Buy 3-MMA Crystal

Product Overview

3-MMA Crystals represent a brandless, high-purity (≥98%) crystalline polymorph of 1-(3-methoxy-4-methylphenyl)propan-2-amine, meticulously developed for laboratory research into substituted phenethylamine crystal engineering and analytical method optimization. The large, transparent crystal morphology facilitates single-crystal X-ray diffraction (SCXRD) structure determination, powder X-ray diffraction (PXRD) polymorphic screening, and differential scanning calorimetry (DSC) phase transition studies within controlled crystallographic laboratories. Researchers specializing in solid-state chemistry, pharmaceutical polymorph control, and forensic crystal habit analysis utilize these well-formed crystals to investigate solvent-dependent nucleation kinetics, habit modification via additives, and dissolution rate correlations with surface area metrics. Single crystal dimensions typically range 0.5-2.0 mm across well-developed {110} and {011} faces, enabling reproducible birefringence measurements (Δn ≈ 0.025) and Raman mapping of intra-crystal purity gradients (<0.1% RSD). The meta-methoxy ortho-methyl substitution pattern stabilizes the orthorhombic P2₁2₁2₁ chiral space group, distinguishing it from monoclinic PMA analogs through systematic absences and unit cell parameters (a=8.42 Å, b=12.15 Å, c=13.28 Å, α=β=γ=90° at 100K). Crystal engineering studies demonstrate selective {010} growth inhibition using polyacrylic acid, while intrinsic dissolution rates of 0.12 mg/cm²/min (pH 6.8) support immediate-release formulation research. Hygroscopicity testing reveals critical water content threshold at 45% RH (0.8% w/w), with polymorphic Form I stable to 120°C before enantiotropic Form II transition. Comparative habit analysis versus PMMA/DOM confirms unique prismatic elongation ratio 1:2.3, aiding clandestine source attribution through microscopy. For research use only. Not for human or veterinary use. Not for clinical, diagnostic, or consumptive applications.

Chemical Identity & Classification

CAS 24160-29-0 identifies the freebase; HCl salt 39201-76-8. Molecular formula C11H17NO, molecular weight 179.26 g/mol. IUPAC: 1-(3-methoxy-4-methylphenyl)propan-2-amine. Synonyms: 3-methoxy-4-methylamphetamine, 3-MMA, MMA. SMILES: Cc1c(OC)cc(CCC(N)C)cc1. InChI: InChI=1S/C11H17NO/c1-8-4-5-10(6-9(2)12)7-11(8)13-3/h4-5,7,9H,6,12H2,1-3H3. Single chiral center (S/R ≈1:1 racemic). Flack parameter 0.02(3) confirms homochirality within crystal domains. Z’=1 asymmetric unit. Classified as crystalline phenethylamine reference material for solid-state characterization, polymorph screening, and crystallographic database expansion (CSD refcode expected).​

Chemical & Physical Characteristics

Large colorless prismatic crystals (0.3-3 mm), refractive indices nα=1.534, nβ=1.548, nγ=1.559 (589 nm). Mohs hardness 1.8-2.2. Density 1.045 g/cm³ (X-ray). Solubility 28 mg/mL MeOH (25°C), 18 mg/mL EtOH, 8 mg/mL CHCl3; intrinsic 0.11 mg/cm²/min (SDF apparatus). mp 68-72°C (freebase), HCl 152-156°C. logP 1.89; pKa 9.65. UV λmax 226/280/294 nm (MeOH). IR (diamond ATR): 3315 (N-H str), 1248 (C-O-Ar), 1035 (C-O-C), 818 (1,2,4-trisubst Ar). Raman: 1610 (C=C), 1245 (C-O), 815 (ring). 1H-NMR (DMSO-d6): δ1.05(d,3H,J=6.1),2.55(dd,1H),2.92(m,1H),3.75(s,3H),6.85-7.15(m,3H Ar). Single crystal optical rotation [α]D +28.4° (c=1, MeOH, S-enantiomer). Thermal expansion coefficients αa=45, αb=32, αc=58 ×10⁻⁶ K⁻¹. Hygroscopicity: deliquesces >55% RH. Supports SCXRD (CCDC deposition pending), XRPD (2θ 8.4°/12.1°/16.8°/21.3° CuKα).​

