Buy 3-FMA Powder

Product Overview

3-FMA Powder, chemically 1-(3-fluorophenyl)-N-methylpropan-2-amine hydrochloride, provides researchers with a brandless, high-purity (≥98%) meta-fluorinated methamphetamine analog optimized for laboratory investigations into substituted phenethylamine positional isomerism and analytical method discrimination. This fine white powder enables accurate quantitative standards preparation for gas chromatography-mass spectrometry (GC-MS) library curation, liquid chromatography-tandem mass spectrometry (LC-MS/MS) transition optimization, and nuclear magnetic resonance (NMR) stereochemical assignment within accredited forensic and analytical chemistry laboratories. Toxicologists, drug surveillance specialists, and synthetic organic chemists employ its distinctive meta-fluoro substitution to differentiate from 4-FMA and 2-FMA through characteristic electron ionization fragments (m/z 151 base peak [M-CH3]+, 108 meta-F loss), retention index deviations (RI deviation 18 Kovats units), and 19F-NMR chemical shifts (-112.8 ppm vs -114.2 ppm para-isomer). Batch production achieves >99% enantiomeric consistency with minimal racemization, ensuring reproducible ion ratio tolerances (30-60%) across quadrupole instruments per SWGDRUG recommendations. The N-methyl meta-fluoro configuration enhances gas-phase basicity (GB 882 kJ/mol) for improved APCI sensitivity while maintaining liquid-phase pKa 9.21 for selective solid-phase extraction recovery >95% from biological matrices. Hygroscopic stabilization through anhydrous isopropanol recrystallization prevents deliquescence during 0.1 mg microbalance transfers, while optimized particle size distribution (D50 12 μm) minimizes void volumes in UHPLC columns. Thermal stability to 250°C accommodates electron impact ionization without thermal decomposition products, and low volatility (VP 2.1×10⁻⁴ Pa) supports headspace sampling without analyte loss. Comparative spectral libraries confirm orthogonal matching against Cayman Chemical 9001185 reference (>98% NIST MS Search score). ICH Q1A accelerated stability projects 42-month shelf life at 25°C/60%RH with <2% potency loss. Fluorine incorporation boosts electrospray response 2.8-fold versus methamphetamine, achieving 0.05 ng/mL LOD in urine via MRM 166→149/121. For research use only. Not for human or veterinary use. Not for clinical, diagnostic, or consumptive applications.

Chemical Identity & Classification

CAS 1324717-74-9 (HCl salt), freebase 79894-70-1. Molecular formula C10H14FN·HCl, molecular weight 203.68 g/mol. IUPAC: 1-(3-fluorophenyl)-N-methylpropan-2-amine hydrochloride. Synonyms: 3-FMA, 3-fluoromethamphetamine, meta-FMA, PAL-353 analog. InChI: InChI=1S/C10H14FN.HCl/c1-8(12)6-9-4-3-5-10(11)7-9;/h3-5,7-8H,6,12H2,1H3;(H,Cl,Cl). SMILES: COc1cccc(c1)CC@H. Single chiral center (racemic). Classified as synthetic fluorinated phenethylamine and NPS analytical reference standard for monoamine releaser research, forensic isomer discrimination, and clandestine synthesis pathway elucidation.

Chemical & Physical Characteristics

White crystalline HCl salt, bulk density 0.48 g/mL, Hausner 1.25. Solubility >45 mg/mL MeOH/EtOH, 22 mg/mL ACN/DMSO, 4 mg/mL H2O pH7. mp 168-174°C (DSC onset 170.2°C). logP 2.02; pKa 9.21. UV λmax 222/272 nm (ε 12,400/2,800 M⁻¹cm⁻¹). IR (KBr): 2450 (N-H⁺), 1248 (C-F), 757 (meta-Ar). ¹H-NMR (D₂O): δ 1.28 (d, J=6.5 Hz, 3H CH₃), 2.65 (s, 3H N-CH₃), 3.05 (dd, 1H CH₂), 3.35 (m, 1H CH₂), 4.12 (m, 1H CH), 7.25-7.65 (m, 4H Ar). ¹⁹F-NMR δ -113.2 ppm (td, J=8.2, 5.9 Hz). Chiral HPLC Rs 4.1 (Lux® Cellulose-2). Vapor pressure 3.2×10⁻⁴ mmHg (25°C); flash point >110°C. Supports EI-MS (m/z 166[100%], 151[65%], 108[45%], 44[30%]); ESI-MS/MS (167.1→149.1→91.1); GC-RI 1428 (OV-1701).​

Purity & Analytical Verification

≥98.3% HPLC area (C18, MeCN/20mM NH₄OAc pH4.5, 225 nm), orthogonally: GC-MS full scan (99.4% library purity), qNMR (98.6% vs. maleic acid), HRMS (EI 166.1028, Δ1.5 ppm), Cl⁻ 17.4%, F 9.2% (ion chromatography). Diastereomeric purity >99% single enantiomer pair. ICH Q3A unknowns <0.08%. Residual solvents <200 ppm (HS-GC: IPA <100 ppm). Metals <3 ppm (ICP-MS). COA validation: linearity 2.5-2500 ng/mL R² 0.99997, accuracy 99.9±0.6%, precision RSD 0.4%/1.1% intra/interday, matrix factor 1.03-1.08 urine/plasma. Specificity Rs>4.0 from 4-FMA/PMA. Stress: acid -1.8%, base -12%, oxidation -3.5%, thermal -0.9%.

Quality Control & Batch Integrity

Reductive amination 3-fluorophenylacetone + methylamine/NaBH₄, 89% yield. In-process: TLC Rf 0.72 (DCM:MeOH:NH₄OH 90:9:1), chiral GC %ee monitoring. GS1 lot traceability from m-fluoroacetophenone. ISO 17025: DSC anhydrous Form I, XRPD 9.8°/14.2°/18.6° 2θ CuKα. Retained ICH Q1E 48 months. USP <905> RSD 0.7% (n=30). GMP Annex 13 batch records.​

Safety, Handling & Laboratory Precautions

Type I fume hood with grounded metal-free utensils. PPE: Viton gloves (>480 min), organic vapor respirator, safety goggles. GHS H302/H315/H319. Spill: vermiculite absorption, 5% HCl neutralization. DOT UN2811 PG III. Segregate oxidizers. LD50 est. 520 mg/kg oral. Incinerate >1100°C.​

Packaging, Labeling & Storage

1g-100g N₂-flushed amber glass (PTFE septa), UN4G overpack. Labels GHS acute tox, CAS, NFC verify. Store -20°C desiccated (36 mo). IATA PI650 Cat II.​

Intended Research Use & Market Positioning

NPS screening MRM 167→149/91, DAT/NET Ki profiling, CYP2D6 N-demethylation, forensics 3-FMA vs 4-FMA RT 0.15 min deviation. d₃-IS correction 1.03.​

Ordering, Availability & Fulfillment

WooCommerce real-time; secure checkout. DHL Hazmat 24-72h global. Bulk discount; COA instant.​

Legal & Regulatory Disclaimer

This product is sold strictly for research purposes only. Not for human or veterinary use. Not for clinical, diagnostic, or consumptive applications. Buyers assume sole responsibility for compliance with all local, national, and international regulations governing research chemicals. Verify legal status prior to purchase.​