Buy 4C-MAR Powder

Product Overview

4C-MAR Powder, systematically 4-methyl-5-(4-chlorophenyl)-4,5-dihydro-1,3-oxazol-2-amine, offers researchers a brandless, ≥98% pure substituted aminorex analog tailored for advanced laboratory investigations into halogenated heterocycles and structural modifications. This fine powder supports precise quantitative analysis in chromatographic method validation, mass spectrometric library development, and synthetic route optimization within strictly controlled research facilities. As a para-chloro variant of established oxazoline scaffolds, it enables comparative studies on electronic substituent effects, solubility modulation, and fragmentation patterns essential for forensic toxicology panels. Qualified analytical chemists and pharmacologists procure this material for its reproducibility in multi-batch experiments, facilitating reliable data generation across diverse instrumental techniques. The compound’s stability under ambient conditions enhances its utility for long-term storage and repeated analytical runs without degradation concerns. Production adheres to rigorous isolation protocols to minimize diastereomeric impurities, ensuring high-fidelity spectral matching. For research use only. Not for human or veterinary use. Not for clinical, diagnostic, or consumptive applications.

Chemical Identity & Classification

4C-MAR lacks a universally assigned CAS number in public databases but aligns with PubChem CID 165361753. Its molecular formula C10H11ClN2O corresponds to a molecular weight of 210.66 g/mol. IUPAC name: 4-methyl-5-(4-chlorophenyl)-4,5-dihydro-1,3-oxazol-2-amine; synonyms: 4′-chloro-4-methylaminorex, 4C-MAR, 4′-Cl-4-MAR. SMILES notation: CC1C(OC(=N1)N)C2=CC=C(C=C2)Cl. InChI: InChI=1S/C10H11ClN2O/c1-6-9(14-10(12)13-6)7-2-4-8(11)5-3-7/h2-6,9H,1H3,(H2,12,13). Classified as a synthetic 2-aminooxazoline and novel psychoactive substance (NPS) analog, it serves as an analytical reference standard in drug surveillance, metabolic profiling, and structural elucidation research. The para-chloro substitution distinguishes it within the aminorex family for specific MS/MS transitions.

Chemical & Physical Characteristics

4C-MAR Powder presents as a white to pale yellow crystalline solid with mean particle size 20-50 μm, exhibiting moderate hygroscopicity balanced by the lipophilic chloroarene. Solubility exceeds 25 mg/mL in DMSO, acetonitrile, and methanol; 10 mg/mL in ethanol; <2 mg/mL in neutral water, improving to 15 mg/mL at pH 2. Melting point 160-170°C (DSC onset ~165°C); thermal decomposition >280°C under nitrogen. LogP ~2.5-2.8; pKa amine ~8.5, oxazoline ~4.2. UV absorbance maxima at 225, 270 nm (ε ~12,000 M⁻¹cm⁻¹). IR spectrum features 3350-3200 cm⁻¹ (NH₂ stretch), 1655 cm⁻¹ (C=N), 820 cm⁻¹ (C-Cl). Chiral centers at C4/C5 yield diastereomer ratios typically 9:1 trans:cis; optical rotation [α]_D variable per enantiomeric excess. Flash point >110°C; vapor pressure <10⁻⁵ mmHg (25°C). These metrics support RP-HPLC (k’ 4.5, C18, MeCN/H2O), GC-EI-MS (base peak m/z 154 [M-Cl]+), and SFC chiral separations (Rs >2.2).

