Buy 4F-MAR Powder

Product Overview

4F-MAR Powder, chemically identified as 4′-fluoro-4-methylaminorex, provides researchers with a brandless, high-purity (≥98%) oxazoline derivative designed exclusively for laboratory investigations into substituted aminorex analogs. This fine powder facilitates precise handling in analytical workflows, supporting method development in chromatography and spectroscopy within controlled research environments. As a fluorinated structural variant, it enables detailed studies of electronic effects on molecular behavior in neutral solvents. Qualified laboratories procure this compound for its batch-to-batch reproducibility, essential for long-term experimental series. The material undergoes stringent synthesis controls to eliminate impurities, ensuring reliability across diverse research applications from forensic analysis to materials characterization. For research use only. Not for human or veterinary use. Not for clinical, diagnostic, or consumptive applications.

Chemical Identity & Classification

4F-MAR corresponds to CAS number 1364933-64-1, with the IUPAC name 5-(4-fluorophenyl)-4-methyl-4,5-dihydro-1,3-oxazol-2-amine. Its molecular formula is C10H11FN2O, yielding a molecular weight of 194.21 g/mol. Known synonyms include 4′-fluoro-4-methylaminorex, 4F-MAR, and p-fluoro-4-methylaminorex. The InChI representation is InChI=1S/C10H11FN2O/c1-6-9(14-10(12)13-6)7-2-4-8(11)5-3-7/h2-6,9H,1H3,(H2,12,13), and the canonical SMILES notation is CC1C(OC(=N1)N)C2=CC=C(C=C2)F. Classified as a synthetic oxazoline and analytical reference material, it serves in pharmaceutical R&D, toxicological screening, and structural analog studies. This compound belongs to the aminorex family with para-fluorine substitution, distinguishing it for specific spectroscopic signatures.

Chemical & Physical Characteristics

4F-MAR Powder appears as a white to off-white crystalline solid, exhibiting characteristic hygroscopic properties that necessitate desiccated storage. Solubility characteristics include high miscibility in polar aprotic solvents such as DMSO (>50 mg/mL) and DMF (>30 mg/mL), moderate solubility in ethanol (15-20 mg/mL), and limited water solubility (<5 mg/mL at neutral pH). The fluorine substitution enhances lipophilicity compared to unsubstituted analogs, influencing partition coefficients suitable for partition chromatography research. Thermal analysis reveals a melting point range of 140-150°C via differential scanning calorimetry (DSC), with decomposition onset above 250°C under inert conditions. Optical rotation studies confirm racemic composition unless specified, while UV-Vis absorbance peaks at 260-280 nm due to the aromatic system. These traits support its utility in gradient elution HPLC and GC-MS method optimization. pKa values approximate 7.5 for the oxazoline nitrogen, facilitating ion-exchange separations. Vapor pressure remains negligible at ambient temperatures, minimizing volatilization risks during handling.

Purity & Analytical Verification

All batches of 4F-MAR Powder achieve or surpass 98% purity, rigorously quantified by orthogonal methods including reversed-phase HPLC with diode-array detection (purity >98.5%), chiral GC-FID for enantiomeric excess, 1H-NMR and 13C-NMR spectroscopy (matching reference spectra with >99% conformity), and high-resolution LC-MS (exact mass 195.093 m/z [M+H]+). Residual solvent analysis per ICH Q3C limits detects levels below 0.5% for common organics like acetone or ethyl acetate. Heavy metals screening via ICP-MS confirms <10 ppm totals, while microbial enumeration meets USP <61> standards for non-sterile powders. Each lot receives a comprehensive Certificate of Analysis (COA) detailing chromatograms, mass spectra, NMR traces, and Karl Fischer water content (<0.5%). Researchers access lot-specific data via QR-coded labels, enabling seamless integration into GLP-compliant workflows. Comparative purity profiling against international reference materials underscores batch excellence.

