br).

Endpoint release includes chiral HPLC (racemic confirmation), microbial enumeration (<10 CFU/g), heavy metals (<5 ppm Br-corrected), and Genotoxic impurities LC-MS/MS (300+ compounds). Third-party ISO 17025 facilities execute blind duplicate testing against CRM standards.

Statistical process control maintains Cpk >1.67 across twelve critical quality attributes. Real-time stability monitoring under ICH Q1A conditions confirms 24-month predictions.

Safety, Handling & Laboratory Precautions

Process exclusively under Type B2 total exhaust fume hoods (>120 fpm face velocity) wearing Viton gloves (0.4 mm), chemical splash goggles, Tychem® SL garments, and P100 respirators. Conduct weighings within containment isolators maintaining <0.5 μg/m³ airborne challenge. SDS classifies Acute Tox 3 H301+H311+H331, Skin Corr. 1B H314.

HEPA-filtered glovebags contain aerosol generation during powder transfers. Spill contingencies employ soda ash neutralization followed by 10% NaHCO3 scrub and sticky-mat decon. Waste manifests as P-listed U002 characteristic hazardous requiring thermal oxidation.

Dedicated SCRA handling zones segregate from opioids/benzodiazepines. Annual competency refreshers validate technique proficiency per DEA-exempt protocols.

Packaging, Labeling & Storage

Primary containers employ USP Type I amber glass vials (5-25g) with PTFE septa and crimp seals containing 4Å molecular sieves. Secondary UN 4G/Y18S fiberboard overpacks comply with IATA 7.3 DGR requirements. GHS labels specify UN3077 PG III, brominated organic hazard.

Storage mandates -20°C desiccated (<10% RH) segregated from strong oxidizers/acids. Photostability confirms <1% degradation under ICH Q1B conditions. HPLC-DAD monitors confirm 36-month shelf life integrity.

Intended Research Use & Market Positioning

5BR-ADB-INACA Powder supports forensic NPS screening panels (SWGDRUG 6.0), Phase I metabolism mapping (CYP3A4/2J2), and CB1/CB2 orthosteric binding assays (Ki profiling). Enables QTOF spectral library expansion (>95% match factor), microgram-scale XRD characterization, and β-arrestin recruitment screening.

Targets UNODC Early Warning reference programs, academic SCRA pharmacophore mapping consortia, and forensic CRO confirmation panels. Powder format excels in serial 1:10 calibrations spanning 0.05-500 ng/mL (r²>0.999). Demonstrates regioselective halogen dance rearrangements safely at preparative scale.

Applications extend to wastewater epidemiology brominated SCRA tracking and hepatocyte clearance kinetics.

Ordering, Availability & Fulfillment

WooCommerce platforms offer tiered pricing (1g+ volume discounts) with API-driven real-time inventory. TLS 1.3/3DS2 compliant checkout processes institutional POs. 24-hour dispatch achieves 96% <72h global delivery via DHL/FedEx Priority cold-chain.

Account dashboards enable COA batch history, compliance certificates, and shipment tracking. 99.4% OTIF supports federal forensic grant timelines. Bulk synthesis contracts negotiate custom isotopic labeling.

Legal & Regulatory Disclaimer

5BR-ADB-INACA Powder supplies strictly for research purposes only, not for human or veterinary use, clinical, diagnostic, or therapeutic applications. Buyers independently verify all jurisdictional NPS controls, institutional chemical hygiene oversight, and controlled substance licensing requirements. For research use only. Not for human or veterinary use. Not for clinical, diagnostic, or consumptive applications. Seller disclaims liability for regulatory determinations, misuse, or unauthorized downstream applications.