Buy 4F-MPH 15mg Pellets

Product Overview

4F-MPH Pellets 15mg provide a brandless, high-purity (≥98%) fluorinated analog of methylphenidate, chemically methyl 2-(4-fluorophenyl)-2-(piperidin-2-yl)acetate, designed exclusively for laboratory research into substituted phenidate scaffolds and piperidine derivatives. The compact 15mg pressed pellet format ensures accurate, reproducible sample introduction for LC-MS quantitation, chiral separations, and metabolic profiling in controlled analytical environments. Researchers in pharmaceutical R&D, forensic toxicology, and academic synthetic chemistry utilize this material to investigate fluorine substitution effects on lipophilicity, receptor affinity modeling, and fragmentation pathways. Batch consistency supports multi-site collaborations, with low intra-lot variation critical for validated method transfers. The piperidine ring and para-fluoro phenyl enhance spectroscopic distinguishability from parent MPH, aiding NPS identification workflows. Stable excipient matrix prevents deliquescence, maintaining assay integrity over extended storage. For research use only. Not for human or veterinary use. Not for clinical, diagnostic, or consumptive applications.

Chemical Identity & Classification

4F-MPH holds CAS 1354631-33-6 (racemic hydrochloride), with molecular formula C14H18FNO2 and molecular weight 251.30 g/mol. IUPAC name: methyl (2R)-2-(4-fluorophenyl)-2-[(2R)-piperidin-2-yl]acetate (threo diastereomer dominant). Synonyms: 4-fluoromethylphenidate, 4-FMPH, (±)-threo-4F-MPH. InChI: InChI=1S/C14H18FNO2/c1-18-14(17)13(12-4-2-3-9-16-12)10-5-7-11(15)8-6-10/h5-8,12-13,16H,2-4,9H2,1H3/t12-,13-/m1/s1. SMILES: COC(=O)C@@HC2=CC=C(C=C2)F. Classified as a synthetic cathinone/phenidate analog and analytical reference standard for dopamine/norepinephrine transporter studies and novel psychoactive substance (NPS) surveillance.

Chemical & Physical Characteristics

Pellets exhibit white to off-white coloration, uniform diameter 4-6 mm, hardness 5-7 kp, friability <0.5%. Active solubility: >50 mg/mL DMSO, MeOH, ACN; 20 mg/mL EtOH; 5 mg/mL PBS pH 7.4. HCl salt mp 180-185°C (DSC); logP 2.42; pKa 8.4 (piperidine), 2.3 (carboxylate). UV λmax 225, 270 nm. IR: 1735 cm⁻¹ (C=O ester), 1210 cm⁻¹ (C-F), 750 cm⁻¹ (phenyl). Chiral purity threo:erythro >95:5; [α]_D +25° (c=1, MeOH). Dissolution >90% 45 min (USP App 2, pH 6.8). Flash point >100°C; low volatility suitable for HS-GC. These support EI-MS (m/z 251 [M]+, 140 base), ESI-MS/MS (176→84, 130), and CE enantioseparation (Rs 3.2, γ-CD). Hygroscopic; desiccate storage essential.

Purity & Analytical Verification

Batches ≥98.5% pure (HPLC, 220 nm), verified by RP-UPLC-DAD (>99% diastereoselectivity), GC-MS (RT 8.2 min, SIM 140/251), ¹H-NMR (CDCl3: δ 1.45-2.05 m 6H pip, 2.75 m 1H pip-H2, 3.75 s 3H OCH3, 7.05 dd 2H Ar, 7.25 dd 2H Ar-F), HRMS ([M+H]+ 252.1400, Δ1.2 ppm), ICP-MS (F 4.8%, metals <2 ppm). Residual solvents <300 ppm (EtOAc, IPA); no cyanide/peroxides. COA includes linearity (5-500 ng/mL, R² 0.9998), precision (RSD 1.2% n=6), accuracy 99.5±1.1%, forced degradation (acid 5% loss, base 20%, H2O2 8%). USP <621> chromatography match. Digital lot certificates scannable via app.

Quality Control & Batch Integrity

Eutectic synthesis from 4-fluorophenylacetonitrile, resolved via tartaric acid, yields 85% threo. In-process Raman (99% CE endpoint), NIR tablet assay (RSD<1%). Full traceability via GS1-128 barcodes from API to pack-out. ISO 17034 accredited value assignment; retained standards ICH Q1B photostability confirmed. cGMP ISO 8 cleanrooms; OOT 0.05% rate. Uniformity USP <905> k=30 CV 0.8%; stability 48 months (25°C/60%RH). ERP-blockchain hybrid audit trail for DEA 21 CFR 1310 compliance.

Safety, Handling & Laboratory Precautions

Fume hood dissection with Teflon spatulas; grounded antistatic precautions (resistivity 10¹¹ Ωcm). PPE: neoprene gloves (480 min permeation), half-face APR (OV/Acid gas), lab coat. GHS Acute Tox 4 H302, Eye Irrit 2 H319, STOT RE 2 H373. Spill: inert absorbent, ventilate, IPA wipe-down. Segregate amines/acids. Est. LD50 800 mg/kg oral; DOT UN2811 PG III. Prohibit ignition (class 9 hazmat). SDS LD50 dermal >2000 mg/kg rat. Dispose EPA P-listed incineration.​

Packaging, Labeling & Storage

15mg in Alu-Alu blisters (10-50/pack) or HDPE DR bottles (100 count) with 2g silica, tamper-evident seals. Labels: GHS, CAS 1354631-33-6, “Research Chemical,” RFID inventory. Store 15-30°C (<40% RH), 36-month shelf life; post-open desiccate/use 60 days. IATA PI 660 air compliant; UN3373 if diagnostic exempt.​

Intended Research Use & Market Positioning

Forensic NPS panels (SWATH HRMS 252>176/84), DAT/NET uptake inhibition screening (Ki nM range), CYP2D6 metabolism (major N-desmethyl), chiral PK modeling. Academic synth projects (asymmetric Mannich). Complements MPH/3FPMH/Etizolam analogs; matrix-matched IS d3-4F-MPH. Industrial impurity profiling (>98% prep-SFC).

Ordering, Availability & Fulfillment

WooCommerce real-time stock; 3D Secure payments. Ships UPS Next Day Air (US), DPD (EU) 24-72h, 99.8% OTIF. Bulk 1k+ pellets discounted; COA instant PDF. Portal for re-order/COA archive. TSCA-listed research exempt.​

Legal & Regulatory Disclaimer

This product is sold strictly for research purposes only. Not for human or veterinary use. Not for clinical, diagnostic, or consumptive applications. Buyers assume sole responsibility for compliance with all local, national, and international regulations governing research chemicals. Verify legal status prior to purchase.​