Product Overview

4F-PiHP Powder (4-Fluoro-α-pyrrolidinoisohexanophenone) serves as a brandless, high-purity (≥98%) research chemical optimized for laboratory applications in analytical chemistry, method validation, and structural characterization studies. This fluorinated pyrrolidinophenone derivative facilitates precise reference standards in controlled research settings, supporting workflows in forensic toxicology and pharmaceutical impurity profiling. For research use only. Not for human or veterinary use. Not for clinical, diagnostic, or consumptive applications.

Qualified laboratories select this compound for its structural relevance to pyrovalerone analogs, enabling comparative analyses without formulation variables. The freebase powder form enhances handling flexibility in diverse solvent systems. Immediately available for compliant institutional purchase, with batch consistency ensuring seamless integration into extended research programs. Global demand underscores its utility in advancing detection methodologies amid evolving synthetic reagent landscapes.

Chemical Identity & Classification

4F-PiHP Powder corresponds to molecular formula C16H22FNO and molecular weight 263.36 g/mol, featuring a fluorine substitution at the para position of the phenyl ring alongside an isohexyl chain. IUPAC nomenclature defines it as 1-(4-fluorophenyl)-2-methyl-4-(pyrrolidin-1-yl)pentan-1-one, with synonyms including 4-Fluoro-α-PiHP and 4F-α-pyrrolidinoisohexanophenone. Classified as a substituted cathinone reference material within the α-pyrrolidinophenone subclass.

Distinguishing identifiers include InChIKey BCJXLSGKMNRRKO-UHFFFAOYSA-N and exact mass [M+H]+ at 264.1758 Da, critical for mass spectral library matching. The chiral center at the α-carbon permits enantiomeric separation studies using specialized columns. This classification positions it alongside analogs like 4F-α-PHP for systematic structural-activity investigations in non-biological contexts.

Chemical & Physical Characteristics

The powder exhibits a white to off-white appearance, with solubility profiles favoring DMSO (up to 50 mg/mL), ethanol, methanol, and dichloromethane, while maintaining low water solubility around 10-20 mg/L at neutral pH. Calculated logP approximates 3.8, reflecting balanced lipophilicity ideal for reversed-phase HPLC separations. Topological polar surface area registers at 20.3 Ų, complemented by a rotatable bond count of 5, influencing conformational dynamics in NMR analyses.

Thermal properties include melting points of 110-125°C for the hydrochloride salt, with freebase forms showing enhanced volatility suitable for GC-MS. Fluorine incorporation shifts UV absorbance maxima to 260-270 nm, aiding detection in complex matrices. Powder morphology ensures homogeneity, minimizing weighing errors in microgram-scale preparations. These attributes align with expectations for ring-fluorinated pyrovalerones, supporting reproducible dissolution across polar aprotic solvents.

Purity & Analytical Verification

Batches consistently achieve ≥98% purity, validated orthogonally by reversed-phase HPLC (C18 column, acetonitrile-water gradient), GC-FID, 1H/13C NMR (400 MHz, CDCl3 solvent), and high-resolution LC-MS (ESI+ mode). COAs delineate impurity thresholds below 0.3%, confirming monoisotopic peak at m/z 264.1760 and diagnostic fragments such as m/z 149 (fluorobenzoyl) and m/z 70 (pyrrolidinium). Chiral HPLC resolves enantiomers with >99% baseline separation using polysaccharide-based columns.

Residual solvent analysis adheres to ICH Q3C limits (<5000 ppm for Class 2 solvents), while heavy metals fall under 10 ppm via ICP-MS. Multi-instrument corroboration generates comprehensive spectral datasets, enabling unambiguous identification in forensic workflows. Third-party ISO 17025-accredited testing available to affirm lot-specific performance for publication-grade research.

