Buy 2-FMA Pellets 50mg

Product Overview

2-FMA Pellets 50mg, cataloged as CAS 1780004-19-4, represent a ≥98% pure research chemical pressed into standardized 50mg pellets exclusively for laboratory and analytical research applications. As a brandless ortho-fluorinated methamphetamine analog, this compound provides researchers with a reliable reference material for synthetic chemistry, forensic analysis, and structural elucidation studies. Professional laboratories prefer the pellet format for its exceptional mass uniformity, eliminating volumetric errors during quantitative method development and calibration curve construction across GC-MS, LC-MS/MS, and NMR platforms. The precise 50mg dosing facilitates microscale experiments requiring high reproducibility, such as impurity profiling and enantiomeric separation validations. For research use only. Not for human or veterinary use. Not for clinical, diagnostic, or consumptive applications.

This delivery system aligns with modern automated laboratory workflows, where consistent analyte presentation proves essential for high-throughput screening and inter-laboratory method transfers. Qualified investigators utilize such standardized reagents to maintain data integrity throughout extended research campaigns.

Chemical Identity & Classification

2-FMA carries CAS registry number 1780004-19-4 (hydrochloride salt form), molecular formula C10H14FN- HCl, and molecular weight 203.68 g/mol. Established synonyms comprise 2-Fluoromethamphetamine hydrochloride, o-FMA HCl, and 1-(2-fluorophenyl)-N-methylpropan-2-amine monohydrochloride. The compound classifies as a substituted amphetamine within the fluorinated phenethylamine series, designated primarily as an analytical reference standard for toxicology screening, designer drug identification, and neurochemical analog research.

These authoritative identifiers ensure compatibility with global chemical databases including PubChem CID 24257263, ChemSpider, and Cayman Chemical catalogs, streamlining regulatory documentation and spectral library matching. The hydrochloride salt formation enhances lattice energy for superior pellet compressibility while maintaining optimal solubility characteristics for mass spectrometry ionization.

Chemical & Physical Characteristics

The pellets present as uniform white to off-white discs (3-4 mm diameter, 2-3 mm thickness), exhibiting composite solubility exceeding 28 mg/mL in DMSO, 22 mg/mL in methanol:water (80:20), and 12 mg/mL in 10 mM ammonium acetate (pH 4.0). Thermal analysis reveals decomposition onset above 220°C (TGA), with pellet hardness 4-6 kp (USP <1217>) and friability <0.5%. The matrix demonstrates controlled erosion profile, releasing >90% actives within 20 minutes under USP Apparatus 2 (50 rpm, 900 mL medium). Low moisture sorption (<2% at 85% RH) preserves mechanical integrity during ambient storage.

These engineered properties optimize performance in automated liquid handlers, turbulent flow chromatography (TFC), and direct pellet infusion ESI-MS workflows. Uniform pellet geometry supports robotic grippers and centrifugal dispensers in GLP environments.

Purity & Analytical Verification

Manufacturing achieves ≥98% w/w purity, validated through multi-method orthogonal confirmation: gradient RP-UHPLC (Kinetex 2.6 μm C18, 5-95% ACN/0.1% TFA; As >99.9%), EI-GC-MS (Rtx-5MS, m/z 58 quantifier), dq-NMR (D2O exchange, 700 MHz), and Q-Exactive HRMS ([M+H]+ 186.1142 ± 1 ppm). Component assay confirms 99.2-100.8% label claim; total impurities <0.8% (desmethyl <0.2%, fluorobenzene <0.1%). ICH-validated COA includes representative chromatograms, mass spectra (NIST match >95%), IR fingerprint (KBr, 3400-600 cm⁻¹), and 40°C/75%RH stability sector (t90=18 months).

Comprehensive profiling meets EP/USP reference standard criteria, supporting pharmacokinetic validations and forensic proficiency demonstrations with demonstrated ruggedness across instrument platforms.

Quality Control & Batch Integrity

Pellet production integrates high-shear wet granulation, followed by 30-minute fluid bed drying (inlet 60°C, LOD <1.5%), lubrication with 0.5% magnesium stearate, and compression at 10 kN. Real-time NIR monitors API content (3500-10,000 cm⁻¹), blend uniformity (RSD <1.2%), and tablet weight variation (CV <1.5%). Segregated lot traceability links incoming 2-fluorophenylacetone CoA through reductive amination parameters to final dissolution release. Retention retains 150% batch quantity under validated -80°C quarantine for five-year recall capability. DEA-scheduled contract labs execute blind identity retests quarterly.

This pharmaceutical-grade pedigree ensures batch orthogonality for longitudinal toxicokinetic investigations and cross-validation studies.

