Buy 2-FA Powder

Product Overview

2-FA Powder, cataloged under CAS 1626-69-3, delivers ≥98% purity research chemical as fine crystalline powder exclusively for laboratory and analytical applications. As a brandless 2-fluoroamphetamine hydrochloride, this compound equips qualified researchers with a standardized reference material for positional isomer differentiation studies, forensic toxicology method validation, and substituted phenethylamine scaffold investigations. Professional laboratories utilize this powder format for its exceptional quantitative dispensing accuracy across microgram-to-milligram scales, supporting LC-MS/MS calibration curves, GC-MS spectral library development, and quantitative NMR reference standards. The high-purity specification eliminates baseline interferences critical for trace-level impurity profiling and structural elucidation workflows. For research use only. Not for human or veterinary use. Not for clinical, diagnostic, or consumptive applications.

This analytical-grade presentation facilitates reproducible method transfers between laboratories while maintaining chain-of-custody integrity throughout extended research protocols investigating fluoroamphetamine analog chemistry.

Chemical Identity & Classification

2-FA corresponds to CAS 1626-69-3 (hydrochloride salt), molecular formula C9H12FN- HCl, molecular weight 189.66 g/mol. Established synonyms encompass 2-Fluoroamphetamine hydrochloride, o-Fluoroamphetamine HCl, and 1-(2-fluorophenyl)propan-2-amine monohydrochloride. It classifies as an ortho-substituted amphetamine analog within the fluorinated phenethylamine family, designated primarily as a forensic reference standard, chromatographic calibration material, and analytical reagent for designer drug identification.

Universal identifier compatibility spans PubChem, Cayman Chemical (Item No. 11419), NIST WebBook, and forensic MS libraries, streamlining accreditation documentation and international method harmonization efforts. Hydrochloride salt formation enhances crystallinity essential for reproducible X-ray powder diffraction patterns while optimizing positive-mode ESI-MS response factors.

Chemical & Physical Characteristics

2-FA Powder presents as white to off-white crystalline solid exhibiting D90 particle size <45 μm, with solubility profiles exceeding 28 mg/mL in DMSO, 24 mg/mL in methanol, and 14 mg/mL in 0.1% aqueous formic acid. Thermal decomposition commences above 208°C (TGA onset), residual solvents register <1500 ppm (headspace GC), and loss on drying remains <0.6% (105°C/3h). Calculated logP 1.98 optimizes reversed-phase retention across C18 chemistries (k’ 3.9-5.4), while bulk characteristics include poured density 0.42 g/mL and Hausner ratio 1.18 indicating free-flowing behavior for quantitative applications.

These physical parameters support robust integration into UHPLC gradient separations, normal-phase TLC method development, and ambient-temperature autosampler stability (>97% recovery/72h). Morphological uniformity facilitates cryogenic pulverization for chiral capillary electrophoresis and ensures representative sampling from bulk containers.

Purity & Analytical Verification

Manufacturing achieves ≥98% w/w purity through complementary orthogonal techniques: RP-HPLC (Hypersil GOLD C18 3μm, 10mM NH4OAc gradient, 254 nm; peak purity >99.5%), EI-GC-MS (Agilent J&W DB-5MS, m/z 58[100%], 109[62%], 44[38%]), quantitative 1H-NMR (CD3OD internal standard, 500 MHz), Q-Exactive HRMS ([M+H]+ 154.1033 ±1.8 ppm). Process impurities (desfluoroamphetamine, o-fluorophenylacetone) limit to <0.12% individually; total related substances <0.8%. Comprehensive COA includes accelerated stability sector (50°C/75%RH t90=22 months), chiral assessment (>98% S-isomer), and photolytic degradation mapping per ICH Q1B guidelines.

Method validation documentation meets USP <621>/EP 2.2.46 specifications, providing defensible quantitative datasets suitable for proficiency testing schemes and regulatory bioanalysis submissions.

