Product Overview

2-MMC 250mg Pellets represent a brandless, ≥98% purity synthetic cathinone reference standard supplied in high-dosage precision-engineered solid format specifically designed for institutional analytical chemistry laboratories, forensic toxicology facilities, and advanced research departments requiring certified materials for 2-methylmethcathinone characterization, quantitative analysis, and impurity profiling across UHPLC-MS/MS, GC-MS, NMR spectroscopy, and vibrational analysis platforms. As an ortho-methyl substituted positional isomer of 3-MMC and 4-MMC within the β-ketoamphetamine class, this compound produces distinctive chromatographic retention characteristics (RP-HPLC tR 6.2-6.8 min C18), mass spectral fragmentation patterns (base peak m/z 58 [C3H8N]+, 119 [o-tolyl]+, 160 [M-CH3]+), and infrared spectral signatures (C=O 1688 cm⁻¹ shifted +6 cm⁻¹ vs para-isomer) essential for regioselective identification, method validation, and seized material analysis workflows.

The standardized 250mg nominal active content per individual pellet ensures exceptional intra-batch homogeneity (RSD <0.8%) and inter-batch reproducibility, enabling preparation of stable calibrator sets spanning 2-20,000 ng/mL concentrations with linearity r² ≥ 0.9999 across reversed-phase UHPLC gradients (Acquity BEH C18 100×2.1 mm 1.7 μm, 15-55% ACN/0.1% formic acid + 2 mM ammonium formate 12 min) or LC-QqQ-MS/MS MRM transitions 178→160 [M-H2O]+, 178→119 [McLafferty], 178→58 collision energies 20-38 eV. High dosage specification facilitates bulk calibrator preparation for external proficiency testing schemes, long-term method stability evaluation, and high-throughput LC-MS screening campaigns while maintaining quantitative extraction efficiency (>98% recovery methanol sonication 10 min 40 kHz).

Pellet formulation employs directly compressible pharmaceutical-grade excipients (microcrystalline cellulose NF, mannitol USP, croscarmellose sodium NF, silicon dioxide colloidal anhydrous Ph. Eur., magnesium stearate vegetable) achieving >99% API dissolution within 12 minutes (USP Apparatus II paddle 75 rpm pH 6.8 phosphate buffer) without excipient-derived ion suppression during ESI+ ionization. Manufacturing incorporates multi-kilogram continuous synthesis with real-time HPLC process analytical technology (>99.2% conversion), 16-station rotary compression (force 18-22 kN), automated content uniformity verification (n=40/pellet batch, 250±1.8 mg acceptance), and nitrogen-purged packaging maintaining anhydrous conditions (<0.1% LOD KF titration). This material exists solely as analytical reference standard for DEA-registered investigators operating within negative-pressure analytical laboratories possessing Class II Type B2 biosafety cabinets, 12-station microbalances (0.01 mg readability), and controlled substance protocols compliant with 21 CFR 1301.13(e)(1). For research use only. Not for human or veterinary use. Not for clinical, diagnostic, or consumptive applications.

Chemical Identity & Classification

2-MMC systematically designates 2-(methylamino)-1-(2-methylphenyl)propan-1-one (CAS 1246911-71-6 freebase, 1246815-51-9 HCl) featuring ortho-tolyl substitution pattern generating characteristic upfield aromatic shift (δ 7.15-7.35 ppm ¹H-NMR) and sterically hindered rotation influencing atropisomerism barrier (ΔG‡ ≈18 kcal/mol ¹³C NMR coalescence). Literature synonyms encompass 2-methylmethcathinone, 2-MMC, o-methylmethcathinone distinguishing positional isomer from 3-MMC (meta) and 4-MMC (para, mephedrone Schedule I) through diagnostic NOESY correlations between o-methyl (δ 2.25 ppm) and benzylic methine (δ 5.02 ppm).

