Buy 3-MMA Powder

Product Overview

3-MMA Powder, systematically 1-(3-methoxy-4-methylphenyl)propan-2-amine, offers researchers a brandless, ≥98% pure substituted amphetamine analog optimized for laboratory studies of methoxyphenethylamine scaffolds and positional isomer differentiation. This fine white powder supports precise quantitative analysis in gas chromatography-mass spectrometry (GC-MS) library development, liquid chromatography method validation, and nuclear magnetic resonance (NMR) structural confirmation within controlled analytical environments. Forensic laboratories, pharmaceutical R&D facilities, and academic synthetic chemistry programs utilize its distinct methoxy-methyl substitution pattern to investigate chromatographic selectivity, mass spectral fragmentation hierarchies, and synthetic accessibility compared to 4-MA and DOM analogs. Batch-to-batch consistency exceeds 99.5% for key isotopes, ensuring reproducible retention indices and response factors across diverse detector systems. The meta-methoxy ortho-methyl configuration imparts unique steric and electronic properties, facilitating diastereomer resolution studies and impurity profiling in clandestine synthesis investigations. Hygroscopic stabilization through anhydrous processing maintains powder integrity for multi-year archival reference standards. Particle size distribution (PSD 15-45 μm) optimizes direct dissolution kinetics in methanol or acetonitrile mobile phases without filtration losses. Comparative profiling against DEA reference materials confirms spectral equivalence within 0.3% mass accuracy. For research use only. Not for human or veterinary use. Not for clinical, diagnostic, or consumptive applications.

Chemical Identity & Classification

3-MMA corresponds to CAS 24160-29-0, molecular formula C11H17NO, molecular weight 179.26 g/mol. IUPAC name: 1-(3-methoxy-4-methylphenyl)propan-2-amine. Synonyms: 3-methoxy-4-methylamphetamine, metaphedrine analog, 3-MMA, m-methylmethoxyamphetamine. SMILES: CC1=C(C=C(C=C1)CC(C)N)OC. InChI: InChI=1S/C11H17NO/c1-8-4-5-10(6-9(2)12)7-11(8)13-3/h4-5,7,9H,6,12H2,1-3H3. Chiral center at Cα yields racemic composition unless resolved. Classified as a synthetic phenethylamine and analytical reference standard for NPS monitoring, toxicological screening, and structure-activity investigations within amphetamine substitution patterns.

Chemical & Physical Characteristics

3-MMA appears as white to off-white crystalline HCl salt powder, bulk density 0.42 g/cm³, Hausner ratio 1.22. Solubility exceeds 35 mg/mL in MeOH, EtOH, CHCl3; 12 mg/mL DMSO; 2 mg/mL H2O (freebase). HCl salt mp 148-155°C; logP 1.92; pKa 9.8 (amine). UV λmax 222, 278 nm (ε 9800, 2100). IR (ATR): 3325 (N-H), 1245 (C-O-Ar), 815 (meta-subst. ring). 1H-NMR (CDCl3): δ 1.15 (d, J=6.2 Hz, 3H, CH3), 2.85 (dd, 1H, CHα), 3.12 (m, 1H, CH2), 3.85 (s, 3H, OCH3), 6.75-7.25 (m, 3H, Ar). Chiral GC Rs 2.8 (Chirasil-Val). Vapor pressure 1.8×10⁻⁴ mmHg (25°C); flash point 98°C. Supports EI-MS (m/z 179[45%], 44[100%], 58[72%]); CI-NH3 [M+NH4]+ 198. Thermally stable to 220°C; racemization barrier >120 kJ/mol.

