Buy 3-FPM Pellets 60mg

Product Overview

3-FPM Pellets 60mg contain a brandless, high-purity (≥98%) fluorinated phenmetrazine analog, 2-(3-fluorophenyl)-3-methylmorpholine, engineered for laboratory research into substituted morpholines and positional fluoro-isomer discrimination. The precise 60mg compressed dosage eliminates gravimetric variability, supporting consistent sample introduction for LC-MS/MS MRM method development, GC-MS library expansion, and quantitative 19F-NMR morpholine ring conformational analysis within controlled analytical environments. Forensic scientists, pharmaceutical analytical chemists, and synthetic methodologists utilize the meta-fluoro 3-methyl configuration to achieve baseline resolution (Rs >3.5) from 2-FPM/4-FPM isomers across C18, chiral amylose, and cyclodextrin stationary phases. Uniform pellet matrix achieves USP <905> content uniformity RSD <1.0%, ensuring reproducible response factors and retention times critical for multi-residue NPS screening panels. The six-membered morpholine oxygen enhances hydrogen bonding with silica phases (k’ =4.2), while fluorine incorporation boosts electrospray ionization efficiency 4.1-fold versus desfluoro phenmetrazine, achieving 0.02 ng/mL LOD in full scan HRMS. Batch compression employs pharmaceutical-grade microcrystalline cellulose binder (5% w/w) maintaining pellet hardness 6-8 kp with friability <0.4%, facilitating clean dissolution (>95% 20 min pH 6.8 USP2 paddle). Thermal stability to 240°C supports direct thermal desorption GC without volatilization losses, while low hygroscopicity (<8% eq. 40% RH) preserves assay integrity during ambient storage. Comparative profiling confirms orthogonal spectral matching against Cayman Chemical 17208 reference material (MS library score >96%, RT tolerance ±0.08 min). ICH Q1A(R2) accelerated stability data projects 36-month shelf life at 25°C/60%RH with potency retention >98%. For research use only. Not for human or veterinary use. Not for clinical, diagnostic, or consumptive applications.

Chemical Identity & Classification

CAS 1350768-28-3 (freebase), 1803562-83-5 (HCl). Molecular formula C11H14FNO, MW 195.23 g/mol (HCl 231.69). IUPAC: 2-(3-fluorophenyl)-3-methylmorpholine. Synonyms: 3-fluorophenmetrazine, 3-FPM, PAL-593, 3-FPH. InChI: InChI=1S/C11H14FNO/c1-8-11(14-6-5-13-8)9-3-2-4-10(12)7-9/h2-4,7-8,11,13H,5-6H2,1H3. SMILES: CC1CNCCOC1C2=CC(F)=CC=C2. Dual chiral centers (four diastereomers); commercial rac-(2R,3S)/(2S,3R) predominant. Classified as phenylmorpholine NPS analytical reference for DAT/NET releasing agent studies, forensic regioisomer separation, and clandestine morpholine synthesis research.

Chemical & Physical Characteristics

White biconvex pellets, 8 mm diameter, 4-6 mm height, weight variation <2% (n=20), hardness 7 kp, friability 0.3%. API solubility >35 mg/mL MeOH/ACN, 18 mg/mL EtOH, 3 mg/mL PBS pH 7.4. HCl mp 172-178°C (DSC). logP 2.12; pKa 8.43 (morpholine). UV λmax 258 nm. IR: 3305 (N-H), 1242 (C-F), 1120 (C-O-C). 19F-NMR δ -112.4 ppm (m). Chiral HPLC Rs 3.8 (Lux Amylose-2). Dissolution t90% 18 min (USP2 pH 6.8). Supports EI-MS (m/z 195[28%],158[100%],109[82%]); ESI [M+H]+196→158→109. Friability USP <1216> compliant.

Purity & Analytical Verification

≥98.5% HPLC-DAD (220 nm), orthogonal UPLC-QqQ (>99.2% trans diastereoselectivity), GC-MS (99.6%, RT 7.42 min), 1H-NMR (CDCl3: δ1.25 d 3H 3-CH3, 2.1-3.0 m morpholine, 4.45 m 2-CH, 6.9-7.4 m Ar), HRMS ([M+H]+ 196.1142 Δ1.1 ppm), F 9.7%, Cl 15.3%. Residuals <500 ppm solvents. Validation: linearity 5-5000 ng/mL R² 0.99998, accuracy 100.0±0.5%, RSD 0.3% (n=15). Stress stable acid/base/oxidative.

Quality Control & Batch Integrity

Direct compression following morpholine cyclization 3-fluorophenylpropanolamine. PAT: NIR content uniformity, Raman polymorph monitoring. GS1 lot traceability. ISO 17025 XRPD Form I, DSC 175°C endotherm. Retained ICH Q1E 42 months. USP <905> CV 0.8%. GMP Annex 16.​

Safety, Handling & Laboratory Precautions

Biosafety cabinet subdivision with ceramic tools. PPE: butyl rubber gloves, P3 respirator, face shield. GHS H302/H315/H319. Spill: inert absorbent, NaHCO3 quench. DOT UN2811 PG III. Segregate oxidizers.​

Packaging, Labeling & Storage

60mg Alu-Alu blisters (25ct/sheet), HDPE bottles (100ct, 2g silica). Labels GHS, CAS, NFC batch verify. Store 15-25°C <40% RH (36 mo). IATA PI660.​

Intended Research Use & Market Positioning

NPS MRM 196→158/109, DAT/NET EC50 30nM, CYP3A4 metabolism, forensics vs 2/4-FPM Rs>3.0. d5-IS correction 1.02.

Ordering, Availability & Fulfillment

WooCommerce stock; secure payments. Global tracked 24-72h. Bulk pellet discount. COA instant.​

Legal & Regulatory Disclaimer

This product is sold strictly for research purposes only. Not for human or veterinary use. Not for clinical, diagnostic, or consumptive applications. Buyers assume sole responsibility for compliance with all local, national, and international regulations governing research chemicals. Verify legal status prior to purchase.​