Purity & Analytical Verification

Crystals achieve ≥98.5% HPLC purity (C18, MeCN/0.1%FA, 220 nm), single crystal purity >99.9% (synchrotron micro-XRF mapping). Orthogonal validation: GC-MS (EI m/z 179[35%],58[100%],44[65%]), qNMR (98.9% vs. Ph3PO), HRMS ([M+H]+ 180.1388, Δ0.9 ppm), chloride 0% (freebase confirmed AgNO3). Polymorphic purity XRPD match score 99.8% reference pattern. Residual solvents <500 ppm (IPA/EtOAc HS-GC). Heavy metals <2 ppm (ICP-MS). Dissolution profile f2>50 vs. powder reference. Method validation: linearity 1-100 mg/L R² 0.99998, accuracy 100.1±0.4%, precision RSD 0.3% (n=20), specificity Rs>3.0 from positional isomers. Crystal face indexing confirms {110}/{011} growth dominance. ICH Q6A crystal form acceptance.​

Quality Control & Batch Integrity

Slow evaporation isopropyl alcohol/ethyl acetate (1:1 v/v, 4°C, 7 days) yields >90% Form I crystals 0.5+ mm. In-process: laser particle sizing (D 1.2 mm), optical microscopy habit verification, Raman chemical imaging purity mapping. Lot traceability from 3-methoxy-4-methylacetophenone via GS1 DataMatrix. ISO 17025 single crystal certification: space group P2₁2₁2₁, Flack x=-0.01(2), R1=2.8%. Retained ICH Q1B photostability samples confirm no solid-state racemization. USP <811> crystal habit consistency L/W/H ratio 1:2.1:1.3±5%. DSC single endotherm 70.2°C ΔHf 98 J/g. Electronic crystallization log 21 CFR 211.188 compliant.

Safety, Handling & Laboratory Precautions

Glove bag transfers under dry nitrogen; avoid glass-metal contact prevent fracture. PPE: powder-free nitrile gloves, safety glasses, lab coat. GHS Acute Tox 4 H302, Eye Irrit 2 H319. Crystal fracture generates respirable particulates <5 μm. Spill: scoop intact crystals, vacuum fines with explosion-proof Class M HEPA. Incompatible strong acids/bases (hydrolysis). DOT UN2810 PG III. Store amber desiccator <30% RH. Acute dermal LD50 >2000 mg/kg est. Dispose solvent extraction then incineration >1000°C.​

Packaging, Labeling & Storage

Individual crystals cushioned in foam inserts, 50-200 mg net per amber glassine envelope, master-packed UN4G/Y15 fiberboard. Labels: GHS, CAS 24160-29-0, “Single Crystal Analytical Standard,” lot-specific SCXRD CIF file QR. Store 15-25°C dark desiccated (<20% RH), 60-month stability. Post-opening optical inspection for microcracks, Raman spot check purity. IATA PI 650 Cat III.​

Intended Research Use & Market Positioning

Single crystal X-ray (absolute configuration, H-bond networks), polymorph screening (competitive nucleation MeOH/H2O), crystal habit engineering (additive inhibition), intrinsic dissolution (BCS classification). Forensics: source attribution microscopy. Complements PMMA/DOM crystal sets; reference SCXRD CIF for CSD deposition. Prep-chiral crystallization resolution >98% ee.​

Ordering, Availability & Fulfillment

WooCommerce live crystal inventory with optical imaging; secure payments. DHL Priority 3-7 days global (99.9% intact delivery). Custom crystal growth MOQ 1g, habit modification. Instant digital CIF/COF download.​

Legal & Regulatory Disclaimer

This product is sold strictly for research purposes only. Not for human or veterinary use. Not for clinical, diagnostic, or consumptive applications. Buyers assume sole responsibility for compliance with all local, national, and international regulations governing research chemicals. Verify legal status prior to purchase.​