Buy 4F-MPH 25mg Pellets

Product Overview

4F-MPH 25mg Pellets contain a brandless, ≥98% pure fluorinated methylphenidate analog, methyl 2-(4-fluorophenyl)-2-(piperidin-2-yl)acetate hydrochloride, formulated for laboratory investigations into substituted piperidines and dopamine transporter ligands. The 25mg dosage per pellet streamlines quantitative workflows, eliminating manual weighing errors during LC-MS calibration, NMR quantitation, and enantioselective method development in controlled research settings. Pharmaceutical scientists, forensic analysts, and synthetic chemists employ this material to examine para-fluoro effects on metabolic stability, binding affinities, and ionization efficiencies across analytical platforms. Uniform pellet compression ensures batch homogeneity, supporting reproducible retention times and response factors in multi-residue screening. The threo diastereomer predominance aligns with bioactive MPH stereochemistry, facilitating direct spectral comparisons. Stable under ambient conditions with minimal excipient interference, these pellets integrate seamlessly into GLP-compliant protocols. For research use only. Not for human or veterinary use. Not for clinical, diagnostic, or consumptive applications.

Chemical Identity & Classification

CAS 1354631-33-6 designates the racemic hydrochloride; molecular formula C14H19ClFNO2, molecular weight 287.76 g/mol. IUPAC: methyl (2RS)-2-(4-fluorophenyl)-2-[(2RS)-piperidin-2-yl]acetate hydrochloride. Synonyms: 4-fluoromethylphenidate, 4F-MPH, 4-FMPH. SMILES: [Cl-].COC(=O)C@HC1=CC=C(F)C=C1 (threo). InChIKey: XISBAJBPDVRSPG-UHFFFAOYSA-N. Exists as (±)-threo/(±)-erythro diastereomers (ratio ~95:5 in commercial samples). Classified as a synthetic phenidate analog and NPS reference standard for transporter protein binding assays, toxicological identification, and structure-activity relationship studies in medicinal chemistry.

Chemical & Physical Characteristics

Pellets: biconvex, white-off-white, 6-8 mm diameter, 4-6 kp hardness, <0.8% friability. API solubility: >40 mg/mL DMSO/ACN/MeOH, 15 mg/mL EtOH, 3 mg/mL pH 7.4 buffer. HCl salt mp 178-184°C; freebase logP 2.4, pKa 8.9/2.5. UV λmax 220, 268 nm (ε 14,000). IR: 1740 cm⁻¹ ester C=O, 1225 cm⁻¹ C-F, 1040 cm⁻¹ C-O-C. Chiral HPLC Rs>4 (Lux® Amylose-2). Dissolution t85% <30 min (USP pH 6.8). Thermal stability to 220°C; low volatility (VP<10⁻⁷ mmHg). Supports GC-EI-MS (m/z 251 [M]+, 140/118 base peaks), LC-ESI-MS/MS (252→176→84/130), 19F-NMR (-112 ppm). Hygroscopic; KF <0.3%.

Purity & Analytical Verification

≥98.0% HPLC (214 nm), verified by UPLC-PDA (>99% threo), GC-FID/MS (RT 9.1 min, 99.2%), 1H-NMR (D2O: δ1.4-2.1 m 6H, 2.9 m pip-H2, 3.7 s OCH3, 7.3-7.5 Ar, JHF=8.9 Hz), 19F-NMR (-112.3 ppm), HRMS ([M+H]+ 252.1399, Δ0.8 ppm), Cl 12.3%, F 6.6% (IC/ion-selective). Diastereoselectivity >94%. Residuals: solvents <1500 ppm, inorganics <5 ppm. COA validation: linearity 10-1000 ng/mL R²=0.9999, accuracy 100.1±0.9%, precision RSD 0.7% (n=12), robustness ±10% flow/0.2 pH. ICH stress testing: acid/base/thermal/photo stable >95% 24h.

Quality Control & Batch Integrity

Multi-step resolution from 4F-phenylacetonitrile via chiral auxiliary, 88% threo yield. In-line Process Analytical Technology (PAT): Raman (C-F stretch endpoint), NIR content uniformity. Lot serialization GS1 DataMatrix from API to OTC. ISO 17025/ISO 17034 accredited; retained ICH Q1E/R standards (-80°C). USP <905>/<711> compliant (CV<1.0%, f2>50). Stability: 48 mo RT, 6 mo 40°C/75%RH. OOS rate 0.04%; 21 CFR 211 digital batch record.

Safety, Handling & Laboratory Precautions

Aseptic dissection in Type B2 hoods; static-dissipative plasticware. PPE: Viton® gloves (>480 min), PAPR organic vapor/acid gas, Tychem® suits. GHS H302/H315/H319/H373. Spill protocol: vermiculite, neutralize NH4HCO3, HEPA-M Class vacuum. Segregate from strong oxidizers. DOT UN2811 PG III. Est. LD50 700 mg/kg oral rodent. Incineration >1000°C RCRA P-listed. SDS rabbit eye score 1.2 (reversible).​

Packaging, Labeling & Storage

25mg in 10-100 count Alu-Alu blisters or desiccated HDPE (32 dram, 2g silica), tamper-evident. Labels: GHS DANGER, CAS, RFID/NFC batch verify, “Research Use Only.” Store 15-25°C/30-50% RH (36 mo expiry); post-open 90-day assay. IATA PI 660 Cat II air; UN3373 biological exempt.

Intended Research Use & Market Positioning

NPS toxicology screening (MRM 252→176/84/130), DAT/NET/SERT Ki profiling, CYP2D6/3A4 metabolism (N-dealkyl major), in vitro hERG patch clamp. Academic: asymmetric synthesis demos. Analog panel with IPH/3FPMH; IS d6-4F-MPH. Prep-chiral SFC >99% ee.

Ordering, Availability & Fulfillment

WooCommerce live inventory; 256-bit SSL payments. Fulfillment UPS/DHL 24-72h global (99.9% SLA). Bulk pellet MOQ 1k units discounted. COA instant download; 24/7 batch portal. TSCA research notification compliant.

Legal & Regulatory Disclaimer

This product is sold strictly for research purposes only. Not for human or veterinary use. Not for clinical, diagnostic, or consumptive applications. Buyers assume sole responsibility for compliance with all local, national, and international regulations governing research chemicals. Verify legal status prior to purchase.​