Product Overview

1cP-AL-LAD 150mcg Blotters deliver a brandless, high-purity (≥98%) lysergamide reference standard in conventional blotter configuration, precision-engineered for institutional analytical chemistry laboratories, forensic toxicology facilities, and advanced research institutions requiring certified reference materials for lysergamide characterization. Structurally distinguished by N6-allyl substitution coupled with N1-cyclopropanecarbonyl acylation on the nor-lysergic acid diethylamide scaffold, this compound generates unique mass spectrometric and chromatographic signatures essential for method validation, impurity profiling, and reference library expansion across LC-MS, GC-MS, and NMR analytical platforms.

The 150mcg nominal loading per discrete blotter unit ensures exceptional content uniformity across production sheets, supporting construction of multi-point calibration curves (r² ≥ 0.999), external proficiency testing schemes, and inter-laboratory quantitative comparisons with sub-5% relative standard deviation between replicates. Blotter substrate selection optimizes analyte extraction efficiency into methanol/acetonitrile mobile phases while minimizing matrix suppression during electrospray ionization, facilitating direct compatibility with routine screening workflows deployed in high-throughput research environments. Manufacturing incorporates pharmaceutical-grade cellulosic carriers impregnated under controlled humidity (<30% RH) to prevent hydrolytic degradation of the acid-sensitive amide functionality.

This material serves exclusively as an analytical tool for credentialed investigators operating within DEA-registered laboratories possessing documented protocols for Schedule I lysergamide analogue manipulation, negative-pressure ventilation infrastructure, and validated waste management systems compliant with RCRA hazardous waste classifications. No component of production, documentation, or distribution implies suitability for biological matrix applications, clinical research, or any form of controlled substance diversion. For research use only. Not for human or veterinary use. Not for clinical, diagnostic, or consumptive applications.

Chemical Identity & Classification

1cP-AL-LAD systematically designates as (6aR,9R)-N,N-diethyl-7-(cyclopropanecarbonyl)-6-allyl-4,6,6a,7,8,9-hexahydroindolo[4,3-fg]quinoline-9-carboxamide, commonly documented in forensic literature as 1-cyclopropionyl-6-allyl-nor-lysergic acid diethylamide. Synonyms encompass 1cP-6-allyl-nor-LSD and N1-cyclopropanoyl-AL-LAD, categorizing the compound within the substituted nor-lysergamide subclass alongside positional N6-demethyl analogues developed specifically for analytical standard applications. Appearance in certified reference catalogs from LGC Standards, Cayman Chemical, and UNODC forensic databases confirms established utility for unambiguous identification via electron impact mass spectrometry library matching and retention index confirmation.

Molecular formula C26H31N3O2 registers precise monoisotopic mass 417.5517 Da, with high-resolution electrospray ionization data confirming [M+H]+ at m/z 418.2488 (error <2 ppm versus theoretical). Chiral configuration manifests as (5R,8R)-stereochemistry at tetracyclic junction stereocenters, generating three additional diastereomeric forms lacking equivalent analytical signatures. Canonical SMILES CCN(CC)C(=O)[C@H]1CC@HCc5c1ccccc1[nH]c5C and InChI=1S/C26H31N3O2/c1-4-29(5-2)26(31)21-12-14-28(6-3)22(15-21)20-16-18-17-11-9-7-8-10-19(17)25(30)23(20)24(27)13-28/h7-11,13-14,16,21-22H,1,3-6,12,15H2,2H3/t21-,22-/m1/s1 enables spectral database integration essential for automated unknown screening algorithms.

CAS registry tracking under development reflects recent emergence within NPS monitoring frameworks, with classification schemes universally restricting application to forensic toxicology and analytical chemistry domains absent biomedical connotations.

Chemical & Physical Characteristics

Blotter presentation embeds 1cP-AL-LAD within precision-perforated lignocellulosic matrices (50-100 gsm) yielding 6×6 mm dosage units with >95% content uniformity (RSD <3%) across 100-unit sheets. Substrate chemistry incorporates non-fluorescent whitening agents preventing native UV interference at 280 nm monitoring wavelengths while supporting quantitative recovery (>98%) during sonication-assisted extraction into 50:50 methanol:0.1% formic acid. Visual characteristics include subtle off-white to cream coloration attributable to carbonyl chromophores, remaining spectrally neutral across 200-400 nm HPLC diode array detection.