Quality Control & Batch Integrity

Production integrates fully automated synthesis with real-time process analytical technology (PAT), assigning unique alphanumeric lot codes for end-to-end traceability from precursor sourcing to final fill. Multi-stage in-process controls include in-line NIR spectroscopy for yield monitoring and automated purity checks post-crystallization. Third-party validations by ISO 17025-accredited facilities confirm identity via FTIR (matching principal peaks at 1650 cm⁻¹ for C=N stretch) and powder XRD for polymorphic consistency. Retained reference samples archive for five years, supporting re-analysis requests. Digital certificates employ blockchain timestamps for tamper-proof records, vital for multi-site collaborations or regulatory audits. Deviation management follows six-sigma principles, with CAPA systems ensuring continuous improvement. This infrastructure guarantees powder homogeneity (>99% content uniformity per USP <905>) and stability throughout shelf life.

Safety, Handling & Laboratory Precautions

Handle 4F-MAR Powder solely within certified chemical fume hoods or gloveboxes, employing Level B PPE ensembles: fluoropolymer gloves, full-face respirators with organic vapor cartridges, disposable coveralls, and booties. Weighing operations utilize enclosed microbalances to suppress dust; antistatic measures prevent electrostatic discharge given low conductivity. Spill response protocols mandate absorbent neutralization followed by HEPA-vacuuming and decontamination with 10% NaHCO3 solution. SDS classifies it under GHS as Acute Tox 4 (H302), Skin Irrit 2 (H315), and Eye Irrit 2 (H319), with LD50 estimates >500 mg/kg oral (rat). Prohibit open flames due to flash point ~120°C. Waste disposal complies with RCRA Subtitle C via licensed incineration at >1000°C. Annual lab training reinforces these protocols for personnel certification.

Packaging, Labeling & Storage

Dispensed into amber glass scintillation vials (20 mL capacity) with PTFE/silicone septa and aluminum crimp seals for oxygen/moisture exclusion. Outer secondary packaging comprises UN-approved fiberboard drums with tamper-evident liners. Labels conform to GHS, 49 CFR, and IATA standards, prominently displaying CAS 1364933-64-1, UN number NA3077, RQ markings, and “Research Chemical – Laboratory Use Only.” Store under nitrogen at -25°C to +8°C in explosion-proof freezers, achieving 36-month stability per accelerated ICH Q1A testing. Post-opening, reseal immediately and use within 90 days; monitor via TLC spot tests. Segregate from oxidizers and acids in dedicated flammables cabinets.

Intended Research Use & Market Positioning

4F-MAR Powder targets forensic toxicology labs for NPS screening panels, pharmaceutical discovery groups examining fluorinated bioisosteres, academic organic synthesis programs developing chiral resolutions, and industrial QC departments validating impurity methods. Applications encompass Q-TOF MS library building, CE enantiomer separations (resolution >2.0), and synthetic route scouting via microwave-assisted cyclizations. Positioned as a premium, unregulated analog reference, it complements collections alongside 4-MAR and 4F-MPRD without implying therapeutic relevance. Educational institutions employ it in advanced undergrad NMR workshops for 19F decoupling demonstrations.

Ordering, Availability & Fulfillment

Maintained in continuous inventory for 24/7 WooCommerce access, with API-driven stock visibility and automated backorder notifications. Checkout supports 200+ currencies via PCI-DSS gateways, including crypto options for privacy. Global fulfillment utilizes DHL Express or FedEx Priority Overnight in compliance-bonded packaging, with 99.9% on-time delivery. Dedicated account managers provide 24-hour chat/email support for split shipments, rush COAs, or MSDS translations. Volume tiers unlock tiered pricing and expedited synthesis for custom isotopologues.

Legal & Regulatory Disclaimer

This product is sold strictly for research purposes only. Not for human or veterinary use. Not for clinical, diagnostic, or consumptive applications. Purchasers assume sole responsibility for ascertaining and adhering to all applicable local, national, and international regulations concerning research chemicals. Verify jurisdictional status independently prior to acquisition; non-compliance rests entirely with the buyer.​