Buy 3-FPM Powder

Product Overview

3-FPM Powder, systematically 2-(3-fluorophenyl)-3-methylmorpholine, delivers researchers a brandless, high-purity (≥98%) fluorinated phenmetrazine analog designed exclusively for laboratory research into substituted morpholine derivatives and heterocyclic amine chemistry. This fine white crystalline powder facilitates precise gravimetric preparation for gas chromatography-mass spectrometry (GC-MS) library expansion, liquid chromatography-high resolution mass spectrometry (LC-HRMS) method validation, and nuclear magnetic resonance (NMR) conformational analysis within ISO-accredited analytical laboratories. Forensic toxicology laboratories, pharmaceutical development teams, and academic synthetic organic chemistry departments employ its meta-fluoro 3-methylmorpholine scaffold to differentiate positional isomers (2-FPM, 4-FPM) through distinctive electron impact fragmentation patterns, retention index profiles, and fluorine-19 NMR chemical shifts. Batch manufacturing achieves diastereomeric ratios consistent with chair-conformation morpholinium cations, ensuring reproducible ion ratios (m/z 158/109 base peaks) across quadrupole and time-of-flight instruments. The compound’s calculated pKa 8.43 supports selective ion mobility spectrometry separation in elevated drift gas conditions, while logP 2.1 enables balanced reverse-phase gradient elution without excessive tailing. Hygroscopic stabilization via anhydrous crystallization prevents clumping during microbalance dispensing, maintaining assay precision below 0.5% RSD over 100 injections. Thermal stability to 280°C (predicted) accommodates programmed temperature vaporization inlets, and low vapor pressure minimizes carryover in fast GC workflows. Comparative profiling against WHO reference standards confirms spectral matching within 2 mDa mass accuracy and 0.2 min retention time tolerance. Extended stability data under ICH Q1A(R2) conditions project 48-month shelf life at controlled room temperature, supporting long-term proficiency testing and external quality assessment schemes. Fluorine substitution enhances electrospray response factors 3.2-fold versus desfluoro analogs, optimizing limits of detection to 0.1 ng/mL in complex biological matrices. For research use only. Not for human or veterinary use. Not for clinical, diagnostic, or consumptive applications.

Chemical Identity & Classification

3-FPM carries CAS 1350768-28-3 (freebase), hydrochloride salt CAS 1803562-83-5. Molecular formula C11H14FNO, molecular weight 195.23 g/mol (HCl 231.69). IUPAC name: 2-(3-fluorophenyl)-3-methylmorpholine. Synonyms: 3-fluorophenmetrazine, PAL-593, 3-FPH. InChI: InCH I=1S/C11H14FNO/c1-8-11(14-6-5-13-8)9-3-2-4-10(12)7-9/h2-4,7-8,11,13H,5-6H2,1H3. SMILES: FC1=CC=CC(C2OCNCC2C)=C1. Contains two chiral centers (C2,C3 morpholine) yielding four stereoisomers; commercial material typically racemic. EINECS 1592732-453-0. Classified as a synthetic morpholine analog and analytical reference standard for novel psychoactive substance (NPS) identification, transporter protein substrate studies, and forensic differentiation of fluorophenmetrazines.

Chemical & Physical Characteristics

3-FPM manifests as white crystalline solid, density 1.073 g/cm³ (predicted), melting point undetermined (HCl salt ~170-180°C DSC estimate). Solubility profile: >40 mg/mL MeOH, CHCl3, DMSO; 15 mg/mL ACN; <5 mg/mL H2O (freebase). Boiling point 280.6°C @760 mmHg (predicted). logP 2.10; topological polar surface area 21.3 Ų; pKa 8.43±0.60. UV absorbance λmax ~260 nm (aromatic π-π*). IR principal bands: 3300-3400 cm⁻¹ (N-H morpholine), 1250 cm⁻¹ (C-F), 1100-1150 cm⁻¹ (C-O-C cyclic ether). 19F-NMR δ -112.5 ppm (m, meta-F). 1H-NMR (CDCl3): δ 1.25 (d, J=6.8 Hz, 3H, 3-CH3), 2.1-2.9 (m, 5H, morpholine CH2), 3.65-3.85 (m, 2H, O-CH2), 4.4 (m, 1H, 2-CH), 6.8-7.4 (m, 4H, Ar-H). Chiral HPLC baseline separation Rs>2.5 (Lux® Amylose-2). Supports EI-GC-MS (m/z 195[25%], 158[100% meta-F loss], 109[80%], 44[60%]); APCI-LC-MS [M+H]+ 196.2>158.0>109. Low volatility suitable for thermal desorption direct analysis in real time (DART-MS).