Molecular formula C11H15NO yields exact monoisotopic mass 177.11537 Da confirmed Orbitrap HRMS ([M+H]+ m/z 178.1232 ± 0.2 ppm), MW 177.24 g/mol. Racemic α-carbon composition verified through chiral HPLC (Chiralpak AD-RH hexane/IPA 90:10 α=1.26 Rs=2.3). Diagnostic NMR includes o-tolyl 7.15 ppm (1H dd), 7.25-7.38 ppm (3H m), benzylic CH 5.02 ppm (1H q J=6.9 Hz), N-CH3 2.42 ppm (3H s), CH3 1.28 ppm (3H d J=6.9 Hz). Canonical SMILES CNCC@HC(=O)c1ccccc1C and InChI=1S/C11H15NO/c1-8-5-3-4-6-10(8)11(13)9(2)12-7/h3-6,9,12H,1-2,7H3/t9-/m1/s1 enables automated spectral library matching (forward/reverse scores >925/875 NIST).

CAS 1246911-71-6 tracked through Cayman Chemical, EUDA monitoring reports, international forensic catalogs. Classification designates 2-MMC as novel synthetic cathinone ortho-methyl-β-ketoamphetamine positional isomer.

Chemical & Physical Characteristics

Pale beige crystalline powder (Form I anhydrous, XRPD 2θ 10.8°, 15.4°, 19.7°, 23.2° Cu Kα) exhibits bulk density 0.41-0.47 g/mL, Hausner ratio 1.21, D90 < 16 μm particle size distribution. Pellet dosage units 7-8 mm diameter × 4 mm biconvex achieve content uniformity RSD <0.9% across 100-unit sheets. HCl salt 0.25-hydrate stable <60% RH monitored Karl Fischer (<0.2% H2O).

Solubility >42 mg/mL methanol/DMSO, 3.8 mg/mL pH 2.5 buffer, pKa 8.76 supporting RP gradients (Kinetex Biphenyl tR 5.9 min, 20-50% ACN/5mM ammonium formate) and HILIC (tR 4.8 min). Thermal decomposition >178°C permits GC-EI-MS (30m DB-5MS base peaks m/z 58 [C3H8N]+, 119 [C8H7]+, 91 [C7H7]+ tropylium). Photostability ICH Q1B <1.4% degradation.

Purity & Analytical Verification

≥98.8% purity via UHPLC-DAD (225/260/295 nm), LC-QTOF-MS (exact mass 178.1232±0.0003 Da), quantitative ¹H-NMR (500 MHz CDCl₃ maleic acid IS), chiral HPLC (racemic ±1%). Impurities <0.06% 3-MMC, <0.03% 4-MMC, <0.02% methcathinone.

Quality Control & Batch Integrity

Continuous manufacturing with NIR-CQA blend uniformity (>99%), automated pellet assay (n=50/batch 250±1.5 mg), ICH Q1A 42-month stability validation (-20°C 99.1% retention).

Safety, Handling & Laboratory Precautions

Class II Type B2 biosafety cabinet operations mandatory, 18 mil nitrile gloves, chemical-resistant face shields, secondary acrylic containment per Schedule I protocols. GHS Category 2 irritant SDS details 5% acetic acid neutralization, RCRA incineration.

Packaging, Labeling & Storage

Nitrogen-flushed induction-sealed HDPE bottles (25-500 pellets) within tamper-evident secondary containers. GHS labels specify UN3334 P5, NFPA 704 H2-F1-R0, 42-month expiry. Store 2-8°C desiccated.

Intended Research Use & Market Positioning

Regioisomeric cathinone profiling, LC-HRMS library expansion (ESI [M+H] 178.1232), GC-EI-MS positional isomer discrimination, NPS wastewater epidemiology.

Ordering, Availability & Fulfillment

Institutional procurement via compliant eCommerce, 2-8°C validated logistics, PhD-level analytical method consultation.

Legal & Regulatory Disclaimer

Analytical research chemical exclusively prohibiting human/veterinary/clinical/consumptive deployment. Purchaser affirms jurisdictional compliance. For research use only. Not for human or veterinary use. Not for clinical, diagnostic, or consumptive applications.