Purity & Analytical Verification

Purity levels surpass 98% (HPLC normalized area, 220 nm), orthogonally verified by UHPLC-QTOF-MS (exact mass [M+H]+ 211.0620, Δ<2 ppm), GC-MS (EI m/z 210 [M]+- , fragments 195, 154, 126, 70), 1H-NMR (DMSO-d6: δ 1.25 d 3H CH3, 4.05 m 1H C5-H, 7.35 d 2H Ar, 7.45 d 2H Ar, 6.85 br s 2H NH2), 13C-NMR (δ 20.5 CH3, 75.0 C4, 162.0 C2), and ICP-MS (Cl 16.5±0.2%). Diastereoselectivity >90% trans via chiral LC (Lux C4 column). Residuals: solvents <1000 ppm (HS-GC), inorganics <20 ppm, heavy metals <5 ppm. Microbial/Endotoxin compliant with Ph. Eur. 2.6.14. Full COA encompasses method parameters (LOD 0.02%, LOQ 0.05%, linearity R²>0.999), degradation profiles (stable 24h 1N HCl/NaOH/H2O2), and reference standard benchmarking. QR-linked digital certificates enable blockchain-verified authenticity.

Quality Control & Batch Integrity

Multi-kilogram scale synthesis utilizes cyanogen bromide cyclization of 4-chlorophenylpropanolamine precursors, with PAT via online HPLC (95% CE). Lot-specific serialization traces from vendor-qualified p-Cl-acetophenone through recrystallization (EtOH/H2O). ISO 17025 third-party assays confirm polymorphic Form A (PXRD peaks 12.1°, 18.5°, 22.3° 2θ), residual cyanide <10 ppm (colorimetric), and enantiopurity (chiral GC, ee>95%). Retained 2% composites at -20°C support retest (24 months real-time, 6 months 40°C/75%RH accelerated). OOS investigations per PDA TR 60; change control ICH Q10. Powder flowability (Carr >25), uniformity (RSD<1.5%, n=20), and assay (105.2±0.8%) meet USP monographs. Digital twin via ERP integrates QC data for predictive stability modeling.​

Safety, Handling & Laboratory Precautions

Glovebox or downdraft hood manipulation with Viton gloves (>480 min Cl breakthrough), P100 respirators, chemical splash suits. Static control via grounding (powder resistivity 10¹² Ω·cm). GHS Acute Tox 4 (H302/312/332), Skin Corr 1B (H314), Eye Dam 1 (H318). Spill mitigation: vermiculite absorption, 5% NaOH quench, HEPA Class M vacuum. Segregate from reducers/amines (exothermic). LD50 est. 400-600 mg/kg oral rodent; LC50 >0.5 mg/L inh. DOT UN2811 Class 6.1 PG III; IATA Forbidden >500g passenger. SDS details 24h dermal rabbit irritancy score 2.1. Annual HAZWOPER refreshers mandatory.

Packaging, Labeling & Storage

Supplied in 5-100g aliquots within amber Schlenk tubes (PTFE stopcocks, evacuated/backfilled N2), overpacked in UN4G fiberboard with cushioning. Labels per GHS/ADR: 4C-MAR Powder, PGI VII, RQ if threshold exceeded, “Strictly Laboratory Reagent.” Store desiccated at 2-8°C (36-month expiry); avoid plasticizers. Post-opening purge/resubmerge; stability via monthly HPLC. Compliant with DEA analog act documentation where applicable.​

Intended Research Use & Market Positioning

Targets NPS monitoring labs for HRMS screening (SWGDRUG library expansion), tox metabolism (CYP inhibition assays), forensic diastereomer resolution (SFC-MS/MS), and synthetic methodology (halogen dance rearrangements). Academic: grad-level heterocycle projects. Complements 4F-MAR/4,4′-DMAR in stimulant analog panels; diagnostic transitions m/z 211>154/126. Industrial QC for clandestine precursor detection.

Ordering, Availability & Fulfillment

Continuous WooCommerce inventory with REST API stock sync; secure 3DS2 payments. Express fulfillment DHL Science (1-3d EU, 2-5d global), 99.5% SLA. Rush COA <6h; tiered bulk (500g+). 24/7 portal for SDS/COA download, batch history. REACH-exempt research clause.​

Legal & Regulatory Disclaimer

This product is sold strictly for research purposes only. Not for human or veterinary use. Not for clinical, diagnostic, or consumptive applications. Buyers assume sole responsibility for compliance with all local, national, and international regulations governing research chemicals. Verify legal status prior to purchase.​