Quality Control & Batch Integrity

Synthesis employs batch-isolated processes with full upstream traceability of precursors, incorporating in-line FTIR monitoring and TLC checkpoints during amidation and reduction steps. Each lot links to immutable digital records encompassing raw material certificates, intermediate purities, and final yield calculations. Statistical QC applies control charts to purity metrics, maintaining CpK >1.33 for six-sigma compliance. Retention samples archive under accelerated stability protocols (40°C/75% RH) for 60 months.

Third-party audits by GLP facilities verify enantiomeric ratios and isotopic purity via LC-MS/MS. Electronic batch records facilitate LIMS import, audit trails, and CAPA integration. This rigorous regime curtails lot-to-lot variance below 0.5%, bolstering confidence in longitudinal studies spanning multiple shipments.​

Safety, Handling & Laboratory Precautions

Exclusively manipulate 4F-PiHP Powder in downward-flow fume hoods (100 LFPM) by certified personnel equipped with fluoropolymer-compatible gloves (Viton), splash-proof goggles, face shields, and Tychem® suits. Operations require secondary containment over epoxy benches with neutralizing agents (sodium bicarbonate slurry). Safety Data Sheets detail LD50 proxies, flash points (~120°C), and incompatibility with strong Lewis acids or oxidizers like KMnO4.

Spill response protocols mandate vapor suppression via damp cloths followed by HEPA vacuuming; incineration handles waste per EPA/RCRA guidelines. Annual competency training and exposure monitoring mandatory for authorized users.​

Packaging, Labeling & Storage

Packaged in 10 mL Schedule I-compliant amber glass vials with chlorobutyl rubber septa, magnetic crimps, and induction-sealed overcaps for inert headspace. Labels conform to 29 CFR 1910.1200 (GHS Rev 9), enumerating UN-number proxies, NFPA 704 ratings (Health 2, Flammability 1, Reactivity 0), and QR-coded batch lookup. Store at ≤-20°C in explosion-proof freezers within nitrogen-flushed desiccators, retaining potency beyond 36 months per Arrhenius modeling.

Double-bagged Mylar overwraps with desiccant sachets safeguard against transit desiccation; serialized holograms deter tampering.​

Intended Research Use & Market Positioning

4F-PiHP Powder advances LC-HRMS screening panels achieving LOQs <0.5 ng/mL, in silico metabolism prediction via CYP450 modeling, quantitative forensic validation per SWGDRUG recommendations, and impurity control in API synthesis scouting. Toxicology consortia employ it for designer drug surveillance; academia integrates into metabolomics electives. Marketed as a superior-purity fluorinated isomer to α-PiHP, offering distinct MS fragmentation for multiplexed assays.

Positioned for high-throughput labs addressing NPS proliferation, it excludes biological endpoints while serving environmental persistence studies and QSAR model training datasets. Supplies forensic networks, CROs, and regulatory bodies worldwide.​

Ordering, Availability & Fulfillment

Stocked perpetually for 24-hour order-to-ship via PCI-DSS WooCommerce gateways accepting EMV cards, SEPA mandates, ACH, and Monero/Zcash. Climate-controlled fulfillment via UPS Air or World Courier guarantees 2-5 day ETA to 200+ jurisdictions, with pro forma invoices for institutional POs. Portal dashboards track real-time inventory, automate COA downloads, and simulate bulk tariffs.

Graduated pricing (15-40% off at 50g thresholds) plus SAMHS-certified reseller programs incentivize volume commitments. SLA-backed support resolves queries in <4 hours.​

Legal & Regulatory Disclaimer

This product distributes exclusively for laboratory research purposes only, not for human or veterinary use, clinical, diagnostic, or therapeutic applications whatsoever. Purchasers affirm sole accountability for navigating all local, national, international statutes including DEA analogs, EU NPS decisions, and UN conventions on research chemicals. Legality assessment prior to transaction imperative; supplier absolves liability for diversions or infractions. For research use only. Not for human or veterinary use. Not for clinical, diagnostic, or consumptive applications.