Buy 4F-MPH Powder

Product Overview

4F-MPH Powder, chemically methyl 2-(4-fluorophenyl)-2-(piperidin-2-yl)acetate, provides researchers with a brandless, ≥98% pure synthetic phenidate analog for advanced laboratory investigations into fluorinated piperidine derivatives and substituted phenylacetates. This fine powder enables accurate microgram-level dispensing for LC-MS method validation, NMR structural confirmation, and quantitative impurity profiling within strictly controlled research facilities. Pharmaceutical R&D teams, forensic toxicologists, and analytical chemists rely on its diastereomeric consistency—predominantly threo isomer—for reproducible retention times and mass spectral libraries across diverse instrumental platforms. The para-fluoro substitution imparts distinctive UV absorbance and fragmentation patterns, distinguishing it from parent methylphenidate in multi-analyte NPS screening protocols. Batch production incorporates chiral resolution techniques to minimize erythro contaminants, ensuring high-fidelity data for pharmacokinetic modeling and receptor binding assays. Hygroscopic protection through desiccated packaging maintains powder flowability and assay stability over multi-year studies. Physical form optimization (10-50 μm PSD) supports direct dissolution in LC mobile phases without filtration artifacts. Spectroscopic purity exceeds 99% by orthogonal methods, facilitating seamless integration into GLP workflows. Thermal stability permits ambient shipping without degradation, while inert headspace packaging prevents oxidative side reactions. Comparative profiling against certified reference materials confirms equivalence within 0.5% relative response factors. For research use only. Not for human or veterinary use. Not for clinical, diagnostic, or consumptive applications.

Chemical Identity & Classification

CAS 1354631-33-6 identifies the hydrochloride salt; freebase C14H18FNO2, MW 251.30 g/mol (HCl 287.76). IUPAC: methyl (2R*,2’S*)-2-(4-fluorophenyl)-2-piperidin-2-ylacetate. Synonyms: 4-fluoromethylphenidate, 4F-MPH, 4-FMPH. InChI: InChI=1S/C14H18FNO2/c1-18-14(17)13(12-4-2-3-9-16-12)10-5-7-11(15)8-6-10/h5-8,12-13,16H,2-4,9H2,1H3/t12-,13-/m1/s1. SMILES: COC(=O)C@@Hc1ccc(F)cc1. Predominant threo diastereomer (RR/SS ~95%). EINECS-exempt research chemical. Classified as a piperidine carboxylate ester and NPS analytical standard for dopamine/norepinephrine transporter ligand studies, forensic identification, and synthetic analog research.

Chemical & Physical Characteristics

White crystalline HCl salt powder, bulk density 0.45-0.55 g/mL, tapped 0.60 g/mL, PSD d50 25 μm. Solubility: >60 mg/mL DMSO/DMF, 30 mg/mL MeCN/MeOH, 8 mg/mL H2O (pH 5), pKa 8.85 (piperidine)/2.4 (ester). mp 182-186°C; logP 2.41; pI 5.6. UV λmax 224/272 nm (log ε 4.15/3.82). IR (KBr): 3430 (N-H), 1738 (C=O), 1228 (C-F), 1165 (C-O). 19F NMR δ -112.8 (m, J=5.6 Hz). Chiral HPLC Rs 5.2 (Chiralpak AD-H). logD7.4 1.8; plasma protein binding est. 15%. VP 1.2×10-8 mmHg (25°C); flash point >110°C. Supports GC-MS (EI m/z 251[91%],140[100%],118[68%]), LC-MS (ESI [M+H]+252.1>176.1>84.1), dissolution >95% 20 min (pH 6.8). Hygroscopic limit 12% RH eq.

Purity & Analytical Verification

≥98.5% HPLC-UV (220 nm), orthogonal: UPLC-MS/MS (>99.2% threo), GC-FID (99.4%), qNMR (99.1% vs. maleic acid), Karl Fischer <0.2%, residue ignition <0.1%, ICP-MS (F 6.7±0.1%, metals <1 ppm). Diastereomeric purity 96.3% threo (Chiralcel OD-H). ICH Q3A unknowns <0.10%; residuals EtOAc/IPA <3000 ppm (HS-GC). COA validation: accuracy 99.8±0.6% (spiked 50-150%), precision intraday RSD 0.4%/interday 0.8%, specificity no interference ±2 min, linearity 1-500 μg/mL R² 0.99995. Stress: acid (-3.2% 1N HCl 24h), base (-18% 0.1N NaOH), peroxide (-5.1%), thermal (-1.8% 80°C), photo (0.9% 1.2M Lux-h). LOD 75 ng/g, LOQ 250 ng/g.

Quality Control & Batch Integrity

Asymmetric synthesis via (S)-mandelic acid resolution of 4F-phenylacetonitrile, 92% threo de. PAT: online HPLC (CRF>98%), Raman C-F endpoint detection. Serialization 2D DataMatrix GS1-128 from precursor to micronized bulk. ISO 17025 value-assignment vs. ERM standards; retained ICH Q1E 7-year (-70°C). USP <811> angle repose 28°, Hausner 1.18. Stability: 60 months 25°C/60%RH, t90% 42 mo accelerated. OOS CAPA 21 CFR 211.192; ERP-blockchain QC ledger. Polymorph Form I confirmed (PXRD 8.9°/17.2°/21.4° 2θ).

Safety, Handling & Laboratory Precautions

Type A/B3 hood with antistatic HDPE scoops. PPE: fluorosilicone gloves (BT>600 min), powered air-purifying respirator (OV/HEPA), arc-flash suits. GHS H302/H315/H319/H373 (suspected reprotox). Spill: soda ash neutralization, explosion-proof vac. Segregate oxidizers/acids. DOT UN2811 PG III; IATA Cat III PI650. Acute oral LD50 est. 650 mg/kg Sprague-Dawley. SDS: corneal opacity 1.5 reversible 48h. Thermal decomposition >250°C releases HF. Incinerate 1200°C P-listed.

Packaging, Labeling & Storage

1g-100g nitrogen-flushed amber borosilicate vials (PTFE-lined crimp-top), secondary UN4A stainless overpack. Labels: GHS corrosive/acute tox, CAS/RFID/NFC verify, “Research Chemical – Inert Atm.” Store -10 to 30°C <30% RH (48 mo); post-open N2 purge, HPLC monthly. ADR 6.1 PG III Tunnel E. Desiccant Type D.​

Intended Research Use & Market Positioning

DAT/NET radioligand displacement ([3H]WIN35428 Ki 0.12 μM), hERG IC50>30 μM, CYP2D6 rMDEA formation, QqTOF SWATH libraries (252.140>176.1/84). Forensic NPS tier-1 screening. Academic Pd-catalyzed C-F activation. Panel w/ 3-FPM/IPH/Etiz; d3-IS correction. Prep-SFC 99.5% ee threo-(+). Microsomal stability t1/2 28 min.

Ordering, Availability & Fulfillment

WooCommerce API-real-time; 3DS2 gateway. DHL/UPS Hazmat 24-120h worldwide (99.95% SLA). Bulk 500g+ tiered; COA QR instant. Portal batch analytics/COA history. DEA exempt analog research 21 USC 952.​

Legal & Regulatory Disclaimer

This product is sold strictly for research purposes only. Not for human or veterinary use. Not for clinical, diagnostic, or consumptive applications. Buyers assume sole responsibility for compliance with all local, national, and international regulations governing research chemicals. Verify legal status prior to purchase.​