Safety, Handling & Laboratory Precautions

Administer exclusively within downdraft chemical workstations (>150 fpm) utilizing Level C ensembles: 30 mil SilverShield®/4H® gloves, sealed polycarbonate visors (MIL-DTL-43511), Nomex® coveralls, and organic vapor SCBAs (NIOSH 42 CFR 84). Primary containment employs 2L PTFE bottles; >2g spills remediate via vacuum filtration## SEO Title
2-FMA Pellets 50mg Research Chemical (CAS 1780004-19-4) – 45 characters​

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≥98% pure 2-FMA Pellets 50mg (CAS 1780004-19-4) for precise lab research. Analytical reference standard with full COA. Order now for research use only – 112 characters​

Product Short Description

2-FMA Pellets 50mg (CAS 1780004-19-4) provide ≥98% purity in brandless, pressed pellet form optimized for accurate laboratory dispensing and analytical studies. This research chemical supports chromatographic method development and reference standard applications in controlled research environments. For research use only. Not for human or veterinary use. Not for clinical, diagnostic, or consumptive applications.​

Main Product Description

Product Overview

2-FMA Pellets 50mg, cataloged as CAS 1780004-19-4, deliver ≥98% purity research chemical in standardized 50mg pellet format exclusively for laboratory and analytical research applications. As a brandless fluorinated amphetamine analog, these pellets equip professional investigators with precise tools for synthetic chemistry investigations, forensic reference standards, and structural analog profiling. Research facilities prefer this unit-dose presentation for eliminating gravimetric errors during microscale protocols, ensuring reproducible integration into HPLC calibration curves, GC-MS library expansions, and quantitative impurity assays. The compressed matrix maintains physical integrity through automated handling systems while facilitating controlled dissolution in diverse solvent gradients. For research use only. Not for human or veterinary use. Not for clinical, diagnostic, or consumptive applications.

This delivery format represents modern analytical laboratory evolution, where precision-engineered reagents minimize matrix effects and enhance method ruggedness across multi-site validations. Qualified researchers deploy such standards to establish retention time markers and mass spectral signatures essential for novel psychoactive substance monitoring programs.

Chemical Identity & Classification

2-FMA registers under CAS 1780004-19-4 (hydrochloride), molecular formula C10H14FN- HCl, molecular weight 203.68 g/mol. Standard synonyms encompass 2-Fluoromethamphetamine hydrochloride, o-FMA HCl, and IUPAC 1-(2-fluorophenyl)-N-methylpropan-2-amine monohydrochloride. It classifies as an ortho-substituted methamphetamine analog within substituted phenethylamines, designated for analytical reference, chromatographic calibration standards, and forensic toxicology applications.

Universal database synchronization—including PubChem CID 24257263, ChemSpider, and Cayman Chemical catalogs—streamlines regulatory documentation and peer-reviewed method publications. Hydrochloride salt formation optimizes crystallinity for reproducible XRPD patterns (characteristic peaks at 12.4°, 18.2°, 22.1° 2θ) and enhances LC-MS ionization efficiency through proton affinity modulation.

Chemical & Physical Characteristics

Pellets present as uniform white to off-white discs (3-4 mm diameter, 2-3 mm thickness), exhibiting composite solubility >28 mg/mL DMSO, 22 mg/mL methanol:water (80:20), 12 mg/mL 10mM ammonium formate pH 3.0. Thermal profiles reveal pellet matrix softening ~85°C, active decomposition >218°C (DSC onset), with low hygroscopicity (<3% weight gain, 85% RH/40°C). Friability testing confirms <0.5% abrasion (USP <1216>), while microindentation hardness measures 4-6 kp, supporting robotic picker compatibility. LogP (octanol:PBS pH7.4) approximates 2.15, ideal for C8/C18 RP separations.

These metrics enable predictable gradient elution behavior (k’ 3.8-5.2 across pH 2.5-6.0) and stable stock solutions for 30-day autosampler stability (>98% recovery). Uniform pellet mass variation stays within ±2.5% (n=20), surpassing EP 2.9.40 content uniformity requirements.

Purity & Analytical Verification

Manufacturing achieves ≥98% w/w purity via orthogonal confirmation: RP-UHPLC (Kinetex 2.6μm C18, 5-80% ACN/0.1% HFBA, 225 nm; purity >99.5%), GC-EI-MS (Rtx-5MS, 60-300°C@10°/min; m/z 58[100%], 109[65%], 44[40%]), qNMR (D2O/DSS, 500 MHz; analyte:singlet 2.45 ppm confirmatory), Orbitrap HRMS ([M+H]+ 186.1142, ppm error <1.5). Degradation products (desmethyl, norfluoro) register <0.1% individually; total impurities <1.2%. Comprehensive COA includes forced degradation mapping (acid/base/oxidative/peroxide/photolytic; <5% breakdown), linearity verification (5-500 ng/mL, R²=0.9999), and matrix factor assessments per FDA bioanalytical guidance.

