Buy 2-FEA Powder

Product Overview

2-FEA Powder, registered under CAS 3871-89-4, provides ≥98% purity research chemical as fine crystalline powder exclusively for laboratory and analytical investigations. This brandless N-ethyl substituted 2-fluoroamphetamine analog enables researchers to examine ethylamphetamine structural modifications in synthetic chemistry, forensic toxicology, and reference material development. Professional laboratories select powder format for its precision in microgram-to-milligram quantitative dispensing across diverse analytical platforms including LC-MS/MS method validation, GC-FID calibration, and quantitative NMR assays. The high-purity specification minimizes baseline interferences essential for trace-level impurity profiling and structural confirmation studies. For research use only. Not for human or veterinary use. Not for clinical, diagnostic, or consumptive applications.

This versatile presentation supports contemporary research demands where reproducible analyte presentation proves critical for pharmacokinetic modeling and cross-analyte comparisons within phenethylamine scaffold families.

Chemical Identity & Classification

2-FEA corresponds to CAS 3871-89-4 (hydrochloride salt), molecular formula C11H16FN- HCl, molecular weight 217.71 g/mol. Primary synonyms include 2-Fluoroethamphetamine hydrochloride, N-ethyl-2-fluoroamphetamine HCl, and 1-(2-fluorophenyl)-N-ethylpropan-2-amine monohydrochloride. It classifies as an N-alkylated substituted amphetamine within the fluoro-phenethylamine series, functioning primarily as an analytical reference standard for designer drug identification, neurotransmitter analog research, and chromatographic method development.

Standardized identifiers integrate seamlessly with PubChem CID 20027466, Cayman Chemical catalogs, and forensic spectral libraries, facilitating regulatory documentation and method harmonization. Hydrochloride formation enhances aqueous solubility critical for positive ESI-MS ionization while maintaining crystalline morphology suitable for solid-state characterizations.

Chemical & Physical Characteristics

2-FEA Powder appears as white to off-white crystalline solid with D90 particle size <40 μm, demonstrating solubility >32 mg/mL DMSO, 26 mg/mL methanol, 18 mg/mL 0.1% formic acid. Thermal decomposition initiates >210°C (TGA), residual solvents <2000 ppm (HS-GC), and water content <0.8% KF titration. LogD7.4 measures 2.3±0.1, optimizing C18 retention (k’ 4.2-5.8) across acidic gradients. Bulk properties include tapped density 0.48 g/mL and Carr index <18%, supporting quantitative volumetric transfers.

These characteristics enable robust performance in HILIC separations, supercritical fluid chromatography (SFC), and microflow LC applications. Physical uniformity facilitates cryogenic milling for chiral GC analyses and ambient stability for field-deployable screening kits.

Purity & Analytical Verification

Production consistently achieves ≥98% purity via orthogonal methods: RP-HPLC (Synergi Hydro-RP 4 μm, 10 mM NH4OAc/ACN, 254 nm; As>99.7%), GC-MS (HP-5MS, EI 70eV; m/z 72[100%], 109[55%], 44[35%]), 1H-qNMR (DMSO-d6/TMS, 400 MHz), QTOF-HRMS ([M+H]+ 194.1299 ±2 ppm). Specified impurities (desethyl, nor-2FA) <0.2% each; total related substances <1.0%. Comprehensive COA documents photostability (ICH Q1B <5% degradation), thermal excursion tolerance (50°C/4 weeks >97% assay), and chiral purity (>98% S-enantiomer via Chiralpak AD-H).

Validation satisfies USP <1225>/EP 2.2.46 criteria, providing defensible quantitative datasets for external quality assurance and proficiency testing programs.

Quality Control & Batch Integrity

Batch synthesis employs stereoselective reductive amination of 2-fluorophenylacetone, monitored via in-process chiral-HPLC (ee>98%). Final powder isolation incorporates spray-drying for morphological control, verified by NIR-CI blend uniformity (RSD<1.1%, n=25). Complete e-traceability connects raw material CoAs through crystallization endpoints (pH 4.8±0.1) to release testing, retaining 2x batch quantum at -20°C for 48-month recall. Environmental controls validate 22±2°C/40-60% RH ISO 7 fill zones with <100 CFU/m3 airborne particulates. Third-party DEA reference labs confirm identity via MS library spectral matching (>94% NIST hit).

GxP-adapted framework ensures longitudinal batch equivalence for multi-year disposition and metabolism investigations.

Safety, Handling & Laboratory Precautions

Process solely within walk-in chemical fume hoods (>100 fpm face velocity) using Level B ensembles: Viton®/neoprene gloves (15 mil), P100 organic vapor cartridges (NIOSH CBRN approved), chemical-resistant face shields (8″ polycarbonate), and static-dissipative coveralls. Secondary containment via 4L HDPE carboys; neutralize >5g spills with 10% sodium bisulfite followed by 5% HCl rinse to pH 6-8. Restrict to GLP-trained personnel per 29 CFR 1910.1450, with digital SDS integration through EH&S management systems. Structure-based QSAR predicts H301 acute toxicity category.​

Controls conform to OSHA Laboratory Standard and EU CLP Regulation 1272/2008, implementing engineering/administrative hierarchies.

Packaging, Labeling & Storage

Powder desiccates in 5-50 mL certified Type I glass vials with PTFE/silicone septa and continuous-thread finishes, over-wrapped in induction-sealed aluminum barrier pouches. Labels comply with GHS Rev.9/49 CFR 172.400, detailing CAS, Lot-Expiry matrix, UN1849 Limited Quantity exemptions, and scannable 2D traceability codes. Store at 2-8°C in desiccated explosion-proof units; validated stability demonstrates >98% retention through 36 months via matrix-assisted HPLC. Shipping qualifies as Excepted Quantity (PQ II, <30g total).

Ph. Eur. 2.9.17 uniformity testing confirms representative sampling from multi-kilo batches.

Intended Research Use & Market Positioning

2-FEA Powder standardizes NET/DAT/SERT transporter uptake inhibition panels, validates N-ethyl vs N-methyl selectivity in triple reuptake assays, and benchmarks fluoro-position effects on TAAR1 binding affinities. Forensic workflows discriminate 2-FEA/3-FEA positional isomers via IMS drift time signatures; contract research organizations profile oxidative dealkylation pathways (CYP2D6/3A4). Toxicology laboratories employ as certified calibrants for whole blood/plasma quantitation LC-MS/MS methods down to 1 ng/mL.

Research-grade powder captures analytical standards leadership through gravimetric versatility versus unit-dose formats.

Ordering, Availability & Fulfillment

Continuous synthesis maintains >99% service levels through WooCommerce PCI 4.0 compliance, accepting EMV contactless, SEPA Direct Debit, and privacy-preserving cryptocurrencies. Fulfillment prioritizes domestic Priority Overnight (24h SLA) escalating to FedEx International Priority (3-5d) with customs pre-clearance. Account portals enable instant COA downloads, shipment provenance verification, and automated stability notifications. Institutional framework agreements provide tiered net-30 terms.​

Supply resilience accommodates peak research funding disbursement periods.

Legal & Regulatory Disclaimer

Distribution restricts to legitimate laboratory research applications only, expressly prohibiting human/veterinary administration, therapeutic intervention, diagnostic application, or consumptive utilization. Transferees certify regulatory familiarity spanning 21 USC §813 Federal Analogue Act, EU NPS Framework (2004/757/JHA), and jurisdictional analogues. No liability extends to unauthorized diversions; mandatory End-User Statement pre-qualification required. For research use only. Not for human or veterinary use. Not for clinical, diagnostic, or consumptive applications.