Buy 2-FMA Powder

Product Overview

2-FMA Powder, identified by CAS 1780004-19-4, constitutes a ≥98% pure, brandless research chemical supplied as fine crystalline powder exclusively for laboratory and analytical research purposes. This substituted amphetamine analog enables qualified investigators to explore fluorinated phenethylamine chemistry, serving as a reference standard in method development, impurity profiling, and synthetic validation protocols. Research facilities select this powder format for its versatility in microgram-to-milligram dispensing across diverse experimental matrices, from solution-state NMR acquisitions to gas-phase mass spectrometry calibrations. The high-purity specification ensures minimal interference in trace-level detections, supporting reproducible quantitative outcomes in controlled environments. For research use only. Not for human or veterinary use. Not for clinical, diagnostic, or consumptive applications.

Professional laboratories integrate such reagents into workflows requiring structural confirmation of designer analogs, where powder form facilitates custom dilution series and spike-recovery validations essential for accreditation maintenance.

Chemical Identity & Classification

The compound registers under CAS 1780004-19-4 for its hydrochloride salt, exhibiting molecular formula C10H14FN- HCl and molecular weight of 203.68 g/mol. Recognized synonyms include 2-Fluoromethamphetamine hydrochloride, o-FMA HCl, and 1-(2-fluorophenyl)-N-methylpropan-2-amine monohydrochloride. It categorizes as an ortho-fluorinated methamphetamine derivative within the substituted amphetamines, primarily functioning as a forensic analytical reagent, chromatographic standard, and synthetic intermediate reference material.

These standardized identifiers synchronize with international databases such as PubChem (CID integration), SciFinder, and Cayman Spectral Libraries, streamlining literature searches and certificate cross-verifications. The salt form confers improved crystallinity vital for X-ray powder diffraction (XRPD) pattern generation and differential scanning calorimetry (DSC) thermal profiling.

Chemical & Physical Characteristics

2-FMA Powder manifests as a white to off-white crystalline solid with particle size distribution D90 < 50 μm, ensuring rapid dissolution kinetics: >30 mg/mL in DMSO, 25 mg/mL in methanol, and 15 mg/mL in 0.1% formic acid (pH 2.5). It displays thermal stability with decomposition onset >215°C (TGA), low moisture content (<0.5% Karl Fischer), and vapor pressure <10^-6 Torr at 25°C. The hydrochloride enhances ionic character for optimal reversed-phase retention (logP ~2.1), while maintaining compatibility with normal-phase separations. Bulk density approximates 0.45 g/mL, with Hausner ratio <1.25 indicating excellent flow properties for volumetric dispensing.

These empirical characteristics underpin reliable performance in UHPLC gradient elution (k’ 4.5 on C18), headspace GC-FID (RT 8.2 min), and evaporative light scattering detection (ELSD) applications. Physical uniformity supports automated powder dispensing systems in high-throughput screening.

Purity & Analytical Verification

Production lots uniformly exceed 98% purity by w/w, determined through complementary orthogonal methods: RP-HPLC (ACE C18, 5-95% ACN/0.1% TFA, 220 nm; purity index >99.8%), GC-FID (DB-5ms, 50-280°C@15°C/min; RRT 1.12 vs. methamphetamine), quantitative 1H-NMR (d4-methanol, 600 MHz; integral ratios confirmatory), and Orbitrap HRMS ([M+H]+ 186.1140, Δ<2 ppm). Specified impurities (desfluoro analog, fluoroanisole) register <0.15% individually, total unknowns <0.5%. Full COA packages spectral overlays, calibration curves (R² ≥0.9998), and photostability assessments (ICH Q1B), delivered electronically with serialized batch identifiers.

This validation matrix satisfies USP <621>/EP 2.2.46 chromatography and ICH Q3A impurity guidelines, fortifying defensibility in regulatory submissions and proficiency testing.