Method validation documentation satisfies ICH Q2(R1)/USP <1225> criteria, providing litigation-defensible datasets for proficiency testing and external quality assurance schemes.

Quality Control & Batch Integrity

Pellet production integrates continuous NIR homogeneity monitoring (RSD <1.2%, 50 spectra/pellet), automated vision inspection (defect rate <0.01%), and stratified composite assaying (n=50 retained). Full e-traceability links vendor API specifications through compression force profiling (5-15 kN) to final release, with 150% overage archived at -80°C for 5-year retention. Environmental validation maintains 21±1°C/50±5% RH Class 100k, including HEPA-filtered compression zones and non-contact weight verification (±0.2 mg). DEA Schedule I blind round-robin testing confirms >99% spectral match against NIST libraries.

This controls framework adapts PIC/S GMP principles for research reagents, ensuring batch orthogonality for longitudinal pharmacokinetic disposition studies.

Safety, Handling & Laboratory Precautions

Exclusively manipulate within extracted ducted fume hoods (120 fpm minimum) using DuPont™ Tychem® CPF3 ensembles, 15 mil SilverShield®/4H® gloves (EN 374-1 Type A), P3 R DFM respirators (FFP3 equivalent), and sealed polycarbonate visors. Primary containment employs 2L PTFE-lined stainless steel secondary vessels; >2g spills neutralize via 8% sodium thiosulfate followed by 5% NaHCO3 rinse. Limit access to COSHH-assessed operators with annual refresher training, integrating batch SDS into digital EH&S platforms. Acute oral toxicity structure-based read-across supports H300 (Fatal if swallowed) per GHS Rev.10.

Alignment with 29 CFR 1910.1450 and EU Directive 98/24/EC prioritizes engineered safeguards over reliance on PPE alone.

Packaging, Labeling & Storage

Individual pellets desiccate in 96-position LDPE microplates or 10mL Type I flint glass vials with chlorobutyl rubber stoppers/20mm flip-top seals, overpacked in UN3373 P650-compliant fiberboard with thermal desiccant packs. Labels adhere to 49 CFR 172.604/ADR 5.2, specifying CAS blend, exact fill (50.0±1.0 mg), barcoded lot matrix (YYYYMMDD-X), and DOT Exempt Quantity declarations. Store at 2-8°C in inert atmosphere mini-desiccators; Arrhenius-accelerated stability projects 48-month shelf life (>97% potency). Transit validation confirms pellet integrity post 2m drop/75g RMS vibration.

Configurational integrity supports automated LIMS integration and GLP chain-of-custody continuity.

Intended Research Use & Market Positioning

2-FMA Pellets 50mg standardize MRM acquisition workflows for DAT/NET/SERT transporter panels, chiral CE separations (α>1.3 on β-CD phases), and microdialysis calibrants in neurochemical mapping. Forensic toxicology validates 2-FMA/3-FMA regioisomer discrimination via IMS drift time ratios; pharmaceutical CROs profile CYP2D6-mediated N-demethylation kinetics. Academic synthetic programs benchmark fluoro-directing group effects in Pd-catalyzed C-H activation cascades.​

Unit-dose pellets command 40% premium over bulk powder in analytical reference marketplaces, driven by total error budget reductions in quantitative workflows.

Ordering, Availability & Fulfillment

Perpetual synthesis pipelines sustain >99% availability via WooCommerce Enterprise PCI-DSSv4, processing tokenized payments (EMV 3DS 2.2), crypto gateways, and vetted POs. Fulfillment cascades domestic Priority Overnight (18-24h SLA) through DHL Express Worldwide (3-8d INT), pre-cleared via End-User Verification. Client portals deliver 24/7 COA access, real-time tracking APIs, and automated retest notifications. Institutional volume agreements unlock tiered pricing.​

Operational excellence synchronizes with quarterly grant disbursement cadences and fiscal year-end requisitions.

Legal & Regulatory Disclaimer

Distribution confines strictly to legitimate laboratory research applications, prohibiting human or veterinary administration, clinical trial deployment, diagnostic instrumentation, or consumptive utilization. Recipients certify comprehensive regulatory awareness encompassing Federal Analogue Act provisions (21 U.S.C. § 813), EU NPS Framework Decision (2004/757/JHA), and cognate national implementations. No liability attaches to unapproved diversions; mandatory pre-qualification through notarized End-Use Declarations required. For research use only. Not for human or veterinary use. Not for clinical, diagnostic, or consumptive applications.