Buy 4F-MPH 30mg Pellets

Product Overview

4F-MPH 30mg Pellets deliver a brandless, high-purity (≥98%) fluorinated methylphenidate analog, methyl 2-(4-fluorophenyl)-2-(piperidin-2-yl)acetate hydrochloride, specifically engineered for laboratory research into substituted phenidate derivatives and piperidine carboxylate chemistry. The scored 30mg pellet design facilitates precise subdivision for microgram-scale experiments in LC-MS/MS quantitation, chiral HPLC method development, and forensic toxicology screening within certified analytical laboratories. Researchers leverage the predominant threo diastereomer configuration for consistent mass spectral fragmentation patterns and UV detection responses, essential for multi-residue NPS panels and structural elucidation workflows. The para-fluoro moiety imparts unique 19F-NMR signatures and enhanced lipophilicity, enabling comparative studies against parent methylphenidate across diverse chromatographic conditions. Uniform compression minimizes excipient interference, ensuring >99% content uniformity per USP standards for reliable quantitative transfer. Batch synthesis employs stereoselective resolution to achieve >95% threo purity, supporting reproducible pharmacokinetic modeling and receptor binding affinity investigations. Stable matrix withstands ambient storage with <1% degradation over 36 months, ideal for long-term library development. Physical characteristics optimize direct dissolution in acetonitrile gradients without particulate occlusion. For research use only. Not for human or veterinary use. Not for clinical, diagnostic, or consumptive applications.

Chemical Identity & Classification

CAS 1354631-33-6 (HCl salt); freebase C14H18FNO2, MW 251.30 g/mol (salt 287.76). IUPAC: methyl (2R,2S)-2-(4-fluorophenyl)-2-(piperidin-2-yl)acetate hydrochloride (rac-threo). Synonyms: 4-fluoromethylphenidate, 4F-MPH. InChIKey: XISBAJBPDVRSPG-UHFFFAOYSA-N. SMILES: COC(=O)C@@Hc1ccc(F)cc1. Threo:erythro ratio ≥95:5. Classified as a synthetic piperidine phenethylamine analog and analytical reference for dopamine/norepinephrine transporter research, NPS identification, and medicinal chemistry SAR studies.

Chemical & Physical Characteristics

Off-white scored pellets, 7-9 mm diameter, 5-8 kp hardness, friability <0.5% (USP <1216>). API solubility >50 mg/mL DMSO/MeCN, 25 mg/mL MeOH, 6 mg/mL PBS pH7.4. HCl mp 180-187°C (DSC); logP 2.45; pKa 8.9/2.3. UV λmax 226/274 nm. IR: 1742 (C=O), 1232 (C-F), 763 (phenyl). Chiral Rs >4.5 (Lux i-Amylose-1). Dissolution >90% 25 min (pH6.8 USP2). VP <10⁻⁸ mmHg; flash point >115°C. EI-MS m/z 251(92%),140(100%),118(72%); ESI [M+H]+252→176→84. 19F-NMR δ -113.1 ppm. Hygroscopic threshold 15% RH.

Purity & Analytical Verification

≥98.2% HPLC-DAD (220 nm), verified UPLC-QTOF (>99.3% threo), GC-MS (99.5%, SIM 140/252), 1H-NMR (DMSO: δ1.5-2.1 pip, 2.9 pip-H2, 3.72 OCH3, 7.3-7.6 Ar JHF=9 Hz), HRMS (252.1402, Δ1 ppm), F 6.5%, Cl 12.4% (IC). Residuals <2000 ppm solvents, metals <3 ppm. Validation: linearity 5-2000 ng/mL R²0.99997, accuracy 100.2±0.7%, RSD 0.6% (n=15), robustness ±0.1 pH/flow. Stress: acid -2.8%, base -15%, H2O2 -4.2%, photostable.

Quality Control & Batch Integrity

Chiral auxiliary resolution from 4F-mandelic acid, 90% de threo. PAT: FTIR process endpoint, NIR uniformity. GS1 lot traceability API-to-pack. ISO 17025; retained ICH Q1A 60 mo stability. USP <905> CV 0.9%; OOS 0.03%. ERP GMP records 21 CFR 211. PXRD Form A (9.2°/18.1° 2θ).

Safety, Handling & Laboratory Precautions

Downdraft hood with static-free tools. PPE: neoprene gloves (>480 min), APR OV/HEPA, chemical gowns. GHS H302/H319/H373. Spill: vermiculite, NaHCO3 quench. DOT UN2811 PGIII. LD50 est 680 mg/kg. Incinerate 1100°C.

Packaging, Labeling & Storage

30mg Alu-Alu blisters (25-100ct) or HDPE (silica), tamper-evident. Labels GHS, CAS, NFC batch, “Lab Use Only.” Store 18-26°C <40%RH (42 mo); post-open desiccate 120d. IATA PI660.

Intended Research Use & Market Positioning

NPS LC-HRAM (252>176/84), DAT Ki 0.12μM, CYP2D6 N-desF-MPH, hERG>25μM. Forensic tier-1. Analog set MPH/3F-IPH. d6-IS. SFC prep 99.8%ee.

Ordering, Availability & Fulfillment

WooCommerce stock; secure payments. DHL Hazmat 24-96h (99.9%). Bulk discount; COA portal. TSCA exempt.​

Legal & Regulatory Disclaimer

This product is sold strictly for research purposes only. Not for human or veterinary use. Not for clinical, diagnostic, or consumptive applications. Buyers assume sole responsibility for compliance with all local, national, and international regulations governing research chemicals. Verify legal status prior to purchase.​