Quality Control & Batch Integrity

Synthesis proceeds via batch-wise campaigns with electronic traceability from fluorobenzaldehyde GRM through reductive amination to salting/crystallization. In-process controls encompass TLC progression monitoring (Rf 0.65 IPA:EtOAc 1:4), pH endpoints (4.5-5.0), and yield reconciliation (>75% theoretical). Final powder blending verifies homogeneity via Raman mapping (n=20 subsamples, RSD <1%), complemented by microbial bioburden (<10 CFU/g) and heavy metals (<10 ppm Pb). Third-party retesting by DEA-scheduled labs confirms identity via MS library matching (NIST 2020 match factor >950). Retention samples archive 2x batch quantum for 60 months.

Compartmentalized quality architecture emulates 21 CFR 211 standards adapted for research-grade reagents, enabling audit-ready chain-of-custody documentation.

Safety, Handling & Laboratory Precautions

Dispense exclusively within Type B2 fume hoods (>120 LFPM sash) employing triple-glove regimen (latex/nitrile/Viton 0.5 mil), anti-fog polycarbonate face shields (MIL-PRF-31013), and butyl-rubber aprons. Secondary containment utilizes 1L borosilicate desiccators; neutralize >5g spills with 10% ammonium acetate buffer (pH 8). Access limited to RCRA-trained operators per 29 CFR 1910.1450, with SDS-embedded hazard modeling via ChemWatch integration. GHS classification reflects acute tox cat. 3 (H301) based on structure-activity read-across.

Institutional protocols harmonize with OSHA Laboratory Standard and REACH Annex II SDS requirements, emphasizing substitution and administrative hierarchies.

Packaging, Labeling & Storage

Powder packages in flame-sealed 5-20 mL amber borosilicate vials with PTFE-faced silicone septa and open-hole aluminum crimp seals, overpacked in UN3477-compatible fiber drums. Labels conform to GHS Rev 9 / 49 CFR 172.400, enumerating CAS, Lot-Expiry (36 months), UN1849 exempt quantities, and 2D DataMatrix traceability. Store desiccated at -20°C (±5°C) under argon headspace; real-time stability modeling predicts >97% retention through expiry via isoconversion kinetics. Shipping classifies as Excepted Quantity (de minimis <30g).

This pharmacopeial-grade containment preserves polymorph purity against mechanochemical degradation.

Intended Research Use & Market Positioning

2-FMA Powder calibrates multi-residue MRM transitions in LC-QqQ for workplace/roadside screening, validates enantioseparation on Lux® Cellulose-2 CSP-HPLC (α=1.45), and benchmarks fluoro-substituent SAR in trace amine-associated receptor (TAAR1) homology models. Forensic casework quantitates microgram metabolites in meconium; contract research organizations profile P450-mediated demethylenation (CYP2D6 selectivity). Toxicology consortia employ as positive controls for novel stimulant alerts.

Bulk powder format dominates 35% analytical reference sector, propelled by gravimetric flexibility versus unit-dosed alternatives.

Ordering, Availability & Fulfillment

Continuous-feed synthesis maintains 500g+ ready stock via WooCommerce 9.4 enterprise (SOC2 Type II), transacting through Stripe Elements v4 / BTC Lightning. Fulfillment dispatches ambient (<30g) or frozen (>30g) via FedEx Clinical Pak® (DOM 24-48h, INT 3-7d) with OFAC screening. Account dashboards furnish COA reprints, retest notifications, and SDS updates; government net-60 with SAM.gov validation.​

Supply chain resilience accommodates peak academic requisition cycles.

Legal & Regulatory Disclaimer

Supply restricted to legitimate laboratory research, expressly excluding human/veterinary administration, therapeutic modalities, diagnostic utilities, or consumptive intents. Transferees acknowledge and assume unqualified liability for all jurisdictional compliance, spanning Controlled Substances Act analogs (21 USC §813), Novel Psychoactive Substances Regulations (EU 2017/2101), and import/export conventions. No indemnification proffered for proscribed diversions; pre-qualification via End-User Statement compulsory. For research use only. Not for human or veterinary use. Not for clinical, diagnostic, or consumptive applications.