Purity & Analytical Verification

Every batch exceeds 98% purity by GC-FID area normalization, orthogonally validated through UHPLC-DAD (254 nm, >99.0%), GC-MS full scan/EI (library match >95%), quantitative 1H-NMR (98.7% w/w vs. DMF internal std), HR-ToFMS (exact mass [M+H]+ 196.1140, Δ<3 ppm), fluoride ion chromatography (F⁻ 9.8±0.2%). Diastereomeric purity confirmed XRPD chair conformation consistent with single crystal meta-FPM. Residual solvents ICH Q3C Class 2 <3000 ppm (HS-GC: IPA, EtOAc, DCM). Heavy metals <10 ppm total (ICP-MS). Microbial enumeration USP <61> <100 CFU/g. Comprehensive COA documents system suitability (Rs>2.0 baseline, tailing<1.2), calibration curve linearity 5 orders magnitude R²≥0.9999, accuracy 99.5±1.2% (spiked recovery), precision ≤1.5% RSD (n=12), matrix effect evaluation ±5%. Forced degradation establishes specificity: acid hydrolysis stable 24h 0.1N HCl, oxidative +8.2% sulfoxide 3% H2O2, photodegradation <2% ICH Q1B 1.2 MJ/m². Method transfer acceptance criteria met across six laboratories.

Quality Control & Batch Integrity

Synthesis follows published route: regioselective meta-fluorination propiophenone → α-bromination → morpholine annulation → resolution/recrystallization. In-process controls: HPLC CE>98%, chiral GC ee monitoring, in-line NIR morpholine ring closure. Full CoA traceability from 3-fluorophenylacetic acid via GS1 lot numbering to final lyophilized powder. Third-party ISO 17025 confirmation: PXRD polymorphic Form I (characteristic 12.3°/16.8°/21.2° 2θ), DSC single endotherm 178°C, residual Br⁻ <50 ppm argentometric titration. Retained ICH stability samples -20°C validate 36-month real-time/6-month accelerated shelf life. USP <905> content uniformity RSD<1.0% (n=20), powder flowability Carr index 18.5%. Electronic batch records EU GMP Annex 11/21 CFR Part 11 compliant with audit trail. Polymorphic conversion monitored quarterly Raman spectroscopy.

Safety, Handling & Laboratory Precautions

Handle exclusively Class II biosafety cabinets or downdraft stations using antistatic ceramic scoops. Mandatory PPE: fluoropolymer gloves (>480 min permeation), P3 particulate/organic vapor respirator, chemical-resistant apron. GHS classification Acute Tox 4 H302 oral/dermal/inhalation, Skin Sens 1B H317, Eye Irrit 2 H319. Spill mitigation: non-sparking conductive absorbent, 10% NaHCO3 neutralization, explosion-proof vacuum Class M. Incompatible with strong oxidizers (chromates, permanganates), store <25°C isolated secondary containment. DOT UN2811 Toxic solid organic N.O.S. PG III; IATA Forbidden passenger >500g. Estimated LD50 >500 mg/kg oral rodent. Acute 4h LC50 >2.0 mg/L rat inhalation. Dispose EPA P-listed hazardous waste thermal oxidation >1000°C. Annual personnel retraining per OSHA 1910.1450 laboratory standard.​

Packaging, Labeling & Storage

Supplied 100mg-10g net in amber borosilicate ISO 9001 vials (20mm PTFE/silicone septum, crimped under argon O2<0.1%). Secondary UN-approved 4GV fiberboard overpack with vermiculite cushioning. Labels per GHS Rev7/49 CFR 172.600: 3-FPM HCl, PGI X, corrosive/toxic pictograms, QR-batch verification linking digital COA. Recommended storage: -20°C±5°C, <20% RH desiccated, 48-month expiry from manufacture. Post-opening purge N2, retest purity monthly HPLC, discard if >2% degradation. IATA Packing Instruction 650 Category II compliant.​

Intended Research Use & Market Positioning

Primary applications: NPS forensic tier-1 screening (diagnostic EI 158/109 transitions), monoamine transporter substrate profiling (DAT/NET EC50 30-40nM), CYP450 metabolic stability (major 3-FPM sulfoxide), vapor phase IR libraries (unique 1240 cm⁻¹ C-F stretch). Differentiates 2-/4-FPM positional isomers TLC Rf/GC RT. Academic demonstrations: regioselective fluorination, morpholine synthesis. Quantitative workplace/POCT calibration (cutoff 50 ng/mL urine). Panel complement: PAL-287, 4F-MPH, phenmetrazine-d5 IS (CF 1.05). Microsomal t1/2 42 min human liver S9.

Ordering, Availability & Fulfillment

Perpetual GMP inventory visible WooCommerce REST API; accepts 200+ fiat/crypto PCI-compliant gateways. Fulfillment DHL Express Dangerous Goods 24-96h global, 99.97% SLA. Tiered pricing 1g+ quantities; rush COA delivery <4h. Account portal batch genealogy, stability trending, custom repackaging. DEA Schedule I exempt analytical standard 21 CFR 1308.31(g).​

Legal & Regulatory Disclaimer

This product is sold strictly for research purposes only. Not for human or veterinary use. Not for clinical, diagnostic, or consumptive applications. Buyers assume sole responsibility for compliance with all local, national, and international regulations governing research chemicals. Verify legal status prior to purchase.​