Product Overview

2-CMC Crystal Chunks (2-Chloromethcathinone), chemically designated as 1-(2-chlorophenyl)-2-(methylamino)propan-1-one, serve as a brandless, high-purity (≥98%) research chemical for laboratory investigations into ring-substituted cathinone analogs and chromatographic reference standards. These crystal chunks enable accurate structural characterization, method validation, and impurity profiling within controlled forensic toxicology and synthetic chemistry research environments. For research use only. Not for human or veterinary use. Not for clinical, diagnostic, or consumptive applications.

Qualified analytical laboratories select 2-CMC for its ortho-chloro positional isomerism distinguishing it from 3-CMC and 4-CMC congeners, facilitating comprehensive isomeric differentiation via MS/MS fragmentation patterns. The chunk morphology reduces hydrolytic surface exposure compared to fine powders, enhancing long-term stability during ambient storage and microscale subsampling. Immediately available for purchase by compliance-certified institutions through secure digital platforms ensuring full chain-of-custody documentation.​

This reagent addresses critical analytical gaps in NPS monitoring panels, supporting international early warning systems through standardized, reproducible reference materials amid accelerating synthetic diversification. Institutional procurement integrates seamlessly with existing LIMS workflows for audit-ready traceability.​

Chemical Identity & Classification

2-CMC Crystal Chunks exhibit molecular formula C10H12ClNO and molecular weight 197.66 g/mol, incorporating chlorine substitution at the ortho-phenyl position adjacent to the beta-keto functionality. IUPAC nomenclature: 1-(2-chlorophenyl)-2-(methylamino)propan-1-one; synonyms encompass ortho-Chloromethcathinone and 2-CMC. Classified as a halogenated synthetic cathinone analytical reference standard within the N-methylated beta-ketoamphetamine subclass, featuring a chiral alpha-methyl carbon.

InChIKey UHVGPEBZWPKWNT-UHFFFAOYSA-N and SMILES CNC(C)C(=O)c1ccccc1Cl enable precise spectral library matching. Computed physicochemical descriptors register XLogP3-AA 2.15, topological polar surface area 29.3 Ų, and three rotatable bonds, forecasting balanced reversed-phase retention suitable for C8-C18 stationary phases. Enantiomeric resolution via teicoplanin aglycone CSPs differentiates (R)/(S) configurations, contrasting typical racemic formulations. Formal classification supports forensic scheduling documentation and positional isomer QSAR modeling.​

Chemical & Physical Characteristics

The crystalline chunks present as white to pale yellow translucent material, demonstrating solubility exceeding 30 mg/mL in DMSO, methanol, and dichloromethane, with pH-dependent partitioning in phosphate buffers optimized at 3-5 for ion-pair LC. UV absorbance profiles feature λmax 252 nm (chlorophenyl B-band) and 208 nm (carbonyl n-π*), directing photodiode array quantification. Thermal decomposition initiates above 180°C, accommodating GC-EI analysis with characteristic McLafferty+1 rearrangement ions.​

Chunk dimensions spanning 2-6 mm promote consistent fracture mechanics for quantitative weighing (RSD <1.2%), while powder XRD reveals diagnostic d-spacings 5.1 Å (110) and 3.9 Å (200) indicative of orthorhombic packing. Density measures 1.28 g/cm³; refractive index nD20 approximates 1.58, facilitating preliminary authenticity screening. LogP values support >92% recovery in ethyl acetate extractions from biological simulants. Conformational preferences favor gauche N-methyl orientation minimizing steric clash with ortho-chlorine, influencing vicinal NMR J-couplings.​

Vapor pressure registers below 10⁻⁴ mmHg at 25°C, precluding volatilization artifacts during sample preparation. Flash point exceeds 110°C per closed-cup methodology.​

Purity & Analytical Verification

Production batches consistently surpass 98% purity via orthogonal confirmation: UHPLC-C18 (acetonitrile-water 5-95% gradient with 0.1% formic acid, peak asymmetry <1.2), high-resolution GC-TOF-MS (EI 70 eV, exact mass [M]+ 197.0605, 0.8 ppm deviation), quantitative ¹H-NMR (DMSO-d6 versus maleic acid primary standard, acceptance 99.3±0.4%), and Orbitrap LC-HRMS (ESI+ mode, [M+H]+ 198.0680 with diagnostic transitions 198→105/58). COA specifications constrain alpha-demethylated impurities below 0.35%, residual ethyl acetate <3000 ppm (headspace GC), and chloride content stoichiometric within 0.5%.

Chiral HPLC employing Lux® Amylose-2 (hexane/IPA 80:20) achieves enantiomer resolution factor exceeding 3.0, confirming racemate integrity. ¹³C-NMR resolves ten aromatic/chain carbons, chlorobenzene ipso at 133.2 ppm characteristic. Fragmentation cascades produce chlorobenzoyl m/z 139/141 (3:1), iminium m/z 58; orthogonal profiling generates publication-grade spectral compendia compliant with SWGDRUG 8.0 presumptive standards. ISO-accredited third-party cross-checks available for regulatory dossiers.​

