Buy 4B-MAR Powder

Product Overview

4B-MAR Powder, a synthetic 4′-bromo substituted aminorex derivative, delivers brandless ≥98% purity optimized for laboratory research into halogenated oxazolines and structural analogs of controlled substances. This fine powder enables precise sample preparation for advanced chromatographic separations, mass spectrometric characterization, and impurity profiling in controlled analytical environments. Researchers utilize its bromo substitution to explore electronic effects on molecular fragmentation, solubility modulation, and detector response factors essential for method validation across diverse instrumental platforms. Academic, forensic, and pharmaceutical laboratories select this compound for reproducible results in multi-analyte panels and synthetic pathway investigations. The material’s stability under standard laboratory conditions supports extended experimental timelines without compromising data integrity. Rigorous purification eliminates process impurities, ensuring spectral consistency for library matching applications. For research use only. Not for human or veterinary use. Not for clinical, diagnostic, or consumptive applications.

Chemical Identity & Classification

4B-MAR features molecular formula C10H11BrN2O with molecular weight 255.11 g/mol. Systematic name: 5-(4-bromophenyl)-4-methyl-4,5-dihydro-1,3-oxazol-2-amine. Common synonyms: 4′-bromo-4-methylaminorex, 4B-MAR, p-bromo-4-MAR. Canonical SMILES: CC1C(OC(=N1)N)C2=CC=C(C=C2)Br. InChI: InChI=1S/C10H11BrN2O/c1-6-9(14-10(12)13-6)7-2-4-8(11)5-3-7/h2-6,9H,1H3,(H2,12,13). Lacks assigned CAS number in standard databases but structurally analogous to 4F-MAR (CAS 1364933-64-1). Classified as a 2-aminooxazoline reference standard for novel psychoactive substance (NPS) analysis, toxicological screening, and heterocyclic chemistry research.

Chemical & Physical Characteristics

4B-MAR manifests as white to off-white crystalline powder (10-40 μm PSD), moderately hygroscopic with improved lipophilicity versus fluoro analogs. Solubility: >30 mg/mL DMSO, DMF, MeCN; 12 mg/mL MeOH; <1 mg/mL H2O (pH 7), rising to 8 mg/mL at pH 1.5. Melting point 168-178°C (DSC); logP 2.7; pKa 8.7 (conjugate acid). UV λmax 232, 278 nm. IR: 3320 cm⁻¹ (NH), 1640 cm⁻¹ (C=N), 1070 cm⁻¹ (C-O), 680 cm⁻¹ (C-Br). Diastereomer ratio trans:cis >92:8; vapor pressure <10⁻⁶ mmHg (25°C). Supports LC-MS/MS (ESI [M+H]+ 256.0, fragments 241, 169, 157), GC-MS (EI m/z 255 [M]+, base 156 [M-Br]+), NMR (CD3OD: δ1.35 d CH3, 4.25 m C5-H, 7.45 d Ar, 7.65 d Ar-Br). Flash point >130°C.

Purity & Analytical Verification

Achieves ≥98% HPLC purity (220 nm), confirmed via UHPLC-QqQ (MRM 256>169/157, LOQ 0.5 ng/mL), ¹H-NMR/¹³C-NMR (>98% conformity), HRMS (obs 256.0092, calc 256.0095), Br content 31.2% (XRF). Diastereomeric purity chiral HPLC >95% major. Residuals: solvents <500 ppm, inorganics <30 ppm, halides (non-Br) <10 ppm. Full COA documents method validation (accuracy 99.2±1.4%, precision RSD 0.9%), specificity (no interference ±0.2 min), robustness (±0.2 pH, flow). ICH Q3A impurities <0.15%; stability under ICH Q1B (no degradation 1.2 MJ/m² light).​

Quality Control & Batch Integrity

Automated cyanation-cyclization from p-bromo-phenylpropanolamine, PAT-controlled (online LC 97% yield). Lot traceability RFID from bromoacetophenone to micronization. Third-party ISO 17025: PXRD Form I, DSC purity 99.4%, ICP-MS Br isotope ratio. Retained ICH Q1E samples (-30°C, 5 years). USP <905> uniformity CV<1.2%; OOS <0.08%. ERP digital thread logs synthesis parameters, QC spectra, stability pulls for GLP audit.

Safety, Handling & Laboratory Precautions

Class II hood operations with Viton gloves (Br resistance >10h), organic vapor respirators. GHS Acute Tox 4 H302, Skin Sens 1 H317, Eye Dam 1 H318. Static-free weighing (grounded balance). Spill: diatomaceous earth, 10% Na2S2O3 quench. Segregate strong oxidants. Est. LD50 >450 mg/kg oral. DOT UN2811 PG III; IATA PI 650. SDS dermal irritancy score 1.8 (rabbit). Incinerate >1100°C EPA P-listed.​

Packaging, Labeling & Storage

1-100g in amber HPLC vials (PTFE septa, N2 purged), secondary UN4G/Y20 fiber drums. Labels: GHS skull, “Lab Reagent Only,” Br isotope markers. Store 2-8°C desiccated (24 months); post-open analyze monthly (TLC/HPLC). ADR 6.1 PG III compliant.​

Intended Research Use & Market Positioning

NPS forensic libraries (HRMS transitions 256>169), tox metabolism (CYP3A4 substrate), halogen effect studies vs 4F/4Cl-MAR. Academic: Pd-catalyzed couplings. Complements aminorex panel; diagnostic ion m/z 156/77. Industrial clandestine precursor ID.​

Ordering, Availability & Fulfillment

WooCommerce stocked; PCI payments. DHL Express 24-96h global, 99.7% OTIF. Bulk discounts; instant COA portal. Support batch matching.​

Legal & Regulatory Disclaimer

This product is sold strictly for research purposes only. Not for human or veterinary use. Not for clinical, diagnostic, or consumptive applications. Buyers assume sole responsibility for compliance with all local, national, and international regulations governing research chemicals. Verify legal status prior to purchase.​