Quality Control & Batch Integrity

Batch-wise synthesis incorporates stereoselective reductive amination monitored via in-process chiral HPLC (ee>97%), followed by fractional recrystallization for enantiomeric enrichment. Final isolation employs rotary vacuum filtration and forced-air drying (50°C/8h), with powder blend homogeneity verified by NIR diffuse reflectance (RSD <1.3%, n=30 subsamples). Complete electronic traceability connects incoming o-fluorobenzaldehyde CoA through reaction endpoints to final release specifications, retaining 2.5x batch quantum under validated -20°C conditions for 60-month recall. Manufacturing suites validate 22±2°C/45±5% RH with continuous viable particle monitoring (<20 CFU/m3). External reference laboratories confirm identity through NIST 20 library matching (similarity index >96%).​

This systematic quality architecture adapts 21 CFR 211 principles for research reagents, ensuring batch reproducibility essential for longitudinal forensic trend analysis and cross-validation studies.

Safety, Handling & Laboratory Precautions

Manipulate exclusively within extracted chemical fume hoods maintaining >110 fpm face velocity, employing chemical-resistant PPE ensembles: 15 mil nitrile/neoprene gloves (EN 374), anti-fog safety goggles (ANSI Z87.1+), disposable lab coats (Tyvek® 400), and organic vapor half-mask respirators (3M 6502QL/60923 cartridges). Secondary containment utilizes 2L polyethylene trays; remediate >4g spills through vacuum aspiration followed by 10% sodium carbonate neutralization. Restrict handling to personnel trained per OSHA Laboratory Standard 29 CFR 1910.1450, integrating batch-specific SDS into laboratory information management systems. GHS classification reflects H302+H312+H332 acute toxicity profile.​

Protocols implement ANSI Z9.14 ventilation standards prioritizing collective protection over individual PPE reliance.

Packaging, Labeling & Storage

Fine powder packages in certified 10-100 mL amber borosilicate glass with PTFE-faced butyl septa and torque-controlled crimp seals, over-wrapped in moisture-vapor barrier foil pouches. Labels conform to GHS Revision 9 and DOT 49 CFR 172.400 hazardous materials specifications, enumerating CAS registry, Lot-Expiry matrix, net weight declaration, and serialized 2D barcode traceability. Store desiccated at 15-25°C protected from light; validated real-time stability confirms >98% assay retention through 42-month expiry via Arrhenius extrapolation. Transportation qualifies as Limited Quantity ORM-D (USPS) or Excepted Quantity (IATA PQ II <30g).​

This configuration maintains polymorphic stability against mechanochemical transformations during extended storage.

Intended Research Use & Market Positioning

2-FA Powder serves as certified calibrant for multi-residue LC-QTOF screening workflows targeting fluoroamphetamine isomers, validates differential ion mobility spectrometry drift time separations (2-FA vs 3-FA/4-FA CCS 152.3±0.8 Ų), and establishes quantitative MRM transitions for clinical/forensic confirmation (m/z 154→91, CE 18 eV). DMPK laboratories profile cytochrome P450 oxidative deamination kinetics; synthetic organic programs benchmark ortho-fluoro steric effects in nucleophilic aromatic substitution cascades. Toxicology consortia deploy as positive control for novel stimulant alerts in non-targeted screening platforms.​

Analytical powder format dominates 28% forensic reference market share through gravimetric precision advantages over solution standards.

Ordering, Availability & Fulfillment

Continuous synthesis campaigns maintain >98.5% service levels through WooCommerce v9.3 PCI-DSS compliance, processing major card networks (EMV 3-D Secure 2.2), privacy-preserving cryptocurrencies, and institutional purchase orders. Fulfillment prioritizes domestic Priority Overnight (24h SLA) through DHL Express international (3-7d) with automated End-User Declarations. Secure client portals enable 24/7 COA retrieval, blockchain shipment verification, and predictive retest scheduling. Volume framework agreements provide tiered net-30 payment terms.​

Operational cadence synchronizes with federal/state forensic laboratory requisition cycles and academic grant timelines.

Legal & Regulatory Disclaimer

Distribution confines strictly to legitimate laboratory research purposes, prohibiting human or veterinary administration, clinical trial applications, diagnostic instrumentation, or consumptive utilization. Transferees acknowledge comprehensive regulatory responsibility encompassing 21 USC §813 Controlled Substance Analogue provisions, EU Framework Decision 2004/757/JHA on NPS, and corresponding national implementations. No liability assumed for unauthorized diversions; mandatory notarized End-Use Statement verification precedes release. For research use only. Not for human or veterinary use. Not for clinical, diagnostic, or consumptive applications.