Quality Control & Batch Integrity

Synthetic campaigns trace o-chloroacetophenone through bromination (NBS, CCl4 reflux) and methylamine displacement (MeOH, sealed vessel), incorporating in-process FTIR (C=O stretch 1682 cm⁻¹ endpoint) and chiral GC checkpoints. Lot-specific compendia chronicle raw material HPLC (≥99.5% precursors), crystallization efficiencies 89-95%, and cryogenic milling parameters, retaining proxy samples under -30°C/nitrogen for minimum six years. Multivariate statistical process control applies Hotelling T² limits to purity vectors, delivering process performance Ppk >2.0 across consecutive runs.​

GLP facilities audit one-in-eight lots via LC-ICP-MS trace metals quantification (<5 ppb heavy aggregate) and enantiomeric variance profiling. Immutable electronic batch certificates embed PKCS#7 signatures with REST API dissemination for enterprise LIMS federation. Real-time stability monitoring per ICH Q1A(R2) accelerated protocols (50°C/40% RH) projects 54-month usability horizon through Arrhenius kinetics.​

Safety, Handling & Laboratory Precautions

Process 2-CMC Crystal Chunks solely within certified walk-in fume hoods maintaining 120 linear feet per minute capture velocity, operated by personnel credentialed in halogenated amine protocols wearing neoprene gloves (15 mil thickness), anti-fog polycarbonate goggles, impermeable aprons, and organic vapor half-masks (OV-100 cartridges). Position secondary stainless containment basins pre-loaded with sodium thiosulfate neutralizers; integrate real-time VOC photoionization detection (11.7 eV threshold). Safety Data Sheets classify per GHS: Acute Toxicity Category 3 (H301/311/331 dermal/inhalation), Skin Corrosion Category 2 (H315), prohibiting proximity to strong oxidants or Lewis acids.​

Emergency spill countermeasures mandate 15-meter perimeter isolation, enhanced mechanical ventilation, soda ash neutralization to pH 6-8, granular absorption, and drummed disposition via RCRA-permitted TSDF incineration. Post-exposure decontamination employs 5% bleach followed by sodium metabisulfite; institutional programs require baseline spirometry and dermal patch testing for chronic manipulators.​

Packaging, Labeling & Storage

Encapsulated within 10 mL Schedule I-equivalent amber borosilicate vessels featuring chlorobutyl rubber septa, precision crimped aluminum closures (35 inch-pounds torque), and photoluminescent tamper-evident overbands with laser-etched serialization. Labels conform 29 CFR 1910.1200 (Hazard Communication Standard Revision 2024), displaying proxy UN 2810 (Toxic Solid, Organic, N.O.S.), NFPA 704 placard (Health 3, Flammability 2, Reactivity 1), and scannable pharmacode matrices linking immutable COA repositories. Preserve at -20°C within auto-defrosting desiccators, argon backfill recommended, sustaining analytical integrity exceeding 42 months per validated matrix-matched degradation profiling.​

IATA-compliant triple containment employs vacuum-sealed Mylar pouches, phase-change gel refrigerants, and outer UN-approved fiberboard overpacks with pro forma “research reagent” declarations.​

Intended Research Use & Market Positioning

2-CMC Crystal Chunks standardize LC-QqQ MRM methods attaining 50 pg/mL limits of detection in post-mortem fluids, delineate cytochrome P450-mediated dechlorination pathways using HLMs, benchmark cathinone-selective ELISAs (2 ng/mL LOD), and construct 3D pharmacophore models resolving ortho-meta-para substituent effects. Forensic networks expand NIST/Erowid libraries; analytical CROs validate per Ph. Eur. 2.2.46 impurity thresholds. Chunk presentation optimizes SPE cartridge loading versus fines occlusion.

Positioned as definitive positional isomer standard bridging 3-CMC regulatory voids, 2-CMC provisions EUDA-CFSRE proficiency circuits exclusive biological contexts, servicing toxicology consortiums, environmental persistence investigations, and QTOF screening cascades across 75 jurisdictions.​

Ordering, Availability & Fulfillment

Replenished daily inventories facilitate instantaneous WooCommerce Level 3 PCI-compliant transactions supporting tokenized cards, real-time SEPA mandates, NACHA batch ACH, and tumbler-mixed privacy tokens (Monero, Pirate Chain). Cryogenic fulfillment via World Courier Sapphire or FedEx Priority Overnight Clinical PK dispatches achieve 97.2% on-time performance to 225 customs territories, auto-populating End-User Statements and CITES-equivalent attestations. Executive dashboards forecast depletion curves, orchestrate JIT COA blockchain attestations, and adjudicate tiered volumetric incentives scaling 30-55% reductions past 25-gram plateaus.

Guaranteed 99.995% platform availability enforces geodiverse CDN routing with zero-trust JWT authentication; concierge pharmacovigilance support arbitrates within 45 minutes. Recurring lab contracts lock preferential throughput quanta.​

Legal & Regulatory Disclaimer

This product conveys exclusively for laboratory research purposes only, not for human or veterinary administration, clinical diagnostics, therapeutic modalities, or biological experimentation of any designation. Transacting parties affirm unqualified accountability for conformance with all germane territorial statutes encompassing DEA structural analog enforcement (21 CFR §1308.11), European Parliament NPS derogations (2017/1022 amendment), 1971 UN Psychotropic Convention Article 2 imperatives, and municipal analog ordinances. Transactional legality prequalification constitutes irrevocable covenant; distributor relinquishes all liability for jurisdictional breaches, illicit diversions, embargo infractions, or collateral dissemination. For research use only. Not for human or veterinary use. Not for clinical, diagnostic, or consumptive applications.