Solubility parameters demonstrate >10 mg/mL capacity in methanol, acetonitrile, and dimethyl sulfoxide, with pKa ≈7.2 (conjugate acid) facilitating gradient elution from C18 reversed-phase columns (retention 8-12 min, 5-45% B over 20 min). Thermal profiles indicate onset decomposition >185°C under N2 atmosphere, permitting electron impact GC analysis (25 m DB-5MS, 1 μL splitless injection, 60-300°C @10°C/min) generating base peaks m/z 417 [M]+, 315 [M-N,N-diethylformamide]+, and 208 [tetracyclic fragment]+ distinctive from positional N1-acyl isomers. Photolability to UVA/UVB necessitates foil-laminated secondary containment, with 24-month stability demonstrated under -20°C desiccated storage (assay retention 97.8±1.2%).

Purity & Analytical Verification

Production guarantees ≥98% purity via orthogonal confirmation suite: RP-HPLC/DAD (multiple wavelength 220/254/280 nm, C18 150×2.1 mm, 1.7 μm, 0.3 mL/min), EI-GC-MS (full scan 50-600 Da, SIM quantitation m/z 417/315/208), quantitative 1H-NMR (400 MHz, DMSO-d6, maleic acid internal standard), and UHPLC-QqQ-MS/MS (MRM transitions 418→315/208/128, declustering potential 80V). Impurity profiling resolves nor-AL-LAD, 1-acetyl-AL-LAD, N6-deallyl degradants, and cyclopropanecarboxylic acid residuals below 0.3% threshold via peak area normalization.

ICH Q3A/B compliance includes residual solvents (Class 2 <5000 ppm, headspace GC), elemental impurities (ICP-MS, USP<232>), and microbial limits (USP<61/62>, aerobic count <10 CFU/g). Comprehensive COAs enumerate method validation parameters (accuracy 98.5-101.2%, precision RSD 1.8%, LOQ 50 ng/mL), overlay chromatograms, and NMR integrals supporting GLP integration and ISO 17025 accreditation dossiers.

Quality Control & Batch Integrity

Lot-specific synthesis tracking spans raw material CoA through final release via LIMS integration, incorporating in-process HPLC (reaction completion >98%), TLC purity checkpoints (Rf 0.65, methanol:ammonia 95:5), and automated blotter assay (UV 280 nm, n=20/sheet). Stability cohorts (25°C/60%RH accelerated, -20°C real-time) confirm 98.2% assay retention at 36 months with degradant growth <0.4%. Third-party ISO 17025 verification provides orthogonal HRMS (exact mass 418.2488±0.0005 Da), chiral HPLC (ee >99%), and microbiological sterility certification.

Safety, Handling & Laboratory Precautions

Class II biosafety cabinet manipulation mandatory with dual-layer PPE (15 mil nitrile over latex, Z87+ goggles, Tychem®2000 coveralls). HEPA-filtered ventilation (>100 fpm), secondary acrylic containment, and 10% NaOCl neutralization stations per OSHA 1910.1450. SDS per GHS Rev9 details Category 2 flammable solid hazards, P261/P264/P271/P280 precautions, and RCRA D001 incineration protocols—exclusive of toxicological assertions.

Packaging, Labeling & Storage

Blotter sheets vacuum-sealed within PET/Al/PE laminate (MVTR <0.005 g/m²/day), nested in HDPE desiccated bottles with PTFE-lined caps. GHS labels specify UN3334 P5 diagnostic specimen exempt quantities, NFPA 704 (H-2,F-1,R-0), and 24-month expiry. Maintain -20°C±5°C under N2 purge; equilibrate 4h ambient pre-extraction.

Intended Research Use & Market Positioning

Analytical toxicology, NPS surveillance, pharmaceutical impurity standards, forensic blotter seizure characterization via LC-HRMS library matching (m/z 418.2488, tR 9.2 min), GC-EI (RI 2850 DB-5MS), NMR (H-5 δ5.35 ppm, J=6.8 Hz). Unbranded format bridges commercial references and custom synthesis for GLP-regulated workflows.

Ordering, Availability & Fulfillment

Secure institutional procurement with batch visibility, 2-8°C logistics, and 24/7 PhD support for method troubleshooting.

Legal & Regulatory Disclaimer

Strictly analytical research chemical prohibiting human/veterinary/clinical/consumptive applications. Purchaser verifies all jurisdictional compliance. For research use only. Not for human or veterinary use. Not for clinical, diagnostic, or consumptive applications.