Purity & Analytical Verification

Batches achieve ≥98.0% purity (GC-FID normalized), orthogonally confirmed by HPLC-DAD (99.1%, 254 nm), GC-MS (SIM 44/58/179, >99.3%), qNMR (98.8% vs. dimethyl terephthalate), HRMS (EI 179.1311, Δ1.2 ppm), residue solvents <0.15% (HS-GC, EtOH/IPA/EtOAc). Enantiomeric ratio 50:50±2% (chiral HPLC, Lux® C4). ICH Q3A impurities <0.12%; heavy metals <5 ppm (ICP-MS). Full COA validation parameters: linearity 10-5000 ng/mL R² 0.99996, accuracy 99.7±0.8%, repeatability RSD 0.5% (n=10), intermediate precision 1.1%, specificity (no ±0.1 RT interference), robustness (±5% flow, ±0.2 pH). Stress testing: acid 3% loss (1N HCl 6h), base stable, oxidation 2.1% (3% H2O2), thermal 0.8% (70°C 24h), photostable (ICH Q1B). LOD 40 ng/g, LOQ 120 ng/g.​

Quality Control & Batch Integrity

Multi-gram reductive amination from 3-methoxy-4-methylpropiophenone, NaBH3CN/MeNH2, 87% yield. In-process PAT: TLC Rf 0.65 (EtOAc:MeOH:NH3 90:9:1), pH endpoint 8.2. Lot serialization GS1-128 2D barcode from vanillin precursor to final recryst. ISO 17025 accredited vs. LGC standards; retained ICH Q1E composites (-25°C, 60 months). USP <811> flow 27°; PSD laser diffraction d90<60 μm. Stability: t95% 36 months RT/60%RH; accelerated 40°C/75%RH 90% 6 months. OOS investigation rate 0.06%; electronic batch records 21 CFR Part 11 compliant. DSC single endotherm 152°C confirms anhydrous Form I.​

Safety, Handling & Laboratory Precautions

Fume hood operations with polyethylene spatulas (static-free). PPE: nitrile gloves (BT>240 min), organic vapor half-mask, lab coat. GHS Acute Tox 4 H302, Skin Irrit 2 H315, Eye Irrit 2A H319. Spill protocol: diatomaceous earth absorption, 5% citric acid neutralization, Class II HEPA vacuum. Segregate from strong oxidizers (KMnO4, HNO3). DOT UN2810 PG III toxic solid organic. Est. LD50 580 mg/kg oral rat. SDS: mild dermal irritancy score 1.3 (reversible 72h). Thermal decomp >250°C liberates MeOH/NH3. Incinerate >1000°C hazardous waste protocol.​

Packaging, Labeling & Storage

1-50g quantities in amber screw-top vials (13 mm PTFE/silicone septa, nitrogen purged), secondary UN4G fiber drums with vermiculite. Labels conform to GHS/CLP: 3-MMA HCl, PGI VIII, corrosive pictogram, “Strictly Analytical Reagent.” Store desiccated 2-8°C (36 month expiry); post-opening monthly KF titration <0.5%, reseal under N2. IATA Packing Instruction 650 Category III air shipment.​

Intended Research Use & Market Positioning

Forensic GC-MS libraries (diagnostic 44/58 ions), NPS surveillance HRMS (180.138>133/91), chiral method validation (SFC Rs>3.0), clandestine synthesis byproduct profiling. Academic: regioselective phenolic methylation demonstrations. Complements 4-MA/PMMA/DOM analog panels; deuterated IS correction factor 1.02. CYP2D6 O/N-demethylation substrate studies. Prep-HPLC isolation >99% diastereopure.

Ordering, Availability & Fulfillment

Continuous WooCommerce inventory sync; PCI-DSS payments. Global DHL/FedEx Hazmat dispatch 24-72 hours, 99.8% on-time. Volume pricing tiers 100g+; instant COA QR download. Dedicated support for custom aliquots, stability data requests.​

Legal & Regulatory Disclaimer

This product is sold strictly for research purposes only. Not for human or veterinary use. Not for clinical, diagnostic, or consumptive applications. Buyers assume sole responsibility for compliance with all local, national, and international regulations governing research chemicals. Verify legal status prior to purchase.​